Abstract:Ligustrazine potently inhibits hypoxic pulmonary vasoconstriction. This effect can be mimicked by the sulphonylurea tolbutamide, a blocker of ATP-sensitive K' channels. Here we demonstrate that ligustrazine is a specific blocker of ATP-sensitive K+ channels in mouse pancreatic fi cells.This suggests that ligustrazine may act in the pulmonary circulation by blocking ATP-sensitive K+ channels.
“…Several studies have shown that ligustrazine, an alkaloid extracted from Ligusticum wallichii Franch, is a potent blocker of vasoconstriction [11]. Ligustrazine also has strong effects of scavenging cytotoxic oxygen free radicals [12].…”
“…Several studies have shown that ligustrazine, an alkaloid extracted from Ligusticum wallichii Franch, is a potent blocker of vasoconstriction [11]. Ligustrazine also has strong effects of scavenging cytotoxic oxygen free radicals [12].…”
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