Limb Apraxia: a Disorder of Learned Skilled Movement

Foundas, Anne L.; Duncan, E. Susan

doi:10.1007/s11910-019-0989-9

Cited by 21 publications

(11 citation statements)

References 85 publications

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“…Functional neuroimaging studies in healthy subjects and lesion data have consistently emphasized the involvement of a distributed bilateral parietotemporal-frontal network subserving gesture processing in praxis-related tasks (Buxbaum, Shapiro, & Coslett, 2014;Caspers, Zilles, Laird, & Eickhoff, 2010;Goldenberg, Hermsdörfer, Glindemann, Rorden, & Karnath, 2007;Leiguarda & Marsden, 2000;Lesourd et al, 2018;Niessen, Fink, & Weiss, 2014). This 'praxis network' engages the inferior and superior parietal lobes, temporal areas, as well as motor cortices and inferior frontal regions (Foundas & Duncan, 2019;Leiguarda & Marsden, 2000). Subcortical regions, including the basal ganglia and thalamus, have also been implicated (Leiguarda, 2001).…”

Section: Introductionmentioning

confidence: 99%

Altered Gesture Imitation and Brain Anatomy in Adult Prader–Willi Syndrome Patients

Caixàs

Blanco‐Hinojo

Pujol

et al. 2021

J Int Neuropsychol Soc

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Objective: To explore motor praxis in adults with Prader–Willi syndrome (PWS) in comparison with a control group of people with intellectual disability (ID) and to examine the relationship with brain structural measurements. Method: Thirty adult participants with PWS and 132 with ID of nongenetic etiology (matched by age, sex, and ID level) were assessed using a comprehensive evaluation of the praxis function, which included pantomime of tool use, imitation of meaningful and meaningless gestures, motor sequencing, and constructional praxis. Results: Results support specific praxis difficulties in PWS, with worse performance in the imitation of motor actions and better performance in constructional praxis than ID peers. Compared with both control groups, PWS showed increased gray matter volume in sensorimotor and subcortical regions. However, we found no obvious association between these alterations and praxis performance. Instead, praxis scores correlated with regional volume measures in distributed apparently normal brain areas. Conclusions: Our findings are consistent in showing significant impairment in gesture imitation abilities in PWS and, otherwise, further indicate that the visuospatial praxis domain is relatively preserved. Praxis disability in PWS was not associated with a specific, focal alteration of brain anatomy. Altered imitation gestures could, therefore, be a consequence of widespread brain dysfunction. However, the specific contribution of key brain structures (e.g., areas containing mirror neurons) should be more finely tested in future research.

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Section: Introductionmentioning

confidence: 99%

Altered Gesture Imitation and Brain Anatomy in Adult Prader–Willi Syndrome Patients

Caixàs

Blanco‐Hinojo

Pujol

et al. 2021

J Int Neuropsychol Soc

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“…As apraxia is thought to be a cortical cognitive disorder [39], the severity of apraxia should mainly be related to cognitive dysfunction. Correlation analyses confirmed that lower DATE scores indicating more apraxia were associated with lower cognitive function for nearly all cognitive measures analysed.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Evaluation of the Dementia Apraxia Test in Parkinson’s Disease Patients

Renftle

Becker

Brockmann

et al. 2022

Dement Geriatr Cogn Disord

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Introduction: Ideomotor apraxia, a disorder of skilled movements affecting limbs and/or face, can be seen in patients with Parkinson’s disease (PD), yet tests of apraxia in PD are rare. The aim of this project was to evaluate the psychometric properties and validity of the Dementia Apraxia Test (DATE) in a PD sample. Methods: 118 PD patients were included. Besides DATE performance, motor and non-motor burden, cognition, and activity of daily living (ADL) function were assessed. Patients were classified as cognitively impaired (n = 41) or non-cognitively impaired (n = 77). Results: Interrater reliability of the DATE (sub-)scores between video ratings and on-site ratings by the investigator was good (0.81 ≤ rk ≤ 0.87). Items were mostly easy to perform, especially the buccofacial apraxia items, which had also low discriminatory power. DATE scores were associated with cognition and ADL function. DATE performance was confounded by motor impairment and patients’ age; however, when analysed for both cognitive groups separately, the correlation between DATE and motor performance was not significant. Discussion/Conclusion: The DATE seems to be an objective and predominantly valid apraxia screening tool for PD patients, with a few items needing revision. Due to the potential effect of motor impairment and age, standardized scores adjusting for these confounders are needed.

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“…The average time post-stroke at admission to the Neurological-Neurosurgical Early Rehabilitation program was 5.0 days (SD = 3.7). The interval between the assessments at admission and discharge was, on average, 12.2 days (SD = 3.9, range [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. The interval between the midterm and discharge assessments was 7.9 days (SD = 4.4, range 1-19).…”

Section: Demographic and Clinical Characteristics Of The Patient Samplementioning

confidence: 99%

“…30–50% after LH and 8–20% after RH stroke [ 39 ]. Although some previous studies suggested an impact of apraxia on functional outcomes, the results remain ambiguous: According to some studies, apraxia led to more pronounced ADL impairments [ 11 ], a more significant caregiver burden [ 16 ], and a poorer functional outcome [ 46 ]. In contrast, other studies failed to show a relevant effect of bucco-facial or limb apraxia on functional outcomes after stroke [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of apraxia and neglect on early rehabilitation outcome after stroke

Latarnik

Stähl

Vossel

et al. 2022

Neurol. Res. Pract.

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Background This study aims to characterize the impact of apraxia and visuospatial neglect on stroke patients’ cognitive and functional outcomes during early rehabilitation. Prior work implies an unfavorable effect of visuospatial neglect on rehabilitation; however, previous findings remain ambiguous and primarily considered long-term effects. Even less is known about the impact of apraxia on rehabilitation outcomes. Although clinicians agree on the significance of the first few weeks after stroke for the course of rehabilitation, studies exploring the impact of neglect and apraxia in this early rehabilitation period remain scarce. Methods Based on a screening of 515 hospitalized stroke patients from an early rehabilitation ward, 150 stroke patients (75 left-hemispheric strokes, 75 right hemispheric strokes) fulfilled the inclusion criteria and were enrolled in this observational, longitudinal study. The patients’ cognitive and functional statuses were documented at admission to the early rehabilitation ward and discharge. Also, detailed apraxia and neglect assessments were performed at midterm. The predictive values of age and apraxia and neglect severity (as reflected in two components from a principal component analysis of the neglect and apraxia assessments) for cognitive and functional outcomes at discharge were evaluated by multiple regression analyses. Results Besides the expected influence of the respective variables at admission, we observed a significant effect of apraxia severity on the cognitive outcome at discharge. Moreover, neglect severity predicted the Early Rehabilitation Barthel Index (Frühreha-Barthel-Index) at discharge. Supplementary moderator analysis revealed a differential effect of neglect severity on the cognitive outcome depending on the affected hemisphere. Conclusion Data indicate a strong association between apraxia and visuospatial neglect and early rehabilitation outcomes after stroke.

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Limb Apraxia: a Disorder of Learned Skilled Movement

Cited by 21 publications

References 85 publications

Altered Gesture Imitation and Brain Anatomy in Adult Prader–Willi Syndrome Patients

Altered Gesture Imitation and Brain Anatomy in Adult Prader–Willi Syndrome Patients

Evaluation of the Dementia Apraxia Test in Parkinson’s Disease Patients

The impact of apraxia and neglect on early rehabilitation outcome after stroke

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