Limitations of Current Machine-Learning Models in Predicting Enzymatic Functions for Uncharacterized Proteins
Valérie de Crécy-Lagard,
Raquel Dias,
Iddo Friedberg
et al.
Abstract:Thirty to seventy percent of proteins in any given genome have no assigned function and have been labeled as the protein “unknownme”. This large knowledge gap prevents the biological community from fully leveraging the plethora of genomic data that is now available. Machine-learning approaches are showing some promise in propagating functional knowledge from experimentally characterized proteins to the correct set of isofunctional orthologs. However, they largely fail to predict enzymatic functions unseen in t… Show more
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