Like beauty and contact lenses, the meaning of dementia behavioral changes is in the eyes of the beholder

Werner, Perla

doi:10.1017/s104161022200120x

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2024

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“…Furthermore, many people experience Alzheimer's in their lives as family members and friends of those with this disease. The general symptoms of AD are variations in thinking, memory and a behavior known as dementia [12][13][14]. This is why the term "dementia" is occasionally used to refer to Alzheimer's.…”

Section: Introductionmentioning

confidence: 99%

Molecular Role of Protein Phosphatases in Alzheimer’s and Other Neurodegenerative Diseases

Hassan,

Yasir,

Shahzadi

et al. 2024

Biomedicines

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Alzheimer’s disease (AD) is distinguished by the gradual loss of cognitive function, which is associated with neuronal loss and death. Accumulating evidence supports that protein phosphatases (PPs; PP1, PP2A, PP2B, PP4, PP5, PP6, and PP7) are directly linked with amyloid beta (Aβ) as well as the formation of the neurofibrillary tangles (NFTs) causing AD. Published data reported lower PP1 and PP2A activity in both gray and white matters in AD brains than in the controls, which clearly shows that dysfunctional phosphatases play a significant role in AD. Moreover, PP2A is also a major causing factor of AD through the deregulation of the tau protein. Here, we review recent advances on the role of protein phosphatases in the pathology of AD and other neurodegenerative diseases. A better understanding of this problem may lead to the development of phosphatase-targeted therapies for neurodegenerative disorders in the near future.

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Section: Introductionmentioning

confidence: 99%