Limethason reduces airway inflammation in a murine model of ovalbumin-induced chronic asthma without causing side effects

Abstract

Airway inflammation is the major pathological feature of asthma. Thus, the current therapeutic strategy for asthma is to control inflammation. Limethason, an anti-inflammation drug, is widely used in rheumatoid arthritis treatment. The aim of the present study was to detect the anti-inflammatory effect and side effects of limethason on airways that were sensitized with ovalbumin in a murine model of chronic asthma. In the present study, BALB/c mice were sensitized with ovalbumin. Airway hyperresponsiveness was estimated, and hematoxylin and eosin staining, Periodic acid-Schiff staining and bronchoalveolar lavage were used to detect the effect on chronic asthma. Limethason effectively reduced airway hyperresponsiveness, and inhibited inflammatory cell infiltration and mucus secretion. Bronchoalveolar lavage fluid analysis revealed that limethason suppressed levels of airway eosinophils. In the period of treatment, limethason exhibited no influence on morphology of the femoral head, bone mineral content or bone mineral density, which were detected by histological studies and dual-energy X-ray absorptiometry. The index of liver, spleen, kidney, gastrocnemius and brown adipose tissue also demonstrated that limethason had no adverse effects on organs and tissues. The present study revealed that limethason could effectively reduce inflammation in an asthma mouse model without side effects. Therefore, limethason may have therapeutic potential for treating chronic asthma clinically.

Pistacia weinmannifolia root exerts a protective role in ovalbumin‑induced lung inflammation in a mouse allergic asthma model

“…In recent years, the approaches to improve the side effects of medicine have focused on research into allergic asthma (14) and natural herbal extracts are attracting increased attention due to their prominent biological activities and minimal side effects (15). Pistacia weinmannifolia (PW) is used as a herbal medicine in China (16,17) and its major metabolites possess biological activities, such as inhibitory activities against histamine release (16,18,19).…”

Pre-incisional infiltration with ropivacaine plus dexamethasone palmitate emulsion for postoperative pain in patients undergoing craniotomy: study protocol for a prospective, randomized controlled trial

“…D-PAL emulsion, dexamethasone palmitate incorporated into lipid microspheres, has a stronger anti-inflammatory activity, as well as a longer duration of action and fewer side effects than free dexamethasone. The clinical utility of D-PAL emulsion has been reported to treat inflammatory diseases or pain diseases by intravenous administration or local infiltration [ 24 , 25 , 28 , 29 , 37 ]. In this study, we intend to choose the concentration of about 0.027% D-PAL (equivalent to 0.017% dexamethasone) for scalp infiltration, which seems to be the lowest possible concentration of dexamethasone for local use according to previous literatures [ 6 , 37 – 39 ]; thus, it should be considered safe and help reduce the potential risks of local glucocorticoid, such as delayed wound healing and wound infection.…”

Viwithan: A Standardized Ashwagandha Extract Ameliorates Ovalbumininduced Airway-Inflammation and Oxidative Stress in Mouse Model

“…Medicinal plants provide an extensive resource in the search for effective medical treatments with a low risk of adverse effects. Recently, herbal preparations have drawn greater attention for treating respiratory diseases, including airway inflammation, asthma, cystic fibrosis, and chronic bronchitis [8,9]. Withania somnifera (Solanaceae) commonly known as Ashwagandha, Indian ginseng, is an important medicinal plant used long since in indigenous system of medicine including Ayurveda.…”