Lignans from<i>Trachelospermum jasminoides</i>

Xing-qi, Tan; Chen, Haisheng; Liu, Runhui; Tan, Chen; Xu, Cong-Li; Xuan, Wei-dong; Zhang, Wei‐Dong

doi:10.1055/s-2005-837761

Cited by 26 publications

(15 citation statements)

References 5 publications

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“…These compounds (Fig. ) were identified by 1 H, 13 C NMR and specific rotation, and comparison with literature data (Sakamura et al ., ; Zhang et al ., ; Tan et al ., ; Inagaki et al ., ).…”

Section: Resultsmentioning

confidence: 98%

Potent α‐Glucosidase Inhibitors from Safflower (Carthamus tinctorius L.) Seed

Takahashi

Miyazawa

2011

Phytotherapy Research

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As part of the search for naturally derived α-glucosidase inhibitors, the chemical components isolated from safflower seed (Carthamus tinctorius L.) were evaluated. The compounds active as α-glucosidase inhibitors were serotonin derivatives (e.g. N-p-coumaroyl serotonin (1) and N-feruloyl serotonin (2)). These compounds showed a potent inhibitory activity, the 50% inhibitory concentration (IC(50) ) values were calculated as 47.2 µm (1) and 99.8 µm (2) while that of the reference drugs acarbose and 1-deoxynojirimycin were evaluated as 907.5 µm and 278.0 µm, respectively. Regarding the structure of the serotonin derivative, the existence of the hydroxyl group at 5-position in the serotonin moiety and the linkage of cinnamic acid and serotonin are essential for α-glucosidase inhibitory activities. These results are helpful for the proper use of safflower seed as traditional medicine for the treatment of diabetes, moreover, it could serve to develop medicinal preparations as supplements and functional foods for diabetes. In particular, the serotonin compounds could be used as a lead compound for a new potential α-glucosidase inhibitor derived from the plant.

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Section: Resultsmentioning

confidence: 98%

Potent α‐Glucosidase Inhibitors from Safflower (Carthamus tinctorius L.) Seed

Takahashi

Miyazawa

2011

Phytotherapy Research

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“…Besides, T. liukiuense , T. axillare , T. lucidum, T. fragrans , T. difforme and T. gracilipes are also used for phytochemistry research. Up to now, over 130 compounds have been isolated from the genus Trachelospermum( Table 1 ) , among which lignans (23.9%) [2,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20], triterpenoids (35.5%) [2,21,22,23,24,25,26,27,28,29,30,31], flavonoids (21.7%) [13,21,32,33,34,35,36,37,38,39,40,41,42] are the major categories. All the compounds we summarize are compiled in Table 1.…”

Section: Phytochemistrymentioning

confidence: 99%

Phytochemistry, Pharmacology and Traditional Uses of Plants from the Genus Trachelospermum L.

Zhao

et al. 2017

Molecules

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This paper is intended to review advances in the botanical, phytochemical, traditional uses and pharmacological studies of the genus Trachelospermum. Until now, 138 chemical constituents have been isolated and characterized from these plants, particularly from T. asiaticum and T. jasminoides. Among these compounds, lignans, triterpenoids, and flavonoids are the major bioactive constituents. Studies have shown that plants from the genus Trachelospermum exhibit an extensive range of pharmacological properties both in vivo and in vitro, including anti-inflammatory, analgesic, antitumor, antiviral and antibacterial activities. In Traditional Chinese Medicine (TCM) culture, drugs that include T. jasminoides stems have been used to cure rheumatism, gonarthritis, backache and pharyngitis, although there are few reports concerning the clinical use and toxicity of these plants. Further attention should be paid to gathering information about their toxicology data, quality-control measures, and the clinical value of the active compounds from genus Trachelospermum.

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“…T. jasminoides has been shown to exhibit anti-inflammatory and anti-cancer properties, among others [2][3][4][5]. In advanced pharmacological studies, the total lignan extract from T. jasminoides showed significant anti-inflammatory and analgesic effects [6].…”

Section: Introductionmentioning

confidence: 99%