Lignans from Acanthopanax chiisanensis having an inhibitory activity on prostaglandin E₂ production

Abstract

The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited the significant inhibition of TPA-induced prostaglandin E(2) (PGE(2)) production in rat peritoneal macrophages. Five lignans were isolated from the chloroform fraction and their structures were elucidated as l-sesamin, helioxanthin, savinin, taiwanin C, and 3-(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone. Among the lignans tested, taiwanin C showed the most potent inhibitory activity (IC(50) = 0.12 microM) on PGE(2) production with the relative order of potency, taiwanin C >> 3-(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone > savinin = helioxanthin. l-Sesamin showed no inhibitory activity at 30 microM.

Anti-inflammatory and analgesic activities of the ethanolic extracts from Zanthoxylum riedelianum (Rutaceae) leaves and stem bark

“…Sesamin has displayed, among other activities, a role of actions in the inflammatory process by inhibiting primary activation pathways, such as mitogen-activated protein kinase and nuclear factor kappa B (Hou et al 2003;Jeng et al 2005). In addition, it was not able to inhibit PGE 2 in-vitro (Lee et al 2005). Hinokinin, a dibenzylbutirolactone lignan, has been reported to display anti-inflammatory, peripheral analgesic (da Silva et al 2005), trypanocidal (Saraiva et al 2007), cytotoxicity against P-388 and HT-29 tumour cell lines (Lin et al 2004) and anti-human hepatitis B virus-anti-HBeAg activity (Huang et al 2003).…”

Chemical Constituents and an Antineuroinflammatory Lignan, Savinin from the Roots of Acanthopanax henryi

“…Various pharmacological activities of lignans, including compound 3 (savinin), have been reported. These activities include cytotoxic effects against human cancer cell lines [36], CYP3A4 inactivation [37], antisevere acute respiratory syndrome associated coronavirus (SARS-CoV) activity [38], inhibition of PGE 2 production in rat peritoneal macrophages [39], antiestrogenic [40], insecticidal [41], and inhibition of TNF- α production in RAW264.7 macrophage cells [42]; however, this is the first finding on the antineuroinflammatory effects of compound 3 (savinin) to the best of our knowledge.…”

An Ethnopharmacological, Phytochemical and Pharmacological Review on Lignans from Mexican Bursera spp.

“…It has been tested for different biological activities, such as cytotoxicity against several tumor cell lines [ 36 , 64 , 65 , 66 ]. Savinin ( 2 ) was shown to have an anti-inflammatory activity in several assays [ 40 , 44 , 67 , 68 , 69 ], but also interesting antinociceptive, anxiolytic, and antioxidant activities [ 70 , 71 ].…”