Limb and face apraxias in frontotemporal dementia: A systematic scoping review

Yliranta, Aino; Jehkonen, Mervi

doi:10.1016/j.cortex.2020.03.023

Cited by 9 publications

(4 citation statements)

References 93 publications

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“…A recent systematic scoping review compiled the evidence regarding limb and face apraxia in PPA (Yliranta & Jehkonen, 2020). The authors reported that limb apraxia has been identified in all 3 variants of PPA, with an overlapping range of apraxia frequency reported in each variant: 40%-58% in nfvPPA, 36%-67% in lvPPA, and 69%-90% in svPPA.…”

Section: Introductionmentioning

confidence: 99%

“…Primary progressive aphasia (PPA) is a clinical syndrome caused by neurodegenerative disease such as frontotemporal dementia or Alzheimer’s disease that is characterized by progressive language deficits with relative sparing of other cognitive domains (Gorno-Tempini et al, 2011; Mesulam, 2003). However, it is also recognized that aspects of cognition and praxis may be deficient in PPA along with language (de la Sablonnière et al, 2021; Joshi et al, 2003; Yliranta & Jehkonen, 2020). There are three widely recognized clinical variants of PPA that are distinguished by their functional deficits and sites of neural atrophy.…”

Section: Introductionmentioning

confidence: 99%

“…Limb apraxia – a disorder of skilled movements not attributable to sensory, motor, or language deficits – frequently co-occurs with PPA (Yliranta & Jehkonen, 2020; Buxbaum & Kalénine, 2021). Limb apraxia can affect skilled action production, imitation, recognition, and/ or tool use.…”

Section: Introductionmentioning

confidence: 99%

“…However, svPPA was uniquely characterized by deficits on tasks that required action semantic knowledge (e.g., action matching tasks). Individuals with svPPA also uniquely showed increased production of content errors (i.e., perplexity or unrecognizable gestures) with less substantial deficits in the spatiotemporal aspects of gesture (Yliranta & Jehkonen, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Gesture profiles distinguish primary progressive aphasia variants

Dresang

Williamson

Kim

et al. 2023

Preprint

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Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by progressive language deficits. The main variants of PPA - semantic (svPPA), logopenic (lvPPA), and nonfluent (nfvPPA) - can be challenging to distinguish. Limb apraxia often co-occurs with PPA, but it is unclear whether PPA variants are associated with different apraxia patterns. Prior evidence from stroke indicates that temporal lobe lesions are associated with reduced benefit of meaning in gesture imitation tasks and disproportionate deficits in imitation of object manipulation-related hand postures compared to arm kinematics. We tested the hypothesis that svPPA - who primarily exhibit temporal lobe atrophy - would differentially show this pattern. Participants with PPA completed meaningful and meaningless gesture imitation tasks. Performance was scored for hand posture and arm kinematics. Mixed-effect models controlling for dementia severity showed showed a critical interaction between variant, meaning, and gesture component: unlike lvPPA and nfvPPA, svPPA's hand postures failed to benefit from gesture meaning. This research extends prior findings on the role of the temporal lobe in action representations associated with manipulable objects, and is the first to indicate distinct gesture imitation patterns as a function of PPA variant. Characterizing gesture deficits in PPA may help inform diagnostics, compensatory communication strategies, and models of praxis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gesture profiles distinguish primary progressive aphasia variants

Dresang

Williamson

Kim

et al. 2023

Preprint

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Co-speech Gesture Production in Spoken Discourse Among Speakers with Acquired Language Disorders

Chick,

Garrard,

Buxbaum

et al. 2023

Spoken Discourse Impairments in the Neurogenic Populations

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Facial emotion expressivity in patients with Parkinson’s and Alzheimer’s disease

Cannavacciuolo,

Paparella,

Salzillo

et al. 2023

J Neural Transm

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Parkinson’s disease (PD) and Alzheimer’s disease (AD) are neurodegenerative disorders with some overlapping clinical features. Hypomimia (reduced facial expressivity) is a prominent sign of PD and it is also present in AD. However, no study has experimentally assessed hypomimia in AD and compared facial expressivity between PD and AD patients. We compared facial emotion expressivity in patients with PD, AD, and healthy controls (HCs). Twenty-four PD patients, 24 AD patients and 24 HCs were videotaped during neutral facial expressions and while posing six facial emotions (anger, surprise, disgust, fear, happiness, and sadness). Fifteen raters were asked to evaluate the videos using MDS-UPDRS-III (item 3.2) and to identify the corresponding emotion from a seven-forced-choice response format. We measured the percentage of accuracy, the reaction time (RT), and the confidence level (CL) in the perceived accuracy of the raters’ responses. We found the highest MDS-UPDRS 3.2 scores in PD, and higher in AD than HCs. When evaluating the posed expression captures, raters identified a lower percentage of correct answers in the PD and AD groups than HCs. There was no difference in raters’ response accuracy between the PD and AD. No difference was observed in RT and CL data between groups. Hypomimia in patients correlated positively with the global MDS-UPDRS-III and negatively with Mini Mental State Examination scores. PD and AD patients have a similar pattern of reduced facial emotion expressivity compared to controls. These findings hold potential pathophysiological and clinical implications.

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Limb and face apraxias in frontotemporal dementia: A systematic scoping review

Cited by 9 publications

References 93 publications

Gesture profiles distinguish primary progressive aphasia variants

Gesture profiles distinguish primary progressive aphasia variants

Co-speech Gesture Production in Spoken Discourse Among Speakers with Acquired Language Disorders

Facial emotion expressivity in patients with Parkinson’s and Alzheimer’s disease

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