Limitations in the use of color indicators in gastric analysis

In Situ Effects of Antacids in Duodenal Ulcer

“…After filtration the free and the total acidity of each specimen were estimated, with Töpfer's reagent and phenolphthalein as the respective color indicators.3 For each duodenal specimen, in addition, there was determined what was called the excess neutralizing ability.4 This is expressed as the amount of tenth-normal hydro¬ chloric acid necessary to lower the pa to the point at which Töpfer's reagent indicated a positive reaction for free acid. 3 The patients were divided into two groups. One patient served as a subject in both groups, making a total of 9 patients in each.…”

New Operation for Peptic Ulcer

“…Perhaps the neutralization of gastric contents by duodenal juices is less adequate in these people than Mr. Aylett hores, and this would be suggested by the work of Berk et al (1942 McCann modification of the Schmilinsky procedure which was introduced in 1918 in an attempt to neutralize the gastric acidity by total intragastric regurgitation of the duodenal secretions. That it fails to do this adequately has been shown by the high incidence of gastro-jejunal ulceration which has followed this type of operation both in experimental animals and in human patients.…”

New Operation for Peptic Ulcer

“…Perhaps the neutralization of gastric contents by duodenal juices is less adequate in these people than Mr. Aylett hores, and this would be suggested by the work of Berk et al (1942). One of Paterson's patients had a jejunal fistula well distal to a gastroenterostomy stoma, where complete mixing might have been expected, yet it discharged fluid containing 0.072% free HC1 (20 milli-equivalents per litre).…”