Humans and other group-living animals tend to distribute their social effort heterogeneously; individuals predominantly interact with their closest companions while maintaining weaker social bonds with less familiar group members. By incorporating this heterogeneity into a mathematical model we find that a single parameter, which we refer to as social fluidity, controls the level of social mixing in the population. Large values of social fluidity correspond to gregarious behavior whereas small values signify the existence of persistent bonds between individuals. To investigate how social behavior influences the likelihood of an epidemic outbreak we derive an analytical expression of the relationship between social fluidity and the basic reproductive number of an infectious disease. We compare social behavior across 12 species by applying the model to empirical human and animal social interaction data. For species that form strong social bonds, the model describes frequency-dependent transmission that is highly sensitive to changes in social fluidity. As social fluidity increases, animal-disease systems become increasingly density-dependent. Finally, based on a computational disease spread model on empirical social data, we find that social fluidity is a stronger predictor of disease outcomes than both group size and connectivity. S ocial behavior is fundamental to the survival of many species such as ants, humans, and dolphins. It allows the formation of social groups providing fitness advantages from greater access to resources and better protection from predators [1]. Within these groups structure emerges from the interactions that occur when individuals communicate across space, cooperate in sexual or parental behavior, or clash in territorial or mating conflicts [2]. While many animal societies have been studied independently [3], some questions about the nature of social living can only be answered by comparing social behavior across a range of species [4]. This motivates the question: how can we compare the social behavior of one species to that of another?Social animals typically have limited time and resources to invest in their relationships [5]. To compensate, the social effort of an individual tends to be distributed heterogeneously among the members of their group. Despite the growing evidence for this in human communication [6,7,8], attempts to quantify this aspect of sociality in animal systems are often challenged by unavoidable sampling biases [9]. Furthermore, while heterogeneous interaction frequencies and temporal dynamics such as circadian rhythms and bursty activity patterns have become common in social network models [10], realistic assumptions about how individuals distribute their social effort are rarely incorporated.When social interaction requires shared physical space it can also be a conduit for the transmission of infectious disease [11]. It is generally thought that if transmission occurs * ec975@georgetown.edu through the environment then the risk of epidemic is driven by group si...