Limitations of Detecting Small Solid Lung Nodules by Using Digital                    Chest Tomosynthesis

Lee, Kyung Soo; Chung, Myung Jin

doi:10.1148/radiol.2018180144

Cited by 2 publications

(2 citation statements)

References 12 publications

(13 reference statements)

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“…In this situation, DTS would be superior as nodule detection is improved compared to CXR (13), although not on par with CT (14–17). The question has been raised whether DTS could be an alternative to CT regarding surveillance of indeterminate nodules with low risk of malignancy (14,18). Söderman et al.…”

Section: Introductionmentioning

confidence: 99%

“…In this situation, DTS would be superior as nodule detection is improved compared to CXR (13), although not on par with CT (14)(15)(16)(17). The question has been raised whether DTS could be an alternative to CT regarding surveillance of indeterminate nodules with low risk of malignancy (14,18). S€ oderman et al (19) investigated nodule growth on simulated nodules in DTS, and reported that the modality could be applicable, but nodule size, position, and dose level affected the precision of the measurements.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surveillance of small, solid pulmonary nodules at digital chest tomosynthesis: data from a cohort of the pilot Swedish CArdioPulmonary bioImage Study (SCAPIS)

et al. 2020

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Background Digital tomosynthesis (DTS) might be a low-dose/low-cost alternative to computed tomography (CT). Purpose To investigate DTS relative to CT for surveillance of incidental, solid pulmonary nodules. Material and Methods Recruited from a population study, 106 participants with indeterminate solid pulmonary nodules on CT underwent surveillance with concurrently performed CT and DTS. Nodule size on DTS was assessed by manual diameter measurements and semi-automatic nodule segmentations were independently performed on CT. Measurement agreement was analyzed according to Bland–Altman with 95% limits of agreement (LoA). Detection of nodule volume change > 25% by DTS in comparison to CT was evaluated with receiver operating characteristics (ROC). Results A total of 81 nodules (76%) were assessed as measurable on DTS by two independent observers. Inter- and intra-observer LoA regarding change in average diameter were ± 2 mm. Calculation of relative volume change on DTS resulted in wide inter- and intra-observer LoA in the order of ± 100% and ± 50%. Comparing relative volume change between DTS and CT resulted in LoA of –58% to 67%. The area under the ROC curve regarding the ability of DTS to detect volumetric changes > 25% on CT was 0.58 (95% confidence interval [CI] = 0.40–0.76) and 0.50 (95% CI = 0.35–0.66) for the two observers. Conclusion The results of the present study show that measurement variability limits the agreement between DTS and CT regarding nodule size change for small solid nodules.

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