Limitations of fluorocarbons in reducing myocardial infarct size

Menasché, Philippe; Escorsin, Marcio; Birkui, P; Lavergne, A; Fauchet, M; Commin, P.; Lorente, P; Geyer, Robert P.; Piwnica, A

doi:10.1016/0002-9149(85)90165-1

Cited by 12 publications

(2 citation statements)

References 20 publications

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“…It has now become clear [33,34] that, if FDA is used in the treatment of acute myocardial ischaemia, a certain length of time is necessary before it exerts a beneficial effect. In the present study, occlusion of the terminal LAD was performed within about 30 min of the completion of haemodilution with FDA.…”

Section: Discussionmentioning

confidence: 99%

Protection Against Myocardial Ischaemia by Prior Haemodilution With Fluorocarbon Emulsions

Faithfull¹,

Fennema²,

Erdmann³

1988

British Journal of Anaesthesia

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The possible prophylactic effects of Fluosol-DA 20% (FDA) haemodilution against myocardial hypoxia were studied in two groups of anaesthetized immature pigs. Precalibrated 200-micron diameter oxygen microelectrodes were inserted to the myocardium of the left ventricle. One group of animals was haemodiluted with FDA and both groups received 100% oxygen (plus halothane). The lower one-third of the left anterior descending coronary artery was occluded; this caused no significant cardiovascular changes. Analysis from the microelectrodes in the most hypoxic areas of the myocardium revealed significant decreases in myocardial oxygen tension (PmO2) in the control group 15 min after occlusion in the FDA-diluted group. Analysis of other electrodes suggested greater hyperaemic compensatory response in ischaemic border areas in the FDA-treated group.

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Section: Discussionmentioning

confidence: 99%

Protection Against Myocardial Ischaemia by Prior Haemodilution With Fluorocarbon Emulsions

Faithfull¹,

Fennema²,

Erdmann³

1988

British Journal of Anaesthesia

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“…105 'Reperfusion injury' is thought to be a phenomenon during which reperfusion following a period of ischaemia of an area of tissue is associated with the conversion of reversible cellular injury into irreversible damage. 106,107 Characteristically, blood flow to the reperfused region shows a progressive decrease in the early period following _ initiation of reperfusion, the so-called 'no reflow' phenomenon.…”

Section: Myocardial Infarction and Reperfusion Injurymentioning

confidence: 99%

Fluorocarbon emulsions

Marchbank

1995

Perfusion

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Perfluorocarbon emulsions have been the topic of intense investigation for many years and presently there are still no absolute indications for their use in clinical practice. The relatively disappointing results of the early clinical studies, as a consequence of using low concentrations of a relatively underdeveloped emulsion, have been responsible for a largely negative impression and it is now essential that the newer second generation emulsions should be judged individually with regard to their efficacy and toxicity under different circumstances. Technological advancement in the fields of chemistry and detergent/emulsifier research will continue and new formulations are being developed which which will require to be tested in models in the laboratory. In the future, this class of drugs will continue to be the topic of intense investigation and their mechanisms of action, which are undoubtedly more complex than the simple carriage of dissolved gases in solution, will be clarified. However, whether fluorocarbon emulsions will ever be used as a 'blood substitute' as was originally anticipated is doubtful.

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Perfluorochemical Oxygen Carriers and Ischaemic Tissues

Lowe

1990

Advances in Experimental Medicine and Biology

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Limitations of fluorocarbons in reducing myocardial infarct size

Cited by 12 publications

References 20 publications

Protection Against Myocardial Ischaemia by Prior Haemodilution With Fluorocarbon Emulsions

Protection Against Myocardial Ischaemia by Prior Haemodilution With Fluorocarbon Emulsions

Fluorocarbon emulsions

Perfluorochemical Oxygen Carriers and Ischaemic Tissues

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