Lignans and Triterpenes from the Root of &lt;i&gt;Pseuderanthemum carruthersii&lt;/i&gt; var. &lt;i&gt;atropurpureum&lt;/i&gt;

Vo, Thi Nga; Nguyen, Phi Linh; Tuong, Lam Truong; Pratt, Lawrence M.; Vo, Phung Nguyen; Nguyen, Kim Phi Phung; Nguyen, Ngoc Suong

doi:10.1248/cpb.c12-00222

Cited by 27 publications

(5 citation statements)

References 19 publications

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“…To review the relative configurations of 8-OH-type furofuran lignans, 1-hydroxypinoresinol ( 10 ), pseuderesinol ( 11 ), , (+)-1-hydroxy-6-epipinoresinol ( 12 ), (+)-6-epifraxiresinol 4′,4″-di- O -methyl ether ( 13 ), (1 R *,2 R *,5 R *,6 R *)-2,6-bisphenyl-1-hydroxy-3,7-dioxabicyclo[3.3.0]octane ( 14 ), (+)-gmelinol ( 15 ), 1-hydroxyfurofuran ( 16 ), neogmelinol ( 17 ), (+)-1-hydroxy-2,6-bisepipinoresinol ( 18 ), and dipsalignan A ( 19 ) (Figure ) were selected as model compounds. The configuration of 14 was determined from its single-crystal X-ray crystallography .…”

Section: Resultsmentioning

confidence: 99%

“…The configuration of 14 was determined from its single-crystal X-ray crystallography . Since their 7,9′:7′,9-diepoxy moiety also possesses a cis -fused configuration, − these compounds can be classified into four groups according to the orientations of the two aromatic rings: (IV) 7-H/8-OH trans , 7′-H/8′-H trans ( 10 , 11 ); (V) 7-H/8-OH trans , 7′-H/8′-H cis ( 12 – 15 ); (VI) 7-H/8-OH cis , 7′-H/8′-H cis ( 16 ); and (VII) 7-H/8-OH cis , 7′-H/8′-H trans ( 17 – 19 ).…”

Section: Resultsmentioning

confidence: 99%

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An Efficient Method for Determining the Relative Configuration of Furofuran Lignans by ¹H NMR Spectroscopy

et al. 2018

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An efficient H NMR spectroscopic approach for determining the relative configurations of lignans with a 7,9':7',9-diepoxy moiety has been established. Using the chemical shift differences of H-9 and H-9' (Δδ and Δδ), the configurations of 8-H and 8-OH furofuran lignans can be rapidly and conveniently determined. The rule is applicable for data acquired in DMSO- d, methanol- d, or CDCl. Notably, the rule should be applied carefully when the C-2 or C-6 substituent of the aromatic rings may alter the dominant conformers of the furofuran moiety.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

An Efficient Method for Determining the Relative Configuration of Furofuran Lignans by ¹H NMR Spectroscopy

et al. 2018

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“…Magnolin also prevented the start and development of the "vicious cycle" between cancer metastases and the bone microenvironment by preventing PTHrP synthesis in osteoclastic bone resorption breast cancer cells [96]. When used against the cancer cell line MCF-7, Vo et al observed that magnolin showed only moderate cytotoxic effects [57].…”

Section: Magnolin Against Various Cancers 241 Breast Cancermentioning

confidence: 99%

Anticancer Potentials of the Lignan Magnolin: A Systematic Review

et al. 2023

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Magnolin is a naturally occurring, multi-bioactive lignan molecule with inherent anticancer effects. This study aims to summarize the botanical origins and anticancer properties of magnolin. For this, a recent (as of March 2023) literature review was conducted using various academic search engines, including PubMed, Springer Link, Wiley Online, Web of Science, Science Direct, and Google Scholar. All the currently available information about this phytochemical and its role in various cancer types has been gathered and investigated. Magnolin is a compound found in many different plants. It has been demonstrated to have anticancer activity in numerous experimental models by inhibiting the cell cycle (G1 and G2/M phase); inducing apoptosis; and causing antiinvasion, antimetastasis, and antiproliferative effects via the modulation of several pathways. In conclusion, magnolin showed robust anticancer activity against many cancer cell lines by altering several cancer signaling pathways in various non- and pre-clinical experimental models, making it a promising plant-derived chemotherapeutic option for further clinical research.

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“…The compound isolated from A. tatarinowii was identified as eudesmin (Vo et al, 2012) (Fig. 1, Table 1).…”

Section: Identification Of Eudesmin Isolated From Acorus Tatarinowiimentioning

confidence: 99%

Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats

Líu

Song

Da-guang

et al. 2015

Phytotherapy Research

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This paper was designed to investigate anticonvulsant and sedative effects of eudesmin isolated from Acorus tatarinowii. The eudesmin (5, 10, and 20 mg/kg) was administered intraperitoneally (i.p.). The maximal electroshock test (MES) and pentylenetertrazole (PTZ)-induced seizures in male mice were used to evaluate anticonvulsant activities of eudesmin, and sedative effects of eudesmin were evaluated by pentobarbital sodium-induced sleeping time (PST) and locomotor activity in mice. Finally, the mechanisms of eudesmin were investigated by determining contents of glutamic acid (Glu) and gamma-aminobutyric acid (GABA) in epileptic mice, and expressions of glutamate decarboxylase 65 (GAD65), GABAA , Bcl-2, and caspase-3 in the brain of chronic epileptic rats. Results of MES and PTZ tests revealed that eudesmin possesses significant anticonvulsant effects, and the PST and locomotor activity tests demonstrated that eudesmin has significant sedative effects. Furthermore, our study revealed that after treatment with eudesmin, GABA contents increased, whereas Glu contents decreased, and ratio of Glu/GABA decreased. Our results also indicated that expressions of GAD65, GABAA, and Bcl-2 were up-regulated by treating with eudesmin, whereas the caspase-3 obviously was down-regulated. In conclusion, eudesmin has significant anticonvulsant and sedative effects, and the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.

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Lignans and Triterpenes from the Root of <i>Pseuderanthemum carruthersii</i> var. <i>atropurpureum</i>

Cited by 27 publications

References 19 publications

An Efficient Method for Determining the Relative Configuration of Furofuran Lignans by ¹H NMR Spectroscopy

An Efficient Method for Determining the Relative Configuration of Furofuran Lignans by ¹H NMR Spectroscopy

Anticancer Potentials of the Lignan Magnolin: A Systematic Review

Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats

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Lignans and Triterpenes from the Root of <i>Pseuderanthemum carruthersii</i> var. <i>atropurpureum</i>

Cited by 27 publications

References 19 publications

An Efficient Method for Determining the Relative Configuration of Furofuran Lignans by 1H NMR Spectroscopy

An Efficient Method for Determining the Relative Configuration of Furofuran Lignans by 1H NMR Spectroscopy

Anticancer Potentials of the Lignan Magnolin: A Systematic Review

Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats

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An Efficient Method for Determining the Relative Configuration of Furofuran Lignans by ¹H NMR Spectroscopy

An Efficient Method for Determining the Relative Configuration of Furofuran Lignans by ¹H NMR Spectroscopy