Lignans: Chemical and Biological Properties

Cunha, Wilson Roberto; Silva, Márcio Luís Andrade e; Veneziani, Rodrigo Cássio Sola; Ambrósio, Sérgio Ricardo; Bastos, Jairo Kenupp

doi:10.5772/28471

Cited by 3 publications

(1 citation statement)

References 68 publications

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“…The DHFF unit is an important skeletal structure in various biologically and pharmaceutically active organic molecules and it is very useful for organic transformations to potential bioactive molecules [28]. As the isolation or the preparation of different types of FF lignans is difficult, the analysis of the relationship between the FF ring, its conjugates, and the established clinical activities has not been done yet [20,29,30,31].…”

Section: Resultsmentioning

confidence: 99%

Extracts from Cell Suspension Cultures of Strawberry (Fragaria x ananassa Duch): Cytotoxic Effects on Human Cancer Cells

et al. 2019

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Natural compounds are emerging as agents for the treatment of malignant diseases. We previously showed that extracts from in vitro cell suspension cultures of strawberry reduced murine melanoma cell proliferation, as shown for fruit extracts. In this work, chromatographic, mass spectrometric, and spectrophotometric analyses were carried out to identify the bioactive compound exerting the detected cytotoxic activity. Moreover, aiming to confirm the anti-proliferative activity of the extracts against both paediatric and adult human tumors, cytotoxic experiments were performed on neuroblastoma, colon, and cervix carcinoma cell lines. Extracts from in vitro cell suspension cultures of strawberry induced a statistically significant reduction of cell growth in all the tumor cell lines tested. Interestingly, human fibroblasts from healthy donors were not subjected to this cytotoxic effect, highlighting the importance of further preclinical investigations. The accurate mass measurement, fragmentation patterns, and characteristic mass spectra and mass losses, together with the differences in chromatographic retention times and absorbance spectra, led us to hypothesize that the compound acting as an anti-proliferative agent could be a novel acetal dihydrofurofuran derivative (C8H10O3, molecular mass 154.0630 amu)

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Section: Resultsmentioning

confidence: 99%

Extracts from Cell Suspension Cultures of Strawberry (Fragaria x ananassa Duch): Cytotoxic Effects on Human Cancer Cells

et al. 2019

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1-(Phenylsulfonyl)-3-oxabicyclo[3.1.0]hexan-2-one as a Building Block in Organic Synthesis

2018

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The transformation of the readily available phenylsulfonyl lactone building block to structurally diverse molecular scaffolds is described. Depicted structures are accessed in one to three steps, and their overall yields are high. The rigidity of the starting building block greatly directs the stereoselectivity of the transformations, and newly generated stereogenic centers including the quaternary carbon centers are formed with high stereoselectivity generally superior to dr > 95:1.

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An Ethnopharmacological, Phytochemical and Pharmacological Review on Lignans from Mexican Bursera spp.

2018

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The genus Bursera belongs to the family Burseraceae and has been used in traditional Mexican medicine for treating various pathophysiological disorders. The most representative phytochemicals isolated from this genus are terpenoids and lignans. Lignans are phenolic metabolites known for their antioxidant, apoptotic, anti-cancer, anti-inflammatory, anti-bacterial, anti-viral, anti-fungal, and anti-protozoal properties. Though the genus includes more than 100 species, we have attempted to summarize the biological activities of the 34 lignans isolated from selected Mexican Bursera plants.

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Lignans: Chemical and Biological Properties

Cited by 3 publications

References 68 publications

Extracts from Cell Suspension Cultures of Strawberry (Fragaria x ananassa Duch): Cytotoxic Effects on Human Cancer Cells

Extracts from Cell Suspension Cultures of Strawberry (Fragaria x ananassa Duch): Cytotoxic Effects on Human Cancer Cells

1-(Phenylsulfonyl)-3-oxabicyclo[3.1.0]hexan-2-one as a Building Block in Organic Synthesis

An Ethnopharmacological, Phytochemical and Pharmacological Review on Lignans from Mexican Bursera spp.

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