Lignins isolated from Prickly pear cladodes of the species Opuntia fícus-indica (Linnaeus) Miller and Opuntia cochenillifera (Linnaeus) Miller induces mice splenocytes activation, proliferation and cytokines production

Filho, Iranildo José da Cruz; Barros, Bárbara Rafaela da Silva; Aguiar, Lethícia Maria de Souza; Navarro, Claudia D.C.; Ruas, Juliana S.; Lorena, Virgínia Maria Barros de; Rocha, George Jackson de Moraes; Vercesi, Anı́bal E.; Melo, Cristiane Moutinho Lagos de; Maior, Ana Maria Souto

doi:10.1016/j.ijbiomac.2018.09.120

Cited by 32 publications

(23 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The result of this study was corresponding to the previous study which indicated that the lignin extract from O. fícus-indica and O. cochenillifera were capable to induce high cell proliferation during experimental times 36 . In addition, oil extract of O. fícus-indica from Tunisia not only revealed a significant antimicrobial, anti-yeast, and antifungal effect in vitro against bacteria, yeast, and fungi, meanwhile, also demonstrated a good wound healing effect with short scarring time in rat wound healing model 37 .…”

Section: Discussionsupporting

confidence: 88%

Mechanism and inhibitory effects of cactus (Opuntia dillenii) extract on melanocytes and its potential application for whitening cosmetics

Chiu

Cheng

Chan

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Penghu cactus (Opuntia dillenii [Ker.] Haw) is a cactus plant that commonly grows in Penghu Island, Taiwan, Republic of China (ROC). However, still lack of scientific study on the Opuntia dillenii [Ker.] Haw extract on skin-whitening-associated tyrosinase activity and melanin production. The activities of its extract in melanogenesis were investigated in this article. In this experiment, we used an extract from the Penghu cactus (Opuntia dillenii [Ker.] Haw) to study its tyrosinase inhibition, anti-melanin generation, UV-protection effects and wound healing capacity in B16-F10 melanocytes. Without reducing cell growth greatly or causing cell death, 20 g/L cactus extract effectively inhibited the melanin production of B16-F10 cells, and melanogenesis was induced by 3-isobutyl-1-methylxanthine. The cactus extract could also promote cell proliferation. Cactus extract treatment decreased the mRNA expression of insulin-like growth factor 1 (IGF-1) and vascular endothelial growth factor (VEGF) and increased that of transforming growth factor β (TGF-β). Thus, it could reduce cell melanin production and promote cell growth but by also reducing IGF-1 and VEGF mRNA expression, may reduce wound scarring and prevent tumor proliferation and swelling. Increasing TGF-β mRNA expression can help increase collagen to remove wrinkles and help in wound healing. Skin patch test results agreed with in vitro results with B16-F10 melanoma cells. The cactus extract significantly inhibited tyrosinase activity and reduced melanin production, showing a whitening effect on skin tests. Cactus may be a good natural candidate for inhibiting melanin production and promoting cell proliferation.

show abstract

Section: Discussionsupporting

confidence: 88%

Mechanism and inhibitory effects of cactus (Opuntia dillenii) extract on melanocytes and its potential application for whitening cosmetics

Chiu

Cheng

Chan

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Extracts ability to free radical sequestration were measured using the AAT, DPPH and ABTS methods, as described by Cruz-Filho et al (2018)…”

Section: Antioxidant Investigation Aat Dpph and Abts Methodsmentioning

confidence: 99%

Antifungical and immunomodulatory activities from Caesalpinia pulcherrima extracts

et al. 2021

View full text Add to dashboard Cite

Caesalpinia pulcherrima is a species widely used in folk medicine for various diseases such as fever, infections and mouth ulcers. In addition, scientific studies have reported medicinal properties such as antitumor, antiviral, antibacterial and antifungal. Therefore, the objective of this work was to evaluate if organic extracts obtained from leaves of C. pulcherrima have medicinal properties. Three organic extracts were obtained (hexane, ethyl acetate and ethanol) from the leaves collected from the Soxhlet equipment. The characterization was made by GC-MS and UPLC-MS and biological properties as antioxidant (AAT, DPPH, ABTS and lipid peroxidation radicals), antimicrobial, cytotoxicity and immunostimulant (using splenocytes of mice Balb/c) were investigated. Results showed several classes of secondary metabolites, but the ethyl acetate showed more phenols and flavonoids than the other extracts. Extracts showed good results in antioxidant tests, especially the ethyl acetate, but did not show antibacterial activity. The fungal evaluation showed high antifungal properties, especially the hexanic and the ethyl acetate against Candida tropicalis, Aspergillus terreu, Candida krusei and Cryptococcus neoformans strains. Cytotoxicity evaluation showed that under 25 μg/mL are the safety doses that can be used for in vitro tests, besides that, extracts were able to induce cytokine stimulation. These results show that the ethyl acetate extract was the best formulation found in this study to be used against fungal infections, for antioxidant proposes and for promote immunostimulation.

show abstract

“…The lignin was obtained according to the methodology used by Cruz-Filho et al [22], Santos et al [19], Melo et al [23], Arruda et al [15], and Silva et al [20] with few modifications. Initially, 100 g of branches or leaves of Buchenavia viridiflora, ground (80 mesh) was submitted to an aqueous extraction in a reactor in the proportions (g/L) 1:1, in a 2 L reactor, at 60 • C and 1200 rpm, for 1 h. The solid material obtained was submitted to an acid pre-treatment in an autoclave under the following conditions: proportion: 1:1 solid: liquid (g/L), H 3 PO 4 (1 %) at 121 • C for 1 h. The liquid was separated from the resulting solid by filtration.…”

Section: Process Of Extraction and Obtaining Of Ligninmentioning

confidence: 99%

“…Regarding biological activities, these may have antioxidant [15,19,20], lignin-based nanomaterials for early glucose detection [21], immunological [19,22], antimicrobial [23], antitumor [24], antiparasitic [20]. In addition to these applications, they can be used as vehicles for controlled drug delivery [25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications

Araújo

Filho

Santos

et al. 2022

International Journal of Biological Macromolecules

Self Cite

View full text Add to dashboard Cite

Lignins isolated from Prickly pear cladodes of the species Opuntia fícus-indica (Linnaeus) Miller and Opuntia cochenillifera (Linnaeus) Miller induces mice splenocytes activation, proliferation and cytokines production

Cited by 32 publications

References 32 publications

Mechanism and inhibitory effects of cactus (Opuntia dillenii) extract on melanocytes and its potential application for whitening cosmetics

Mechanism and inhibitory effects of cactus (Opuntia dillenii) extract on melanocytes and its potential application for whitening cosmetics

Antifungical and immunomodulatory activities from Caesalpinia pulcherrima extracts

Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications

Contact Info

Product

Resources

About