Ligustilide, A Novel Senolytic Compound Isolated from the Roots of Angelica Acutiloba
Kento Takaya,
Kazuo Kishi
Abstract:Senescent cells accumulate with age and contribute to age‐related diseases and organ dysfunctions. Early evidence suggests that removal of senescent cells using senolytic drugs improves the aging phenotype in mice and may improve the health of individuals with chronic diseases. Signs of skin aging, including wrinkles, and sagging, occur largely due to the accumulation of senescent fibroblasts within the dermis; However, there is currently no skin treatment that eliminates senescent cells. In this study, human … Show more
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