Limbic lesions and control of the internal and external environment

McGowan, Brenda K.; Hankins, Walter G.; García, John

doi:10.1016/s0091-6773(72)80176-7

Cited by 186 publications

(60 citation statements)

References 21 publications

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“…Scalia & Winans, 1975) may further clarify the neuroanatomical substrates of baitshyness phenomena . Further studies of the amygdala are of additional importance since it is the only structure studied to date which has been implicated in the disruption of both baitshyness acquisition (Elkins, 1970;Kemble & Nagle, 1973;McGowan, Hankins, & Garcia, 1972;Nachman & Ashe, 1974;Rolls & Rolls, 1973) and retention (Nachman & Ashe, 1974). Memory of preoperatively conditioned flavor aversions is not attenuated by lesions of area postrema (Branca, Campbell, & Margules, 1972), the lateral hypothalamus (Schwartz & Teitelbaum, 1974), or ventromedial hypothalamus (Gold & Proulx, 1972).…”

Section: Resultsmentioning

confidence: 99%

Baitshyness retention in rats with olfactory-bulb ablations

Hobbs¹,

Elkins

1976

Psychobiology

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Section: Resultsmentioning

confidence: 99%

Baitshyness retention in rats with olfactory-bulb ablations

Hobbs¹,

Elkins

1976

Psychobiology

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“…Amygdaloid damage has been shown to interfere with response suppression [25], to prevent the formation of induced taste aversion [16,21,24], to attenuate emotional and/or emotional reactions in a number of situations [8,11,15], to eliminate self-punitive behavior [27], to produce significant learning deficits for passive avoidance conditioning [34] and to induce an increase in sniffing, rearing and exploration [6,37].…”

Section: Discussionmentioning

confidence: 99%

Amygdaloid lesions block the effect of neuropeptides (vasopressin, ACTH4–10) on avoidance behavior

Greidanus

Croiset

Bakker

et al. 1979

Physiology & Behavior

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VAN WlMERSMA GREIDANUS, T. B., G. CROISET, E. BAKKER AND H. BOUMAN. Amygdaloid lesions block the effect of neuropeptides (vasopressin, ACTH4_m) on avoidance behavior. PHYSIOL. BEHAV. 22(2) 291-295, 1979.-Lesions in the amygdaloid complex result in an increased activity of rats in open field behavior in that generally more exploration and rearing is observed as compared with sham-operated animals. No effect of the lesion was observed on acquisition and extinction of an active avoidance response, but the amygdala lesions block the inhibitory effect of the neuropeptides vasopressin and ACTH4_~,, on extinction of a conditioned avoidance response. Searching for the CNS sites of action of these neuropeptides in relation to avoidance behavior several brain areas appear to be involved in their inhibitory effects on extinction of an active avoidance response. Implantation studies point to the posterior thalamic area including the parafascicular nuclei as a site of action of ACTH [43] as well as vasopressin [47]. Lesion studies however indicated that this parafascicular area is less essential for vasopressin in relation to its inhibitory effect on avoidance extinction than for ACTH4_., [48]. Subsequent experiments in which additional limbic structures were destroyed such as the rostral septal area [42,49] and the dorsal hippocampal complex [44] revealed that these structures are important for the behavioral effects of vasopressin and ACTH4-1o. From these data it has been suggested that the limbic system needs to be intact in order to allow the neuropeptides vasopressin and ACTH4-10 to display their inhibitory action on active avoidance extinction.Since the amygdaloid complex is an essential part of the limbic system the present study was performed in which the effects of the behaviorally active vasopressin analogue desglycinamide-lysine-8-vasopressin (DG-LVP) [40] and of ACTH4_,, on extinction of an active avoidance response were studied in animals with lesions in the amygdala nuclei. In addition the effect of the amygdaloid lesion itself was studied on exploratory behavior. METHOD AnimalsMale rats of an inbred Wistar strain weighing 130-150 g were used for the experiments. Stereotaxic lesions were made bilaterally in the amygdaloid complex using radiofrequency lesioning. The procedure in the sham-operated rats was identical to that in the amygdaloid lesioned animals except for the current. In the lesioned rats bilateral electrolytic lesions were placed in the baso-lateral amygdala by passing a 2 mA anodal current through the uninsulated 0.5 mm tip of a stainless steel electrode for 40 sec. A rectal cathode completed the circuit. With the incisor bar set 5 mm above the interaural plane and using bregma at the zero point, the following coordinates were employed: posterior -1.0 ram, lateral 4.7 mm and ventral -8.5 mm. ProcedureAfter recovery from the operation, which usually took

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“…This is indicated by the fact that the present procedures produced a 44% reduction in eating the novel food on the part of Group H animals which is similar to the magnitude of previous taste aversions for novel liquids. McGowan, Hankins, & Garcia (1972) found that rats with ventral hippocampal lesions reduced their intake of a saccharin solution by approximately 40% after it was paired with internal malaise and that rats with dorsal hippocampal lesions reduced their intake of the same solution by approximately 30%. In addition, Murphy and Brown (I974) demonstrated a learned taste aversion to sucrose with rats with bilateral hippocampal lesions reducing their intake by 60%.…”

Section: Discussionmentioning

confidence: 99%

“…Attention has recently been given to the effects of hippocampal lesions on learned taste aversions (Best & Orr, 1973: McGowan, Hankins, & Garcia, 1972: Murphy & Brown, 1974. In all of the studies which examined this effect, the taste of a solution was the CS which was paired with a noxious UCS.…”

mentioning

confidence: 99%

The effect of hippocampal lesions on the development and extinction of a learned taste aversion for a novel food

Thomka

Brown

1975

Psychobiology

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The effect of hippocampal lesions on the inhibition of eating was examined within a learned taste aversion paradigm. Rats with hippocampal lesions were tested on their ability to refrain from eating a novel tasting food that had been paired with the internal malaise produced by a .15·M IP injection of lithium chloride. The results showed that the rats with hippocampal lesions did not differ from normal rats on either the development or extinction of the aversion. These results extend previous findings which show that bilateral hippocampal lesions do not interfere with the normal modulation of consummatory behaviors.

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Limbic lesions and control of the internal and external environment

Cited by 186 publications

References 21 publications

Baitshyness retention in rats with olfactory-bulb ablations

Baitshyness retention in rats with olfactory-bulb ablations

Amygdaloid lesions block the effect of neuropeptides (vasopressin, ACTH4–10) on avoidance behavior

The effect of hippocampal lesions on the development and extinction of a learned taste aversion for a novel food

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