Limitation of biocompatibility of hydrated nanocrystalline hydroxyapatite

Minaychev, Vladislav V.; Teleshev, A. T.; Gorshenev, V. N.; Yakovleva, M. A.; Fomichev, V.A.; Pankratov, A. S.; Menshikh, Ksenia A.; Фадеев, Р. С.; Фадеева, И. С.; Сенотов, А. С.; Kobyakova, M. I.; Yurasova, Yu B.; Акатов, В. С.

doi:10.1088/1757-899x/347/1/012045

Cited by 4 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HA exhibits a proper pore size for the growth of bone cells and has sufficient mechanical strength for bone engineering. [ 150 ] A suitable pore size can be achieved using sintering. [ 151 ] Figure 5B shows a HA scaffold achieved by sintering for bone tissue engineering applications.…”

Section: Materials For Hierarchical Tissue Fabricationmentioning

confidence: 99%

Recent Advances in Regenerative Tissue Fabrication: Tools, Materials, and Microenvironment in Hierarchical Aspects

Ratri

Brilian

Setiawati

et al. 2021

Advanced NanoBiomed Research

View full text Add to dashboard Cite

As part of regenerative medicine, artificial, hierarchical tissue engineering is a favorable approach to satisfy the needs of patients for new tissues and organs to replace those with defects caused by age, disease, or trauma or to correct congenital disabilities. However, the application of tissue engineering faces critical issues, such as the biocompatibility of the fabricated tissues and organs, the scaffolding, the complex biomechanical processes within cells, and the regulation of cell biology. Although fabrication strategies, including the traditional bioprinting, photolithography, and organ‐on‐a‐chip methods, as well as combinations of fabrication processes, face many challenges, they are methods that can be used in hierarchical tissue engineering. The strategic approach to synthetic, hierarchical tissue engineering is to use a combination of several technologies incorporating material science, cell biology, additive manufacturing (AM), on‐a‐chip strategies, and biomechanics. Herein, in a review, the current materials and biofabrication strategies of various artificial hierarchical tissues are discussed based on the level of tissue complexity from nano to macrosize and the adaptive interactions between cells and the scaffolding surrounding the incorporated cells.

show abstract

Section: Materials For Hierarchical Tissue Fabricationmentioning

confidence: 99%

Recent Advances in Regenerative Tissue Fabrication: Tools, Materials, and Microenvironment in Hierarchical Aspects

Ratri

Brilian

Setiawati

et al. 2021

Advanced NanoBiomed Research

View full text Add to dashboard Cite

show abstract

Recent Advances in Regenerative Tissue Fabrication: Tools, Materials, and Microenvironment in Hierarchical Aspects

Ratri

Brilian

Setiawati

et al. 2021

Advanced NanoBiomed Research

View full text Add to dashboard Cite

The need for artificial organs and implants to repair and/or replace damaged organs and to correct congenital disabilities of patients is increasing. [1][2][3] If fabricated human-like organs or tissues are to be effective and to function optimally, they have to follow the hierarchical structure, which is a prerequisite to mimic the complex functions of the organs and tissues found in nature. [4] The hierarchical structures of tissue are the nature of living organisms, and the sizes of such structures range from nanometers to micrometers; furthermore, the definitive geometries of artificial organs and tissues give them many advantages, such as strength and biological interactions among subhierarchy levels. [5,6] Interactions between cells and of cells with the matrix surrounding them happen freely and on all sides in the hierarchical construct system. [7] Because the structures and functions of that construct system are essential, human-like artificial organs and tissues fabricated and used for regenerative medicine must mimic that hierarchical structure.The final goal of tissue engineering is to create artificial tissue with the ability to perform biological functions. Nonetheless, materials are a critical part of successful tissue engineering for regenerative medicine. The materials' properties, such as size, stiffness, biocompatibility, and biodegradability, have to be considered during material selection for tissue engineering. Scaffolds have been described as an essential component underlying the successful formation of functional artificial tissues. [8,9] Therefore, with a proper scaffold material, an adequate microenvironment for cell proliferation, cell adhesion, and cell-cell interactions can be achieved. [10] Moreover, a suitable combination of scaffold materials and cells defines the functionality of the hierarchical tissue complex. The embodiment of cells during the fabrication process for cell-laden scaffolds and the incorporation of live cells into the fabricated scaffolds are integral parts of the organization of functionalized artificial tissues. For tissue regeneration, a scaffold, as the framework in tissue engineering, has to provide the features that can induce cellular and biophysical responses through the chemical compositions, elasticity, geometry, and ligand spacing of the biomaterials to modulate the behavior of cells. [11] The signaling cues from a synthetic polymer can be increased by protein incorporation into and addition of

show abstract

Aggregation of Nanosized Hydroxyapatite Particles and Inhibition of Cell Adhesion on this Bio-Active Material as Key Factors that Limit its Biointegration

et al. 2019

View full text Add to dashboard Cite

Limitation of biocompatibility of hydrated nanocrystalline hydroxyapatite

Cited by 4 publications

References 9 publications

Recent Advances in Regenerative Tissue Fabrication: Tools, Materials, and Microenvironment in Hierarchical Aspects

Recent Advances in Regenerative Tissue Fabrication: Tools, Materials, and Microenvironment in Hierarchical Aspects

Recent Advances in Regenerative Tissue Fabrication: Tools, Materials, and Microenvironment in Hierarchical Aspects

Aggregation of Nanosized Hydroxyapatite Particles and Inhibition of Cell Adhesion on this Bio-Active Material as Key Factors that Limit its Biointegration

Contact Info

Product

Resources

About