Limited effects of temafloxacin compared with ciprofloxacin on T-lymphocyte function

Riesbeck, Kristian; Forsgren, Arne

doi:10.1128/aac.38.4.879

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…One possible explanation is that these antibiotics may also affect the expression of some key adhesion molecules, such as ICAM-1, VCAM-1, etc., on the endothelial cells and may explain the inhibitory effect on TEM of both neutrophils and monocytes. Although many authors have described the immunomodulatory and anti-inflammatory effects of several quinolones on lymphocyte and monocyte functions (7,11,18,36,37), the present study is the first to analyze this effect on endothelial cells.…”

Section: Discussionmentioning

confidence: 93%

Effects of Fluoroquinolones on the Migration of Human Phagocytes through Chlamydia pneumoniae -Infected and Tumor Necrosis Factor Alpha-Stimulated Endothelial Cells

Uriarte

Molestina

Miller

et al. 2004

Antimicrob Agents Chemother

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The anti-inflammatory activities of three quinolones, levofloxacin, moxifloxacin, and gatifloxacin, were investigated with an in vitro model of transendothelial migration (TEM). Human umbilical vein endothelial cells (HUVEC) were seeded in Transwell inserts, treated with serial dilutions of antibiotics, infected with Chlamydia pneumoniae, or stimulated with tumor necrosis factor alpha (TNF-␣). Neutrophils or monocytes were also preincubated with serial dilutions of each antibiotic. TEM was assessed by light microscopic examination of the underside of the polycarbonate membrane, and levels of interleukin-8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) were measured by enzyme-linked immunosorbent assay. In HUVEC infected with C. pneumoniae or stimulated with TNF-␣, all fluoroquinolones significantly decreased neutrophil and monocyte TEM, compared to antibiotic-free controls. Moxifloxacin and gatifloxacin produced a significant decrease in IL-8 in C. pneumoniae-infected and TNF-␣-stimulated HUVEC; however, moxifloxacin was the only fluoroquinolone that produced a significant decrease in MCP-1 levels under both conditions. Results from this study indicate similarities in the anti-inflammatory activities of these fluoroquinolones, although no statistically significant decrease in chemokine secretion was observed when levofloxacin was used. Mechanisms of neutrophil and monocyte TEM inhibition by fluoroquinolone antibiotics are unknown but may be partially due to inhibition of IL-8 and MCP-1 production, respectively.

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Section: Discussionmentioning

confidence: 93%

Effects of Fluoroquinolones on the Migration of Human Phagocytes through Chlamydia pneumoniae -Infected and Tumor Necrosis Factor Alpha-Stimulated Endothelial Cells

Uriarte

Molestina

Miller

et al. 2004

Antimicrob Agents Chemother

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“…A suppressive effect of therapeutically achievable concentrations of trovafloxacin on the synthesis of IL-1␣ and ␤, IL-6, IL-10, GM-CSF, and TNF-␣ by LPS-stimulated human monocytes has also been reported (177). In addition, various authors have observed that 4-quinolones alter T-and B-lymphocyte functions and delay or suppress the proliferative response of human mononuclear cells (117,119,321,322). Taken together, these data support an immunomodulatory effect of some 4-quinolones, at least in vitro.…”

Section: Lexicon Of Immunomodulatory Antibacterial Agentsmentioning

confidence: 93%

Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or “Immuno-Fairy Tales”?

Labro

2000

Clin Microbiol Rev

100

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SUMMARY Professional phagocytes (polymorphonuclear neutrophils and monocytes/macrophages) are a main component of the immune system. These cells are involved in both host defenses and various pathological settings characterized by excessive inflammation. Accordingly, they are key targets for immunomodulatory drugs, among which antibacterial agents are promising candidates. The basic and historical concepts of immunomodulation will first be briefly reviewed. Phagocyte complexity will then be unravelled (at least in terms of what we know about the origin, subsets, ambivalent roles, functional capacities, and transductional pathways of this cell and how to explore them). The core subject of this review will be the many possible interactions between antibacterial agents and phagocytes, classified according to demonstrated or potential clinical relevance (e.g., neutropenia, intracellular accumulation, and modulation of bacterial virulence). A detailed review of direct in vitro effects will be provided for the various antibacterial drug families, followed by a discussion of the clinical relevance of these effects in two particular settings: immune deficiency and inflammatory diseases. The prophylactic and therapeutic use of immunomodulatory antibiotics will be considered before conclusions are drawn about the emerging (optimistic) vision of future therapeutic prospects to deal with largely unknown new diseases and new pathogens by using new agents, new techniques, and a better understanding of the phagocyte in particular and the immune system in general.

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Section: Benzylpyrimidines (Trimethoprim and Analogs)mentioning

confidence: 99%

Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or "Immuno-Fairy Tales"?

Labro¹

2000

Clinical Microbiology Reviews

151

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Limited effects of temafloxacin compared with ciprofloxacin on T-lymphocyte function

Cited by 11 publications

References 23 publications

Effects of Fluoroquinolones on the Migration of Human Phagocytes through Chlamydia pneumoniae -Infected and Tumor Necrosis Factor Alpha-Stimulated Endothelial Cells

Effects of Fluoroquinolones on the Migration of Human Phagocytes through Chlamydia pneumoniae -Infected and Tumor Necrosis Factor Alpha-Stimulated Endothelial Cells

Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or “Immuno-Fairy Tales”?

Interference of Antibacterial Agents with Phagocyte Functions: Immunomodulation or "Immuno-Fairy Tales"?

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