Lignans from linseed (<i>Linum usitatissimum</i>L.) and its allied species: Retrospect, introspect and prospect

Chhillar, Himanshu; Chopra, Priyanka; Ashfaq, Mohd Ashraf

doi:10.1080/10408398.2020.1784840

Cited by 36 publications

(21 citation statements)

References 208 publications

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“…Flaxseed is one of the richest sources of lignans, followed by cereals and legumes. It contains 800 times more lignans and norlignans than other medicinal plants (9 -30 mg/g) (Chhillar et al 2020;Ganguly et al 2021). Secoisolariciresinol diglucoside (SDG), matairesinol (MAT), secoisolariciresinol (SECO) and lariciresinol diglucoside (LDG) are the most abundant lignans produced by flax (Khan et al 2020).…”

Section: Lignans In Flaxmentioning

confidence: 99%

Biological functions of lignans in plants

Ražná

Nôžková

Vargaová

et al. 2021

Agriculture (Pol'nohospodárstvo)

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Naturally occurring lignans are present in seeds, nuts, cereals, vegetables, and fruits. Lignans play various roles in plants and their multipurpose functions of different organisms including humans is considerable. They are involved in plant defence mechanisms through their antioxidant, antiviral, antibacterial, and antifungal properties. The lignans content may be affected by a variety of factors such as genotype, tissue type, geographic origin, local environmental conditions, nutrition, and plant maturity. Interactive relationships between individual factors are also considered. This review aimed to summarize the biological functions of lignans for plants and empasize the importance of these compounds for the added value of individual genotypes of plant food resources. Understanding the biological functions of lignans in plants can provide solutions to the ever-increasing requirements for the production of functional foods. Flaxseed is the richest source of lignans, and as such is considered the model species for lignans studies. Within our review, one paragraph is focused on the properties and biological functions of flax lignans.

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Section: Lignans In Flaxmentioning

confidence: 99%

Biological functions of lignans in plants

Ražná

Nôžková

Vargaová

et al. 2021

Agriculture (Pol'nohospodárstvo)

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“…Since the compounds effectively inhibited α‐glucosidase, they were further investigated by enzymatic kinetics, fluorescence spectroscopy, and molecular docking analysis to understand better their interaction with the enzyme. In addition, these compounds were found to play a crucial role in preventing and attenuating the onset of many chronic illnesses [30] . Plant‐derived compounds are preferred for the treatment of diseases because they are considered safe, and their availability is not limited.…”

Section: Resultsmentioning

confidence: 99%

Mechanistic Insights into the Inhibitory Activities of Chemical Constituents from the Fruits of Terminalia boivinii on α‐Glucosidase

Dlamini

Chen

et al. 2022

Chemistry & Biodiversity

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Regulation of key digestive enzymes is currently considered an effective remedy for diabetes mellitus. In this study, bioactive constituents were purified from Terminalia boivinii fruits and identified by 1H‐NMR, 13C‐NMR and EI‐MS. In vitro and in silico methods were used to evaluate α‐glucosidase, α‐amylase, and lipase inhibition activities. Compounds 1, 2, and 4–7 with IC50 values between 89 and 445 μM showed stronger α‐glucosidase inhibitory activities than the antihyperglycemic drug acarbose (IC50 =1463.0±29.5 μM). However, the compounds showed lower inhibitory effects against α‐amylase and lipase with IC50 values above 500 μM than acarbose (IC50=16.7±3.5 μM) and ursolic acid (IC50=89.5±5.6 μM), respectively. Lineweaver‐Burk plots showed that compounds 1, 2, and 7 were non‐competitive inhibitors, compounds 4 and 5 were competitive inhibitors and compound 6 was a mixed‐type inhibitor. Fluorescence spectroscopic data showed that the compounds altered the microenvironment and conformation of α‐glucosidase. Computer simulations indicated that the compounds and enzyme interacted primarily through hydrogen bonding. The findings indicated that the compounds were inhibitors of α‐glucosidase and provided significant structural basis for understanding the binding activity of the compounds with α‐glucosidase.

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“…Notably, among all the components, indoles generally exceled in the GI absorption and the DL analysis. In addition, despite bad GI absorption, secoisolariciresinol diglucoside, 32,33 and isovitexin 34 were reported to possess high pharmacological activity, and therefore included in the subsequent network analysis. Seventeen active ingredients were ultimately selected (Table 1 and Figure 3).…”

Section: Prediction Of Active Ingredients In IImentioning

confidence: 99%

A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica

Deng

et al. 2021

DDDT

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Isatis indigotica (Ii) is a cruciferous herb that is widely distributed in China, and its roots and leaves have been used in two renowned antipyretic detoxicate crude drugs in Chinese Pharmacopoeia, Radix (R) and Folium (F) Isatidis. However, the pharmacodynamic material basis and underlying mechanisms of the herbal efficacy remained to be elucidated. Methods: Ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was adopted for the chemical profiling of R and F Isatidis. The active ingredients were screened out through the prediction of gastrointestinal absorption and druglikeness analysis using SwissADME. A herb-ingredient-target network was constructed through target prediction of the herbal active ingredients and anti-inflammation or anti-viral properties, followed by protein-protein interaction analysis. Then, the potential relevant signaling pathways were predicted by pathway enrichment. Finally, for verification, RAW 264.7 cell line was adopted to examine the anti-inflammatory and anti-viral activities of 6 representative ingredients in Ii. Results: Seventy-three compounds have been identified from Ii through UPLC-Q-TOF-MS. A total of 17 potential active ingredients were screened through pharmacokinetics and druglikeness evaluation using SwissADME. It was shown that key targets might include TNF, AKT1, SRC, IL2, CASP9, and CASP3 in our herb-ingredient-target network, and isovitexin, a flavonoid, tended to participate in the inflammatory response, indoles were more likely to affect the cell proliferation processes, and lignans might have a broader affinity to key targets than the other active ingredients, such as regulating immune system (targeting IL-2) and PI3K-Akt signaling pathway. In vitro, indigo and secoisolariciresinol diglucoside markedly reduced TNF-α expression in Poly (I: C)-incubated cells. Isovitexin significantly inhibited TNF-α expression, and isatin treatment markedly reduced IL-1β expression in LPS-incubated cells. Conclusion:As the pharmacodynamics material basis of Ii, indoles, lignans, and flavonoids are believed to confer beneficial properties through various cellular aspects with multiple signaling pathways involved.

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Lignans from linseed (Linum usitatissimumL.) and its allied species: Retrospect, introspect and prospect

Cited by 36 publications

References 208 publications

Biological functions of lignans in plants

Biological functions of lignans in plants

Mechanistic Insights into the Inhibitory Activities of Chemical Constituents from the Fruits of Terminalia boivinii on α‐Glucosidase

A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica

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