Lignans and Other Constituents of<i>Centaurea sphaerocephala</i>ssp.<i>polyacantha</i>

Bastos, Margarida; Kijjoa, Anake; Cardoso, José Manuel Mota; Gutiérrez, Alicia Beatriz; Herz, Werner

doi:10.1055/s-2006-960994

Cited by 21 publications

(6 citation statements)

References 6 publications

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“…C. sphaerocephala, locally named 'fiordaliso delle spiagge', is a perennial grassy plant with scattered leaves, 50 cm tall, that blooms from June to September. In previous investigations C. sphaerocephala has been shown to contain various polyacetylenic compounds, 13 lignans 14 and sesquiterpene lactones, 9 while for C. calcitrapa sesquiterpene lactones and lignans were described. [15][16][17] Volatile components obtained from acetone extracts of flowers, leaves, stems and flowerhead buds of C. calcitrapa have also been described previously.…”

Section: Introductionmentioning

confidence: 95%

Volatile components ofCentaurea calcitrapa L. andCentaurea sphaerocephala L. ssp.sphaerocephala, two Asteraceae growing wild in Sicily

et al. 2006

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Section: Introductionmentioning

confidence: 95%

Volatile components ofCentaurea calcitrapa L. andCentaurea sphaerocephala L. ssp.sphaerocephala, two Asteraceae growing wild in Sicily

et al. 2006

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“…given the interest of Centaurea pharmacology and phytochemistry and within the context of the study of Centaurea species growing in Algeria Zater et al , Kolli et al 2012, Bicha et al 2011, Bentamene et al 2010, Medjroubi et al 2005, we have taken interest in to study Centaurea sphaerocephala l. Previous studies on this species and/or its subspecies led to the isolation of flavonoid aglycones (Bentamene et al 2008), flavonoid glucosides (Bentamene et al 2010), sesquiterpene lactones (Bruno et al 1994(Bruno et al , geppert et al 1983), lignans, sesquilignans and a dithienylacetylene (Bastos et al 1990). The composition of the essential oil of this species was also reported (Senatore et al 2006).…”

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant, DNA-damaged protection and antiproliferative activities of ethyl acetate and n-butanol extracts of Centaurea sphaerocephalaL.

Lahneche

Boucheham

Özen

et al. 2019

An. Acad. Bras. Ciênc.

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This study aimed to evaluate the in vitro antiproliferative and inhibition of oxidative DNAdamage activities of n-butanol (n-BuOH) extract of Centaurea sphaerocephala. The in vitro antioxidant activity of the ethyl acetate (etOAc) and the n-BuOH extracts of this plant were also assayed. To investigate the antioxidant potential, extracts were tested for their capacity to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH · ) and to inhibit lipid peroxidation using the TBARs method. The contents of total phenolics and flavonoids were measured. Additionally, antiproliferative activity and DNA-damage inhibition of the n-BuOH extract was determined using XCelligence RTCA instrument and photolyzing 46966 plasmid, respectively. The results exhibited that the scavenging abilities of the etOAc extract were better than the n-BuOH extract with an IC 50 = 11.59 µg/ml and 16.67 µg/ml for both extracts, respectively. The phenolic and flavonoid contents were found higher in the n-BuOH and etOAc extracts. Furthermore, our results showed that n-BuOH extract exhibited a remarkable inhibition of lipid peroxidation with an IC 50 of 340.94±7.49 μg/mL and had an antiproliferative effect against Hela cells. Extracts of C. sphaerocephala showed antioxidant activity on scavenging DPPH · . In addition, the n-BuOH extract inhibited the lipid peroxidation and exhibited an antiproliferative effect against HeLa cells line (human cervix carcinoma).

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“…Arctiin and ATG were identified as the major compounds in Centaurea sphaerocephala ssp. Polyacantha and were also found in the AL used in this study [28, 29]. …”

Section: Introductionmentioning

confidence: 64%

Inhibitory Effect of Arctigenin from Fructus Arctii Extract on Melanin Synthesis via Repression of Tyrosinase Expression

Park

Song²,

Jung³

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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To identify the active compound arctigenin in Fructus Arctii (dried seed of medicinal plant Arctium lappa) and to elucidate the inhibitory mechanism in melanogenesis, we analyzed melanin content and tyrosinase activity on B16BL6 murine melanoma and melan-A cell cultures. Water extracts of Fructus Arctii were shown to inhibit tyrosinase activity in vitro and melanin content in α-melanocyte stimulating hormone-stimulated cells to similar levels as the well-known kojic acid and arbutin, respectively. The active compound arctigenin of Fructus Arctii displayed little or no cytotoxicity at all concentrations examined and decreased the relative melanin content and tyrosinase activity in a dose-dependent manner. Melanogenic inhibitory activity was also identified in vivo with zebrafish embryo. To determine the mechanism of inhibition, the effects of arctigenin on tyrosinase gene expression and tyrosinase promoter activity were examined. Also in addition, in the signaling cascade, arctigenin dose dependently decreased the cAMP level and promoted the phosphorylation of extracellular signal-regulated kinase. This result suggests that arctigenin downregulates cAMP and the tyrosinase enzyme through its gene promoter and subsequently upregulates extracellular signal-regulated kinase activity by increasing phosphorylation in the melanogenesis signaling pathway, which leads to a lower melanin content.

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Lignans and Other Constituents ofCentaurea sphaerocephalassp.polyacantha

Abstract: Extraction of the aerial parts of CENTAUREA SPHAEROCEPHALA L. ssp. POLYACANTHA (Willd.) Dostal furnished the lignans (-)-matairesinol, (-)-arctigenin, and (-)-arctiin, two sesquilignans lappaol A and a stereo- or structural isomer of lappaol A, and a new dithienylacetylene.

Cited by 21 publications

References 6 publications

Volatile components ofCentaurea calcitrapa L. andCentaurea sphaerocephala L. ssp.sphaerocephala, two Asteraceae growing wild in Sicily

Volatile components ofCentaurea calcitrapa L. andCentaurea sphaerocephala L. ssp.sphaerocephala, two Asteraceae growing wild in Sicily

In vitro antioxidant, DNA-damaged protection and antiproliferative activities of ethyl acetate and n-butanol extracts of Centaurea sphaerocephalaL.

Inhibitory Effect of Arctigenin from Fructus Arctii Extract on Melanin Synthesis via Repression of Tyrosinase Expression

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