Limbic cholinergic pathways involved in sleep and emotional behavior

Hernández-Peón, R.; Chávez-Ibarra, G.; Morgane, Peter J.; Timo-Iaria, C.

doi:10.1016/0014-4886(63)90037-2

Cited by 294 publications

(28 citation statements)

References 6 publications

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“…This assumption is consistent with the reports that both electrical (7) and chemical (14) stimulation of this region can induce sleep. Moreover, it is also supported by the observation that symmetric bilateral lesions were required to produce sleeplessness, while unilateral irritative stimulation should be sufficient to produce arousal.…”

supporting

confidence: 93%

Visible Light: Mutagen or Killer?

Margulis

Krinsky²,

Leff³

1968

Science

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supporting

confidence: 93%

Visible Light: Mutagen or Killer?

Margulis

Krinsky²,

Leff³

1968

Science

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“…carpine in the brain. The possibility that pilocarpine stimulates a cholinergic behavioral excitatory system (Hernandez-Peon et al, 1963) after its inhibitory effects have been reduced is negated by the study (Experiment III) showing that scopolamine administered at the end of the inhibitory period actually increased the subsequent hyperactivity. Of course, it is possible that pflocarpine has unspecified non-cholinergie (or possibly non-muscarinic) properties which become manifest after its cholinergically mediated depressive actions have .been reduced.…”

Section: Discussionmentioning

confidence: 97%

A biphasic action of central cholinergic stimulation on behavioral arousal in the rat

Fibiger

Lynch

Cooper

1971

Psychopharmacologia

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Abstract. The effect of the eholinomimetie, pilocarpine, on behavioral arousal as measured by locomotor activity was investigated in the rat. Pilocarpine first produced a period of behavioral inhibition, the intensity and duration of which was dose-related. After the inhibitory phase, a period of marked psychomotor excitation was observed. Pretreatment with scopolamine prevented both the inhibitory and excitatory effects of piloearpine. Scopolamine administered at the onset of the rebound hyperactive period, however, significantly potentiated this excitatory phase. The anticholinesterase, physostigmine, also had a biphasie effect on behavioral arousal. The results are interpreted as indicating induction of central adrenergie activity in response to central cholinergie stimulation.

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“…In the present• experiment, PGD2 had almost no modulatory effect on PHA neuron responses to NA or ACh. Microinjection of NA into the POA (HERNANDEZ-PEON et al, 1963;LoMAx et al, 1969;BECKMAN, 1970) or cerebral ventricle (CoRDEAU et al, 1971;GEYER et al, 1972) produced alertness and hyperthermia, while microinjection of ACh into the POA elicited sleep (HERNANDEZ-PEON et al, 1963) and hypothermia (BECKMAN and CARLISLE, 1969;LoMAx et al, 1969). Moreover, it has been reported that NA suppresses the activity of warm-sensitive neurons and facilitates that of cold-sensitive neurons in the rat (MURAKAMI, 1973) and rabbit (HORI and NAKAYAMA, 1973) POA.…”

Section: Discussionmentioning

confidence: 99%

Effects of prostaglandin D2 on the activity of hypothalamic neurons in the rat.

Inokuchi

Osuga²

1986

Jpn.J.Physiol

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The effects of electrophoretically applied prostaglandin D2 (PGD2) on neuronal activity in the rat lateral preoptic area (LPOA) and posterior hypothalamic area (PHA) were examined. In the LPOA, 20% of the tested neurons were excited, 26% inhibited, and 6% showed bidirectional response. The direct effects often showed desensitization after repeated applications. Neurons excited by PGD2 were significantly sensitive (excitation) to acetylcholine (ACh). The ACh excitatory effect was sometimes (38%) attenuated, blocked, or reversed by concurrent PGD2 application. Excitatory or inhibitory effect of noradrenaline (NA) was not related to the effects of PGD2, however, modulation of the NA responses by PGD2 was common (58%). Inhibition, the predominant NA response, was changed to no effect or to excitation during simultaneous PGD2 application. Changes of the NA responses from inhibition to excitation, or from excitation to inhibition-excitation sequences were observed after PGD2 infusion into the third cerebral ventricle at low concentrations. In 43% of the cells, neurotransmission in the LPOA following ventral noradrenergic bundle stimulation was modified by PGD2 application. PGD2 application tended to reduce the duration of inhibition and to extend that of excitation. The direct effects of PGD2 in the PHA were similar to those in the LPOA. Desensitization was also observed in the PHA, but no interrelations were observed among the effects of PGD2, ACh, and NA. Modulation of ACh and NA responses by PGD2 was rarely seen in the PHA. Possible contributions of PGD2 to sleep and thermoregulation are discussed.

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Limbic cholinergic pathways involved in sleep and emotional behavior

Cited by 294 publications

References 6 publications

Visible Light: Mutagen or Killer?

Visible Light: Mutagen or Killer?

A biphasic action of central cholinergic stimulation on behavioral arousal in the rat

Effects of prostaglandin D2 on the activity of hypothalamic neurons in the rat.

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