Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea

Costa-Ribeiro, Hugo; Ribeiro, Tereza Cristina Medrado; Mattos, Ângela Peixoto de; Valois, Sandra; Neri, Daniela; Almeida, Patricia; Cerqueira, Celina M.; Ramos, E; Young, Rosemary J.; Vanderhoof, Jon A.

doi:10.1097/00005176-200301000-00021

Cited by 104 publications

(62 citation statements)

References 14 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…18 In Brazil, a study including 124 children was carried out to assess the effect of Lactobacillus GG on the reduction of fecal losses in children with severe acute diarrhea associated with dehydration (moderate or severe in over 90% of patients). 19 The mean duration of diarrhea right after the intervention was similar (p = 0.59), 38.3±3.8 and 39.1±4.6 hours, respectively, in the groups that received probiotic and placebo. In addition, fecal losses varied considerably in both groups, with similar medians (p = 0.81), 67.7 and 56.1 mL/kg, respectively, in the probiotic and placebo groups.…”

Section: Probiotics and Diarrheamentioning

confidence: 82%

“…In addition, fecal losses varied considerably in both groups, with similar medians (p = 0.81), 67.7 and 56.1 mL/kg, respectively, in the probiotic and placebo groups. 19 A study conducted in Bangladesh assessed the effect of Lactobacillus paracasei in 230 male infants aged 6 to 24 months and with diarrhea for less than 2 days. The study showed that the use of probiotics was associated with a statistically significant reduction in the following parameters of patients with nonrotavirus diarrhea: cumulative fecal loss, number of bowel movements, intake of oral rehydration solution and proportion of children whose diarrhea resolved on the sixth day of intervention.…”

Section: Probiotics and Diarrheamentioning

confidence: 99%

See 1 more Smart Citation

O papel dos probióticos e prebióticos na prática pediátrica

Morais¹,

Jacob²

2006

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

Objective: To review the effects of probiotics and prebiotics in clinical pediatric practice.Sources: MEDLINE was searched, especially for articles that addressed their practical application, in the form of reviews, clinical trials and meta-analyses. Articles that had already been analyzed by the authors were also included.Summary of the findings: Scientific literature on probiotics and prebiotics has remarkably increased in the last 10 years. Their mechanisms of action have been experimentally investigated. Studies indicate that probiotics can act by competing with pathogens, modifying the intestinal environment by reduction in pH, as a result of fermentation products, interacting and modulating local and systemic inflammatory and immune response, among others. Clinical trials and meta-analyses show that probiotics seem to contribute towards the prevention of acute diarrhea and of antibioticassociated diarrhea, in addition to shortening the duration of acute diarrhea. However, the data are inconsistent and there are no studies confirming their efficacy in terms of cost-benefit ratio. Preliminary studies show that probiotics in early life can reduce the occurrence of atopic dermatitis. The addition of prebiotics to infant formulas is associated with the change in the profile of the intestinal microbiota compared to infants fed milk formulas without prebiotics. Conclusions:Evidence indicates that new studies should be carried out about probiotics, prebiotics and symbiotics. The specific clinical effects that each probiotic or prebiotic may cause must be considered.J Pediatr (Rio J). 2006;82(5 Suppl):S189-97: Prebiotics, probiotics, symbiotics, lactobacillus, bifidobacteria, diarrhea. REVIEW ARTICLE

show abstract

Section: Probiotics and Diarrheamentioning

confidence: 82%

Section: Probiotics and Diarrheamentioning

confidence: 99%

O papel dos probióticos e prebióticos na prática pediátrica

Morais¹,

Jacob²

2006

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

show abstract

“…This probiotic is able to decrease the excretion of rotavirus in the stool [58], helping to reduce the spread of the virus, in turn improving the effectiveness of preventive strategies both in communities and during hospitalization. Yet, definitive conclusions cannot be drawn based on the available results [59][60][61]. The effectiveness of treatment with probiotics is demonstrated in mild-to moderateseverity rotavirus gastroenteritis, while the results obtained in the treatment of rotavirus negative forms and, especially, in bacterial infections are inconclusive [54,61].…”

Section: Infectious Gastroenteritismentioning

confidence: 99%

Probiotics and health: An evidence-based review

Aureli

Capurso

Castellazzi

et al. 2011

Pharmacological Research

232

131

View full text Add to dashboard Cite

a b s t r a c tThe intestinal microbiota is an ecosystem formed by a variety of ecological niches, made of several bacterial species and a very large amount of strains. The microbiota is in close contact with the intestinal mucosa or epithelial interface which is, after the respiratory area, the largest surface of the body, occupying approximately 250-400 m 2 . The physiological activities of the microbiota are manifold and are just being unraveled. Based on the observations of the multiple roles played by the microbiota in health and disease, the notion of modifying it with appropriate formulations, i.e. probiotics, is being tested in several settings.This review summarizes the current knowledge on probiotics and discusses both limitations and acquired evidence to support their use in preventive and therapeutic medicine.

show abstract

“…Favorable effects of probiotics are well documented in children with acute diarrheal infections, especially of viral etiology. These conditions were most frequently treated with Lactobacillus GG, L. plantarum and L. casei Shirota, some strains of bifidobacteria, and Streptococcus thermophilus [123][124][125][126][127]. E. coli Nissle 1917 and another nonpathogenic E. coli strain (O83:K24:H1) prevented diarrhea in sucklings and preterm newborns [56,128].…”

Section: Infectious Enterocolitismentioning

confidence: 99%

Probiotics and prebiotics — renaissance of a therapeutic principle

Frič

2007

Open Medicine

View full text Add to dashboard Cite

AbstractProbiotics are nonpathogenic microorganisms mostly of human origin which, when administered in adequate amounts, confer a health benefit on the host and enable to prevent or improve some diseases. Probiotics may be a natural temporary constituent of the resident intestinal microflora, but their concentration is not sufficient for therapeutic purposes. The microbiota, the intestinal epithelium, and the mucosal immune system constitute the gastrointestinal ecosystem. All three components are essential for complete functional and developmental maturity of the system. The viability of intestinal microflora (including probiotic strains) requires the availability of nutritional substrates (prebiotics), i.e. various types of fiber and oligosaccharides. Prebiotics are cleaved by microbial enzymes to numerous substances (short-chain fatty acids, aminoacids, polyamines, growth factors, vitamins and antioxidants) indispensable for metabolic and functional activities of the intestinal mucosa. The principal probiotics in use include lactobacilli, bifidobacteria, some nonpathogenic strains of Escherichia coli, and Saccharomyces boulardii. These microbiota display favourable effects which qualify them for therapeutic use. For this purpose, probiotics have to fulfill a series of requirements verifying their efficacy and safety. Experimental and clinical studies examine the prerequisites for the administration of probiotics in digestive diseases, allergic and atopic affections, as well as in some extraintestinal conditions. Future goals of probiotic application include genomic analysis, controlled postnatal colonisation of the digestive tract, the use of probiotics as carriers of peroral vaccines, and recombinant probiotics with in-situ production and targeted application of therapeutic molecules.

show abstract

Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea

Cited by 104 publications

References 14 publications

O papel dos probióticos e prebióticos na prática pediátrica

O papel dos probióticos e prebióticos na prática pediátrica

Probiotics and health: An evidence-based review

Probiotics and prebiotics — renaissance of a therapeutic principle

Contact Info

Product

Resources

About