Ligusticum wallichi-induced vasorelaxation mediated by mitogen-activated protein kinase in rat aortic smooth muscle

Kim, Junghwan; Kim, Aeran; Kim, Yoon-Sun; Lee, Youn Ri; Bae, Young Min; Cho, SungIl; Rhyu, Mee-Ra

doi:10.1016/j.jep.2003.11.003

Cited by 10 publications

(12 citation statements)

References 21 publications

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“…Some drugs are also known to contract smooth muscle 2,3) . Many previous studies, including our own, have reported on signal transduction mechanisms and smooth muscle contractions [4][5][6][7][8][9][10][11][12][13][14] . In spite of the importance of the smooth muscle in the fields of cardiovascular physiotherapy, obstetrics, and clinical methods, there is still a need for more research [15][16][17] .…”

Section: Introductionmentioning

confidence: 88%

“…Moreover, it is reported that MAPK is directly involved in fluctuations in smooth muscle contraction induced by stimulants such as endothelin-1 (ET-1) and norepinephrine ( Fig. 6) 7,8) . There are four types of MAPK: extracellular signal-regulated protein kinase 1 and 2 (ERK1/2), p38 mitogen-activated protein kinase (p38 MAPK), stressactivated protein kinase/c-Jun N-terminal kinase (SAPK/ JNK), and big MAPK-1 (BMK1), also known as extracellular signal-regulated protein kinase 5 (ERK5) 51,52) .…”

Section: ) Mitogen-activated Protein Kinase (Mapk) Pathway Involvemementioning

confidence: 99%

“…The Ca 2+ -independent pathway of PKC and inhibition of MLCP activation through ROCK and the Ca 2+ -independent pathway of MAPK are involved in this form of muscle contraction (Fig. 6A) 2,7,8,19) .…”

Section: ) Smooth Muscle Contraction and Ca 2+ Sensitizationmentioning

confidence: 99%

“…In spite of the importance of the smooth muscle in the fields of cardiovascular physiotherapy, obstetrics, and clinical methods, there is still a need for more research [15][16][17] . The smooth muscle in internal organs plays an important role as a pain transmitter in inflammation, physical stimulation, and pain caused by excessive contraction of internal organs such as the uterus or stomach 6,7,9,10,17) . Given that senile cardiovascular disease occurs as a result of functional or organic changes in vasoconstriction, the importance of physiotherapy and an understanding of smooth muscle contractions is strongly emphasized.…”

Section: Introductionmentioning

confidence: 99%

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A Review of Signal Transduction in Mechanisms of Smooth Muscle Contraction and Its Relevance for Specialized Physical Therapy

Kim

Lee

et al. 2013

J Phys Ther Sci

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Abstract.[Purpose] An understanding of smooth muscle contraction is important in the study of specialized physical therapy. In this paper, we summarize the contraction mechanisms of smooth muscle and suggest their applications in physical therapy. [Method] This review focuses on the signaling pathways that control smooth muscle contraction and its mechanisms. We include results reported by our laboratory in a wider literature review. [Results] Our results and the literature show that various mechanisms of smooth muscle contraction exist. [Conclusions] In this review article, we carefully discuss the signal transduction in smooth muscle contraction based on our studies and with reference to physical therapy.

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Section: Introductionmentioning

confidence: 88%

Section: ) Mitogen-activated Protein Kinase (Mapk) Pathway Involvemementioning

confidence: 99%

Section: ) Smooth Muscle Contraction and Ca 2+ Sensitizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Review of Signal Transduction in Mechanisms of Smooth Muscle Contraction and Its Relevance for Specialized Physical Therapy

Kim

Lee

et al. 2013

J Phys Ther Sci

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“…In clinical findings, myotonic and structural changes of the blood vessel wall, especially, are directly connected with cardiovascular disorders such as hypertension, cerebral hemorrhage and angina 4,7) . Excessive tension of the vascular smooth muscle is induced by hyperactivation of the sympathetic nerves, and phosphorylation of mitogen-activated protein kinases (MAPKs), and remodeling of cells takes place to balance the pathogenic metamorphosis of hypertension 4,8,9) . Previous studies have reported that the controlled release of transmitters and excitement of the sympathetic nerves (using interventions such as stimulus by electronic needle and therapeutic massage to decrease blood pressure) do alleviate pain, and restrain the activity of sympathetic nerves 10,11) .…”

Section: Introductionmentioning

confidence: 99%

Noxiousness of Hypertension-related Norepinephrine and Upregulation of Norepinephrine Induced by High Intensity Electrical Stimulation in Healthy Volunteers

et al. 2012

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Abstract.[Purpose] The purpose of the present study was to assist the design of future experiments on pain therapeutics and to establish the reliability and understanding of animal models of neurotransmitters of sympathetic nerves.[Subjects] The subjects were fifty-five male rats and ten female volunteers. [Methods] In vitro testing of experimental animals, measuring blood pressure, muscle tension, histological changes, intracellular Ca 2+ , and enzymatic activity. We also induced hypertension-related sympathetic effects by physical therapy with high intensity electrical stimulation as evidenced by 24-hour urine analysis of norepinephrine. [Results] In isometric tension and histological analyse, norepinephrine-induced tension and collagen fibers were significantly increased in muscle strips from hypertensive rat aorta. In [Ca 2+ ] i analysis, norepinephrine-induced change of [Ca 2+ ] i in muscle strips from normotensive and hypertensive rat aorta was observed. Analysis by western blotting with anti-phosphorylated antibodies showed that the phosphorylation of ERK1/2 (extracellular signal-regulated protein kinase 1 and 2) and p38 MAPK (p38 mitogen-activated protein kinase) were significantly increased in the norepinephrine-induced state in the rats. Furthermore, high intensity electrical stimulation significantly increased pain-related concentration of norepinephrine in the healthy volunteers.[Conclusion] These results suggest that the application of norepinephrine to aorta muscle strips is associated with changed muscle tension, [Ca 2+ ] i , and phosphorylation of MAPK, and that the increased responsiveness of norepinephrine to high intensity electrical stimulation may be, in part, related to the increase of sympathetic effects.

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Phorbol ester-induced contraction through p38 mitogen-activated protein kinase is diminished in aortas from DOCA-salt hypertensive rats

et al. 2006

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The role of mitogen-activated protein kinase (MAPK) in the decreased contractile response to phorbol ester in aortic smooth muscle strips from deoxycorticosterone acetate (DOCA)-salt hypertensive rats was examined. Norepinephrine (NE) evoked greater contractility in aortic strips from DOCA rats than in those of sham-operated rats. 12-Deoxyphorbol 13-isobutyrate (DPB) induced contraction in Ca2+-free medium, which was diminished in strips from DOCA rats compared to sham-operated rats. Vasoconstrictions induced by these stimulants were inhibited by SB203580 and PD098059, inhibitors of p38 MAPK and extracellular signal-regulated kinase (ERK) 1/2, respectively, in both strips. The phosphorylation of p38 MAPK and ERK1/2 induced by NE was greater in strips from DOCA rats compared to those from sham-operated rats, and this phosphorylation was inhibited by the kinase inhibitors. DPB increased the phosphorylation of p38 MAPK and ERK1/2 in strips from both animals, and the increment of p38 MAPK phosphorylation by the stimulant was diminished in strips from DOCA rats compared to sham-operated rats. These findings suggest that the Ca2+-independent contraction evoked by DPB results from the activation of MAPKs in rat aortic smooth muscle and that the attenuated contractility by DPB in DOCA rat appears to be associated with diminished p38 MAPK activity.

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Ligusticum wallichi-induced vasorelaxation mediated by mitogen-activated protein kinase in rat aortic smooth muscle

Cited by 10 publications

References 21 publications

A Review of Signal Transduction in Mechanisms of Smooth Muscle Contraction and Its Relevance for Specialized Physical Therapy

A Review of Signal Transduction in Mechanisms of Smooth Muscle Contraction and Its Relevance for Specialized Physical Therapy

Noxiousness of Hypertension-related Norepinephrine and Upregulation of Norepinephrine Induced by High Intensity Electrical Stimulation in Healthy Volunteers

Phorbol ester-induced contraction through p38 mitogen-activated protein kinase is diminished in aortas from DOCA-salt hypertensive rats

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