In this paper, to achieve the available spatial, temporal, and frequency diversities, and also to make the system implementation feasible for high-speed orthogonal frequency division multiplexing multiple-input multiple-output multiplexing, a novel layered space-time-frequency (LSTF) transmitter architecture with multiple channel encoders is proposed with each independently coded information sub-stream being threaded in the three-dimensional (3-D) space-time-frequency transmission resource array. The performance of a non-iterative receiver consisting of a maximum-likelihood detector with QR decomposition and M-algorithm maximum-likelihood detection is exploited, by employing irregular low-density paritycheck code as the channel code. The threaded distribution of each coded information sub-stream in the proposed LSTF architecture makes it achieve the spatial, temporal, and frequency diversities the same as the conventional single-encoder LSTF architecture where coding is applied across the whole information stream, and simulation results show that the performance of the proposed multiple-encoder LSTF architecture is very close to that of the conventional single-encoder LSTF architecture. However, because of the use of multiple parallel encoders/decoders with a shorter codeword length, the proposed LSTF architecture has much lower hardware processing speed and complexity than that of the conventional LSTF architecture.