Limb development genes underlie variation in human fingerprint patterns

Li, Jinxi; Glover, James D.; Zhang, Haiguo; Ma, Peng; Tan, Jingze; Mallick, Chandana Basu; Hou, Dan; Yang, Yajun; Wu, Sijie; Liu, Yu; Peng, Qianqian; Shi-qing, Zheng; Crosse, Edie I.; Medvinsky, Alexander; Anderson, Richard A.; Brown, Helen; Yuan, Ziyu; Zhou, Shen; Xu, Yunfeng; Kemp, John P.; Ho, Yvonne; Loesch, Danuta Z.; Li-zhong, Wang; Li, Yingxiang; Tang, Senwei; Wu, Xiaoli; Walters, Robin G.; Lin, Kuang; Meng, Ruogu; Lv, Jun; Chernus, Jonathan M.; Neiswanger, Katherine; Feingold, Eleanor; Evans, David M.; Medland, Sarah E.; Martin, Nicholas G.; Weinberg, Seth M.; Marazita, Mary L.; Chen, Gang; Chen, Zhengming; Zhou, Yong; Cheeseman, Michael; Wang, Lan; Li, Jin; Headon, Denis J.; Wang, Sijia

doi:10.1016/j.cell.2021.12.008

Cited by 33 publications

(21 citation statements)

References 130 publications

(114 reference statements)

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“…5 b; Additional file 1 : Table S2). And it can be found that there was a centrally significant correlation between various time points between 1 day and 1 month, which is similar to the “pattern-block” phenomenon [ 18 , 19 ]. When the NFAT family expression at each time point in the trauma group and the control group were correlated together, it was found that there was also a centrally significant correlation between 3 days and 2 weeks after surgery (Fig.…”

Section: Resultsmentioning

confidence: 80%

“…When both groups were analyzed simultaneously, this clustered and significant correlation was found to occur over a period of 3 days to 2 weeks, which is similar to the “pattern-block” phenomenon. This phenomenon was first reported in the study of the clinical manifestations and nucleotide polymorphisms of fingers [ 18 , 19 ]. Scholars found that the clinical phenotypes and nucleotide polymorphisms between the middle fingers had a more significant correlation [ 18 ].…”

Section: Discussionmentioning

confidence: 95%

“…This phenomenon was first reported in the study of the clinical manifestations and nucleotide polymorphisms of fingers [ 18 , 19 ]. Scholars found that the clinical phenotypes and nucleotide polymorphisms between the middle fingers had a more significant correlation [ 18 ]. The appearance of this phenomenon in this study suggests that in the time period within 1 month, the expression of NFAT families is more significantly correlated.…”

Section: Discussionmentioning

confidence: 95%

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Dynamic transcriptome analysis of NFAT family in guided bone regeneration with occlusive periosteum in swine model

Yin

Wang

et al. 2022

J Orthop Surg Res

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Objective To investigate the dynamic expression of NFAT family of periosteum in guided bone regeneration process. Material and methods The swine ribs on one side were used as the trauma group and the contralateral side as the control group. After rib segment was removed, periosteum was sutured to form a closed cavity mimicking guided bone regeneration. The periosteum and regenerated bone tissue were collected at nine time points for gene sequencing and hematoxylin–eosin staining. The expression data of each member were extracted for analysis. Expression correlations among various members were analyzed. Results Staining showed the guided bone regeneration was almost completed 1 month after the operation with later stage for bone remodeling. The expression levels of each member in both groups changed greatly, especially within postoperative 1.5 months. The expression of NFATc1 and NFATC2IP in trauma group was significantly correlated with those of control group. The foldchange of each member also had large fluctuations especially within 1.5 months. In the trauma group, NFATc2 and NFATc4 were significantly upregulated, and there was a significant aggregation correlation of NFAT family expression between the various time points within one month, similar to the “pattern-block” phenomenon. Conclusion This study revealed the dynamic expression of NFAT family in guided bone regeneration, and provided a reference for the specific mechanism. The first 1.5 months is a critical period and should be paid attention to. The significant high-expression of NFATc2 and NFATc4 may role importantly in this process, which needs further research to verify it.

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Section: Resultsmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Dynamic transcriptome analysis of NFAT family in guided bone regeneration with occlusive periosteum in swine model

Yin

Wang

et al. 2022

J Orthop Surg Res

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“…In addition to these analyses conducted primarily within CKB, we have contributed to many genome wide association studies in collaboration with major consortia, including trans-ancestry studies of intracranial aneurysm 10 , recurrent miscarriage 11 , blood lipids 50 , fingerprint patterns 51 , diabetes 52 , and height 13 . In particular, CKB has made important contributions to the growing number of studies focussed specifically on populations of East Asian ancestry, including the largest single contribution to a GWAS of depression in East Asians 53 ; and a major contribution to a GWAS of type 2 diabetes, the largest East Asian GWAS to date 54 .…”

Section: Introductionmentioning

confidence: 99%

Genotyping and population structure of the China Kadoorie Biobank

Walters

Millwood

Lin

et al. 2022

Preprint

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China Kadoorie Biobank is a population-based prospective cohort of >512,000 adults recruited in 2004-2008 from 10 geographically diverse regions across China. Detailed data from questionnaire and physical measurements were collected at baseline, with additional measurements at three resurveys involving approximately 5% of surviving participants. Incident disease events are captured through electronic linkage to death and disease registries and to the national health insurance system. Genome-wide genotyping has been conducted for >100,000 participants using custom-designed Axiom® arrays. Analysis of these data reveals extensive relatedness within the CKB cohort, signatures of recent consanguinity, and principal component signatures reflecting large-scale population movements from recent Chinese history. In addition to numerous CKB studies of candidate drug targets and disease risk factors, CKB has made substantial contributions to many international genetics consortia. Collected biosamples are now being used for high-throughput 'omics assays which, together with planned whole genome sequencing, will continue to enhance the scientific value of this biobank.

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“…Moreover, researchers were paying more attention to the relationship between human macro and micro fields, especially human development phenotypes. Recently, Li et al (2022) maintained that fingerprint patterns were genetically related to hand and finger proportions. Nevertheless, studies on human microbiota and developmental phenotypes were rare.…”

Section: Introductionmentioning

confidence: 99%

Impacts of Delivery Mode and Maternal Factors on Neonatal Oral Microbiota

Yan

Sun

et al. 2022

Front. Microbiol.

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ObjectivesInitial oral microbial colonization has complicatedly interacted with growth and development. The aim of our study was to discover links between oral microbiota community structure and mode of delivery, maternal factors, such as systemic diseases, abortion history, and pregnancy complications.MethodsA total of 177 pregnant women and their neonates were enrolled at Peking university people’s hospital. We collected oral samples, medical history, and development phenotype and used a 16S rRNA gene sequence to analyze microbial diversity at all taxonomic levels, network structure, and metabolic characteristics.ResultsFirmicutes, Proteobacteria, and Actinobacteriota were the most predominant bacteria of neonatal oral samples among these phyla. Alpha-diversity of pregnant women with gestational diabetes mellitus (GDM), abortion history, and without immune diseases was higher than in control groups, and no significant dissimilarity in beta-diversity was observed between different maternal factors. Obvious separation or trend failed to be seen in different development phenotype groups. Besides, Oscillospirales were significantly more abundant in a natural delivery group than in the cesarean section group.ConclusionOur study indicated that maternal factors and mode of delivery influenced the oral microbial structure, but longitudinal studies were indispensable for capturing the long-term effects on neonatal development phenotype and oral microbiota.

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Limb development genes underlie variation in human fingerprint patterns

Cited by 33 publications

References 130 publications

Dynamic transcriptome analysis of NFAT family in guided bone regeneration with occlusive periosteum in swine model

Dynamic transcriptome analysis of NFAT family in guided bone regeneration with occlusive periosteum in swine model

Genotyping and population structure of the China Kadoorie Biobank

Impacts of Delivery Mode and Maternal Factors on Neonatal Oral Microbiota

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