Limited alcohol consumption and lower risk of diabetes: can we believe our own eyes?

Mukamal, Kenneth J.; Beulens, Joline W.J.

doi:10.1093/ajcn/nqac258

Cited by 1 publication

(3 citation statements)

References 16 publications

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“…Recently, on October 17, 2022 there was a paper published in The American journal of Clinical Nutrition [12] (which was not cited in Canada's Guidance, probably because of the timing of the publication), where the United Kingdom (UK) Biobank was followed by 312.388 patients without DM2 in the duration of 10.9 years (median), where it was found that with those patients who were consuming alcohol moderately and mostly in the form of wine and, it is very important to emphasize, during the meal, not on an empty stomach, there is a 12% less risk of suffering from DM2 (mostly with the people who consumed more than 100 g and less than 200 g a week, as assessed by a questionnaire) which was one of the final goals of the aborted MACH study [12]. Dr. Keneth Mukmal, the lead researcher of the MACH study, whose 100-million-dollar funding was withdrawn, published in the same journal editorial titled "Limited alcohol consumption and lower risk of diabetes: can we believe our own eyes?"…”

Section: Evidence-based Medicinementioning

confidence: 99%

“…The argument that a decrease of DM2 will decrease its related diseases has not been proven by any study [17]. [2,3,8,12,16,17,21,22]. If framed text is in the center relates to both genders.…”

Section: Evidence-based Medicinementioning

confidence: 99%

“…Figure1. Alcohol effects as estimated by relative risk (RR) and confidence intervals (CI) and diagnostic tools on different diseases derived and compiled from references[2,3,8,12,16,17,21,22]. If framed text is in the center relates to both genders.…”

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confidence: 99%

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Alcohol zero: the end, the beginning of the end, or just the end of the beginning?

Ostojic,

Djajic,

Kovacevic-Preradovic

et al. 2023

Explor Cardiol

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Alcohol drinks, especially wine, have been described since 6,000 B.C. For many years in modern medicine, wine in moderation has been considered healthy for cardiovascular prevention, i.e., recommended by nutrition committees. Some regional guidelines still recommend one to two standard drinks per day. By the very recent (January 2023), World Health Organization and Canadian Guidance on alcohol emphasize that any alcoholic drink is hazardous to the health and the safe amount is zero. The risk starts with every single drop. It was also nicely summarized in the manuscript “Alcohol-dose question and the weakest link in a chemical interplay” (Explor Cardiol. 2023;1:15–25. doi: 10.37349/ec.2023.00003) especially from the standpoint of a researcher in the cardiovascular arena. The newest recommendations are based on observational studies and their meta-analysis, therefore establishing associations, pointing out that alcohol may somewhat prevent cardiovascular diseases and diabetes type 2, but with a significant increase in non-cardiovascular morbidity and mortality, especially cancers. Previous recommendations, therefore, may be obsolete as they were based on studies where abstainers from alcoholic beverages had inherent higher risks. The current controversy with conflicting guidelines for alcoholic beverage consumption in the era of precision medicine may stimulate more fundamental investigations up to genetic ones and find the cause-effect relations. In the era of precision medicine, it may come closer to discovering the causes of cancers and many other diseases, enabling predictions of reactions to alcoholic beverages by each person, not just in the population.

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Section: Evidence-based Medicinementioning

confidence: 99%