2014
DOI: 10.1016/j.diagmicrobio.2014.08.012
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Limited diagnostic value of two commercial rapid tests for acute leptospirosis detection in Malaysia

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Cited by 11 publications
(12 citation statements)
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“…Insufficient data was available to provide effective comparison between the RDT and validated MAT results; the study of paired acute and convalescent sera samples would provide more conclusive MAT results and allow for better assessment of the antibody detection accuracy of the Leptorapide RDT. Nevertheless, the present results are consistent with other studies carried out in Southeast Asia [ 21 , 22 ] which have likewise shown that sensitivity and specificity of RDTs for Leptospira infections are often low when compared to PCR.…”
Section: Discussionsupporting
confidence: 93%
“…Insufficient data was available to provide effective comparison between the RDT and validated MAT results; the study of paired acute and convalescent sera samples would provide more conclusive MAT results and allow for better assessment of the antibody detection accuracy of the Leptorapide RDT. Nevertheless, the present results are consistent with other studies carried out in Southeast Asia [ 21 , 22 ] which have likewise shown that sensitivity and specificity of RDTs for Leptospira infections are often low when compared to PCR.…”
Section: Discussionsupporting
confidence: 93%
“…Twelve studies employed a cross-sectional design [ 23 , 24 , 25 , 26 , 29 , 30 , 31 , 35 , 36 , 38 , 39 , 41 ], eight are case-control studies [ 28 , 32 , 33 , 34 , 40 , 42 , 43 , 44 ], and two studies are experimental [ 16 , 37 ]. Evaluations were performed among participants from Laos [ 23 , 38 ], Thailand [ 16 , 24 , 33 , 39 , 42 ], Sri Lanka [ 25 , 31 , 36 ], Malaysia [ 26 , 28 , 32 , 34 ], Slovenia [ 29 ], United States [ 30 , 33 , 39 , 40 ], Palau [ 33 ], India [ 35 , 37 , 39 , 43 , 44 ], Barbados [ 39 ], Kenya [ 39 ], New Zealand [ 39 ], Philippines [ 39 ], Puerto Rico [ 39 ], Suriname [ 39 ], The Netherlands [ 39 , 40 , 41 ], Russia [ 39 ], Seychelles [ 39 ], and Indonesia [ 40 ]. The sample matrix used in the studies for the ICT kits was serum and was collected in the first to second week after the onset of fever.…”
Section: Resultsmentioning
confidence: 99%
“…The results shown that the ELISA has a better level of performance as compared to previously evaluated Leptospirosis rapid test that available in Malaysia [5]. The sensitivity is minimally improved with the addition of interpretation for 'intermediate' as positive.…”
Section: Discussionmentioning
confidence: 91%
“…Although MAT is the gold standard diagnostic tool for leptospirosis the result will take at least two days and this test is only available in specialized diagnostic centre because of certain technical expertise requirement. A reliable and faster screening test should be available to help physician to differentiate leptospirosis from other cause of acute febrile illness [5].…”
Section: Discussionmentioning
confidence: 99%
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