LIM-kinase 1 in regulation of cognitive and locomotor functions of Drosophila melanogaster

Abstract

Background: LIM-kinase 1 is the key enzyme of actin remodeling which is necessary for synaptic plasticity during learning and memory formation. Deletion of limk1 leads to the development of Williams syndrome, accompanied by cognitive impairment and motor dysfunction, which refers to cytoskeleton diseases – cofilinopatia. Cofilinopatias are characterized by the formation of cofilin-actin complexes in neurons that disrupt vesicular transport and identify the early stages of dementia. Conclusion: In the present article, we briefly reviewed data about role of LIMK1 function in communicative sound production during courtship behavior, learning acquisition and memory formation.