Lignans' Potential in Pre and Post-onset Type 2 Diabetes Management

Barre, Douglas Edward; Mizier-Barre, Kazimiera A.

doi:10.2174/1573399814666180914094520

Cited by 12 publications

(9 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increasing evidence revealed lignan‐rich food like flexseed, sesame seed as well as sesamin, secoisolariciresinol diglucosid, and secoisolariciresinol could reduce plasma glucose level through increasing the glucose uptake, insulin sensitivity, and insulin secretagogue activity. [ 14–16 ] As discussed above, the excess glucose is stored in the liver and skeletal muscles as glycogen. Skeletal muscles, on the other hand, are the primary tissue in which insulin stimulates glucose absorption to eliminate glucose from the bloodstream, with the glucose taken up being integrated into glycogen.…”

Section: Resultsmentioning

confidence: 99%

Lariciresinol Displays Anti‐Diabetic Activity through Inhibition of α‐Glucosidase and Activation and Enhancement of Insulin Signaling

Alam

Lim

et al. 2022

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope: The aim of this study is to investigate the antidiabetic effect of lariciresinol (LSR) in C2C12 myotubes and streptozotocin (STZ)-induced diabetic mice. Methods and results: To investigate antidiabetic potential of LSR, 𝜶-glucosidase inhibitory assay, molecular docking, glucose uptake assay, western blot assay on antidiabetic biomarkers are performed. STZ-induced diabetic model is used for in vivo study by calculating oral glucose tolerance test, histochemical examination, and glycogen assay. LSR inhibits 𝜶-glucosidase activity with an IC 50 value of 6.97 ± 0.37 µM and acts as a competitive inhibitor with an inhibitory constant (Ki) value of 0.046 µM. In C2C12 cells, LSR activates insulin signaling leading to glucose transporter 4 (GLUT4) translocation and augmented glucose uptake. Furthermore, in Streptozotocin (STZ)-treated diabetic mice, 3 weeks of oral LSR administration (10 mg kg −1 ) considerably decrease blood glucose levels, while increasing insulin levels in an oral glucose tolerance test, improve pancreatic islet size, increase GLUT4 expression, and significantly enhance insulin signaling in skeletal muscle. LSR treatment also activates glycogen synthase kinase 3𝜷 (GSK-3𝜷) resulting in improved glycogen content. Conclusion: The findings indicate a potential usefulness for oral LSR in the management and prevention of diabetes by enhancing glucose homeostasis.

show abstract

Section: Resultsmentioning

confidence: 99%

Lariciresinol Displays Anti‐Diabetic Activity through Inhibition of α‐Glucosidase and Activation and Enhancement of Insulin Signaling

Alam

Lim

et al. 2022

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…The antidiabetic effects exerted by lignans may be mediated by improvements in central obesity [ 36 ]. Other potential mechanisms of action include an inhibition of α-amylase and α-glucosidase, improvements in insulin sensitivity, activation of AMPk and GLUT4 receptors, and acting as antagonists of adiponectin receptors [ 37 ]. Associated improvements in fasting plasma glucose levels in non-diabetic patients have also been observed [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial

et al. 2022

View full text Add to dashboard Cite

Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 ± 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D.

show abstract

“…Many classical lignans have been isolated from food such as sesame, whole-grain cereals, and legumes. Lignan-rich diets have been shown to protect against cardiovascular diseases and diabetes [ 14 , 15 ]. In addition, neolignans isolated from Magnolia bark, such as magnolol and honokiol, exhibit efficient effects on inhibiting or preventing the growth of various cancers [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Ailanthoidol, a Neolignan, Suppresses TGF-β1-Induced HepG2 Hepatoblastoma Cell Progression

Tseng

Lee

et al. 2021

Biomedicines

View full text Add to dashboard Cite

Ailanthoidol (ATD), a neolignan, possessed an antitumor promotion effect in the mouse skin model in our previous investigation. However, other antitumor properties remain to be elucidated. Liver cancer is a major cause of death in the world, and its prognosis and survival rate are poor. Therefore, the prevention and therapy of liver cancer have received much attention. TGF (transforming growth factor)-β1, a cytokine, plays a critical role in the progression of liver cancer. This study determined the inhibitory effects of ATD on the migration and invasion induced by TGF-β1 in HepG2 hepatoblastoma cells. Furthermore, ATD reduced the TGF-β1-promoted colony number of HepG2 hepatoblastoma cells. In addition to reversing TGF-β1-induced cell scattering, ATD suppressed TGF-β1-induced expression of integrin α3, vimentin, N-cadherin, and matrix metalloproteinase 2 (MMP2). Finally, this study found that ATD significantly inhibited TGF-β1-promoted phosphorylation of p-38 mitogen-activated protein kinase (MAPK) and Smad 2. Furthermore, the administration of SB203580 (p38MAPK inhibitor) suppressed TGF-β1-induced expression of integrin α3, N-cadherin, and MMP2. These results demonstrate a novel mechanism of ATD against progression of liver cancer.

show abstract

Lignans' Potential in Pre and Post-onset Type 2 Diabetes Management

Cited by 12 publications

References 106 publications

Lariciresinol Displays Anti‐Diabetic Activity through Inhibition of α‐Glucosidase and Activation and Enhancement of Insulin Signaling

Lariciresinol Displays Anti‐Diabetic Activity through Inhibition of α‐Glucosidase and Activation and Enhancement of Insulin Signaling

Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial

Ailanthoidol, a Neolignan, Suppresses TGF-β1-Induced HepG2 Hepatoblastoma Cell Progression

Contact Info

Product

Resources

About