Limitations in predicting radiation-induced pharmaceutical instability during long-duration spaceflight

Blue, Rebecca S.; Chancellor, Jeffery C.; Antonsen, Erik L.; Bayuse, Tina; Daniels, Vernie; Wotring, Virginia E.

doi:10.1038/s41526-019-0076-1

Cited by 41 publications

(46 citation statements)

References 41 publications

(103 reference statements)

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“…However, for CsPbBr 3 ‐ and CH 3 NH 3 PbBr 3 ‐based devices, neither ON nor OFF state could be maintained after 60 Co radiation. (Figure S14, Supporting Information) This radiation proof of Cs 2 AgBiBr 6 is even better than conventional flash memory techniques (bearable dosage: 10 5 rad) and is an attractive candidate for aerospace and nuclear environments, where irradiation‐immune nonvolatile data storage or high‐speed recording is required …”

Section: Resultsmentioning

confidence: 99%

Environmentally Robust Memristor Enabled by Lead‐Free Double Perovskite for High‐Performance Information Storage

Cheng

Qian

Wang

et al. 2019

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130

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Memristors are emerging as a rising star of new computing and information storage techniques. However, the practical applications are severely challenged by their instability toward harsh conditions, including high moisture, high temperatures, fire, ionizing irradiation, and mechanical bending. In this work, for the first time, lead‐free double perovskite Cs2AgBiBr6 is utilized for environmentally robust memristors, enabling highly efficient information storage. The memory performance of the typical indium‐tin‐oxide/Cs2AgBiBr6/Au sandwich‐like memristors is retained after 1000 switching cycles, 105 s of reading, and 104 times of mechanical bending, comparable to other halide perovskite memristors. Most importantly, the memristive behavior remains robust in harsh environments, including humidity up to 80%, temperatures as high as 453 K, an alcohol burner flame for 10 s, and 60Co γ‐ray irradiation for a dosage of 5 × 105 rad (SI), which is not achieved by any other memristors and commercial flash memory techniques. The realization of an environmentally robust memristor from Cs2AgBiBr6 with a high memory performance will inspire further development of robust electronics using lead‐free double perovskites.

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Section: Resultsmentioning

confidence: 99%

Environmentally Robust Memristor Enabled by Lead‐Free Double Perovskite for High‐Performance Information Storage

Cheng

Qian

Wang

et al. 2019

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130

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“…This results in the densely ionizing core, the path of charged particles, and track generated by ejected electrons. The particles with more charge have the greater ability to ionize the exposed material (Blue et al 2019b).…”

Section: Effect Of Radiations On Pharmaceutical Stabilitymentioning

confidence: 99%

“…The activity of free radicals also varies with changes in the radiation dose-rate. Many pharmaceuticals have shown their stability at higher dose-rates because of higher oxygen consumption leading reduced oxygen radicals to cause damage (Blue et al 2019b;Kempner 2001Kempner , 2011.…”

Section: Effect Of Radiations On Pharmaceutical Stabilitymentioning

confidence: 99%

“…The alteration of radiation exposure dose and dose rate can produce different effect than anticipated from radiosterilization. Hence, the effect of space radiation on physicochemical stability cannot be predicted from the data obtained from radiosterilization (Blue et al 2019b).…”

Section: Challenges To Perform Accelerated Stability Studies For Spacmentioning

confidence: 99%

“…But, due to vast distance from the Earth, there will be no possibility to resupply the medicines or emergency return of the crew during long duration space missions beyond LEO. A study of monitoring use of pharmaceuticals by spaceflight crewmembers during their 5-6 months in ISS showed that an average of 453 medicines were used per crewmember during their space missions, which means about four medicines were consumed per crewmember per week (Blue et al 2019a). Prolonged exposure to harsh space environmental conditions will exacerbate the conditions even more.…”

Section: Introductionmentioning

confidence: 99%

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Physicochemical Stability of Space Medicines

Mehta

Bhayani

2020

Handbook of Space Pharmaceuticals

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Astronauts' health and wellness maintenance in a unique, isolated, and extreme environment of space is a primary goal for a successful space mission. Safe, efficacious, and stable medications are essential to achieve this goal. The unique space environmental factors including microgravity, vibration, vacuum, varying temperature/humidity, and excessive radiation can alter drug stability during spaceflights. Stability of medicines used for space exploration missions cannot

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Nanotechnology enabled radioprotectants to reduce space radiation‐induced reactive oxidative species

Babu

Pawar

Mittal

et al. 2023

WIREs Nanomed Nanobiotechnol

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Interest in space exploration has seen substantial growth following recent launch and operation of modern space technologies. In particular, the possibility of travel beyond low earth orbit is seeing sustained support. However, future deep space travel requires addressing health concerns for crews under continuous, longer‐term exposure to adverse environmental conditions. Among these challenges, radiation‐induced health issues are a major concern. Their potential to induce chronic illness is further potentiated by the microgravity environment. While investigations into the physiological effects of space radiation are still under investigation, studies on model ionizing radiation conditions, in earth and micro‐gravity conditions, can provide needed insight into relevant processes. Substantial formation of high, sustained reactive oxygen species (ROS) evolution during radiation exposure is a clear threat to physiological health of space travelers, producing indirect damage to various cell structures and requiring therapeutic address. Radioprotection toward the skeletal system components is essential to astronaut health, due to the high radio‐absorption cross‐section of bone mineral and local hematopoiesis. Nanotechnology can potentially function as radioprotectant and radiomitigating agents toward ROS and direct radiation damage. Nanoparticle compositions such as gold, silver, platinum, carbon‐based materials, silica, transition metal dichalcogenides, and ceria have all shown potential as viable radioprotectants to mitigate space radiation effects with nanoceria further showing the ability to protect genetic material from oxidative damage in several studies. As research into space radiation‐induced health problems develops, this review intends to provide insights into the nanomaterial design to ameliorate pathological effects from ionizing radiation exposure.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Nanotechnology Approaches to Biology > Cells at the Nanoscale Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Limitations in predicting radiation-induced pharmaceutical instability during long-duration spaceflight

Cited by 41 publications

References 41 publications

Environmentally Robust Memristor Enabled by Lead‐Free Double Perovskite for High‐Performance Information Storage

Environmentally Robust Memristor Enabled by Lead‐Free Double Perovskite for High‐Performance Information Storage

Physicochemical Stability of Space Medicines

Nanotechnology enabled radioprotectants to reduce space radiation‐induced reactive oxidative species

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