Lignans from Santalum album and Their Cytotoxic Activities

Matsuo, Yukiko; Mimaki, Yoshihiro

doi:10.1248/cpb.58.587

Cited by 33 publications

(17 citation statements)

References 17 publications

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“…The essential oil obtained from sandalwood is widely used as an antidepressant, an anti-inflammatory, an antifungal, an antiviral, and an astringent. 18,37 It is also cooling and aromatic. 38 …”

Section: Discussionmentioning

confidence: 99%

Novel Wound Healing Powder Formulation for the Treatment of Venous Leg Ulcers

Ghatnekar

Elstrom²,

Ghatnekar

et al. 2011

The Journal of the American College of Certified Wound Speciali

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Chronic venous disorders are common in the Western world. The current treatment of venous leg ulcers is unsatisfactory despite the availability of well-documented standards of care. Patients today are interested in alternative approaches to modern medicine. We have developed a wound-healing powder containing natural ingredients with absorptive, aromatic, antiseptic, and anti-inflammatory synergistic properties. This report describes 3 cases that were successfully treated with the powder, demonstrating the potential of herbal remedies in the clinical treatment of venous leg ulcers.

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Section: Discussionmentioning

confidence: 99%

Novel Wound Healing Powder Formulation for the Treatment of Venous Leg Ulcers

Ghatnekar

Elstrom²,

Ghatnekar

et al. 2011

The Journal of the American College of Certified Wound Speciali

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“…The EtOAc residue was purified by preparative TLC using CHCl 3 -MeOH (10 : 1) to yield 6 (1.3 mg). 15) Briefly, HL-60 cells were maintained in an RPMI-1640 medium; A549 and TIG-3 cells were maintained in MEM; and HSC-2 and HSC-4 cells were maintained in DMEM. The media contained heat-inactivated 10% (v/v) FBS supplemented with L-glutamine, penicillin G sodium salt (100 units/mL), and streptomycin sulfate (100 µg/mL).…”

Section: Methodsmentioning

confidence: 99%

“…15) Briefly, HL-60 cells (2×10 6 cells/mL) were treated with a compound for 16 h and the cells were centrifuged and collected. The cell lysate (50 µL, equivalent to 200 µg of protein) was mixed with reaction buffer (2×50 µL) containing the substrates for caspase-3 (DEVD-pNA).…”

Section: Methodsmentioning

confidence: 99%

“…[9][10][11] However, β-santalol, another major volatile sesquiterpene from S. album with the same bicyclo[2.2.1] heptane skeleton, shows few biological activities, including anti-Helicobacter pylori 12) and antiviral effects. 13) We have reported that a methanolic extract of S. album heartwood exhibited cytotoxicity against HL-60 cells with an IC 50 value of 2.1 µg/mL and isolated new α-santalol derivatives 14) and lignans, 15) some of which induced apoptotic cell death in HL-60 and A549 cells. These results prompted us to investigate the heartwood of S. album further.…”

mentioning

confidence: 99%

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A Rare Type of Sesquiterpene and β-Santalol Derivatives from <i>Santalum album</i> and Their Cytotoxic Activities

2014

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A rare type of sesquiterpene with a spiro bicyclic system (1) and seven new (2-8) and four known (9-12) β -santalol derivatives were isolated from the heartwood of Santalum album (Santalaceae). The structures of these new compounds were determined by analysis of extensive spectroscopic data. The isolated compounds and derivatives were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells, A549 human lung adenocarcinoma cells, HSC-2 and HSC-4 human oral squamous cell carcinoma cell lines, and TIG-3 normal human diploid fibroblasts. cis-β -Santalol (9) and β -santaldiol (10) induced apoptotic cell death in HL-60 cells.

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“…Cendana (Santalum album Linn) merupakan salah satu sumberdaya hayati yang memiliki potensi penggunaan secara luas, diantaranya sebagai bahan penyedap makanan, senyawa anti karsiogenik dan antiviral (Burdock & Carabin, 2008), aromatheraphy (Kim et al, 2005;George & Ioana, 2008;Matsuo & Mimaki, 2010), serta anti kanker (Bommareddy et al, 2012). Melalui berbagai ragam potensi pemanfaatan, peningkatan permintaan minyak cendana di pasar internasional terdorong sejak tahun 1800 di USA (Burdock & Carabin, 2008).…”

Section: Pendahuluanunclassified