Lignans and indole alkaloids from the seeds of <i>Centaurea vlachorum</i> Hartvig (Asteraceae), growing wild in Albania and their biological activity

Hodaj, Entela; Tsiftsoglou, Olga; Abazi, Sokol; Hadjipavlou‐Litina, Dimitra; Lazari, Diamanto

doi:10.1080/14786419.2016.1226823

Cited by 28 publications

(16 citation statements)

References 28 publications

(28 reference statements)

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“…New drug development for glioma should focus on substances with MW less than 600 in order to pass the intact BBB. 9 Herewith, we investigated the anti-tumor effects of moschamine, which was isolated from the seeds of C. vlachorum as previously reported 10 in glioblastoma cell lines.…”

Section: Moschamine Inhibits Proliferation Of Glioblastoma Cells Via mentioning

confidence: 99%

Moschamine inhibits proliferation of glioblastoma cells via cell cycle arrest and apoptosis

et al. 2017

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Glioblastoma is the most common and most malignant primary brain tumor with a median survival of 15 months. Moschamine is an indole alkaloid that has a serotoninergic and cyclooxygenase inhibitory effect. In this study, we sought to determine whether moschamine could exert cytotoxic and cytostatic effects on glioma cells in vitro. Moschamine was tested for toxicity in zebrafish. We investigated the effect of moschamine on U251MG and T98G glioblastoma cell lines. Viability and proliferation of the cells were examined with trypan blue exclusion assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and the xCELLigence system. Apoptosis (annexin-propidium iodide), cell cycle, and CD24/CD44/CD56/CD15 expression were tested with flow cytometry. Treatment with moschamine significantly reduced cell viability in both cell lines tested. Induction of cell death and cell cycle arrest was confirmed with flow cytometry in both cell lines. After treatment with moschamine, there was a dose-dependent decrease in CD24 and CD44 expression, whereas there was no change in CD56 and CD15 expression in T98G cell line. The zebrafish mortality on the fifth post-fertilization day was zero even for 1 mM of moschamine concentration. The treatment of glioblastoma cell lines with moschamine may represent a novel strategy for targeting glioblastoma.

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Section: Moschamine Inhibits Proliferation Of Glioblastoma Cells Via mentioning

confidence: 99%

Moschamine inhibits proliferation of glioblastoma cells via cell cycle arrest and apoptosis

et al. 2017

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“…Aerial parts -Antibacterial activity [77] -There was no any activity of plant EO against 10 examined bacteria C. vlachorum Hartvig Seeds -Antioxidant activity [80] -Inhibitor activity [80] -DPPH assay revealed good antioxidant properties for all isolated components (N-p-coumaroyl-serotonin, matairesinol and moschamine) except in case of arctiin.…”

Section: Sibthorpii Halácsymentioning

confidence: 99%

“…Alb, Grc Aerial parts -EOs [79] Hydrodistillation GC-MS Caryophyllene-oxide (11.9 - Seeds -Lignans and alcaloids [80] No data 1 H NMR spectroscopy No data -The first report about 2 lignans (matairesinol and arctiin) and 2 alcaloids (N-pcoumaroyl-serotonin and moschamine) in seeds of this plant has been made.…”

Section: Vlachorum Hartvigmentioning

confidence: 99%

Balkans’ Asteraceae Species as a Source of Biologically Active Compounds for the Pharmaceutical and Food Industry

Kostić

Janaćković

Kolašinac

et al. 2020

Chemistry & Biodiversity

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Herbal drugs are a useful source of different bioactive compounds. Asteraceae species, as the most widespread vascular plants can be used both as food and as medicine due to the great diversity of recorded chemical componentsdifferent phenolic compounds, terpenes, carotenoids, vitamins, alkaloids, etc. The Balkan Peninsula is characterized by great diversity of plants from Asteraceae family, including presence of rare and endemic species. In this review, results of the survey of chemical composition and biological activity, mainly focusing on antioxidant, antimicrobial and anticancer effects of selected Balkans' Asteraceae species were provided. In addition, information on edible plants from Asteraceae family is presented, due to growing interest for the so-called "healthy diet" and possible application of Balkans' Asteraceae species as food of high nutritional value or as a source of functional food ingredients.

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“…Studies on antioxidant activity on a range of lignans have been done using AAPH, but only in some cases the major oxidation products have been characterized [51,52,53,54,55,56]. Upon radical scavenging, the lignans form phenoxyl radicals with their radical delocalized over the phenolic ring, followed by radical coupling at either the ipso - or meta -position, or through the para phenoxyl radical.…”

Section: Non-metal-mediated Oxidationsmentioning

confidence: 99%

Oxidative Transformations of Lignans

Runeberg¹,

Brusentsev²,

Rendon³

et al. 2019

Molecules

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Numerous oxidative transformations of lignan structures have been reported in the literature. In this paper we present an overview on the current findings in the field. The focus is put on transformations targeting a specific structure, a specific reaction, or an interconversion of the lignan skeleton. Oxidative transformations related to biosynthesis, antioxidant measurements, and total syntheses are mostly excluded. Non-metal mediated as well as metal mediated oxidations are reported, and mechanisms based on hydrogen abstractions, epoxidations, hydroxylations, and radical reactions are discussed for the transformation and interconversion of lignan structures. Enzymatic oxidations, photooxidation, and electrochemical oxidations are also briefly reported.

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Lignans and indole alkaloids from the seeds of Centaurea vlachorum Hartvig (Asteraceae), growing wild in Albania and their biological activity

Cited by 28 publications

References 28 publications

Moschamine inhibits proliferation of glioblastoma cells via cell cycle arrest and apoptosis

Moschamine inhibits proliferation of glioblastoma cells via cell cycle arrest and apoptosis

Balkans’ Asteraceae Species as a Source of Biologically Active Compounds for the Pharmaceutical and Food Industry

Oxidative Transformations of Lignans

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