Lignans

Álvarez-Caballero, Juan Manuel; Coy-Barrera, Ericsson

doi:10.1016/b978-0-12-819096-8.00050-1

Cited by 3 publications

(1 citation statement)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and Gram-negative (Pseudomonas aeruginosa, Escherichia coli, etc.) bacteria at low temperatures is also demonstrated by the presence of methoxy and phenolic hydroxyl groups in the lignans [72,73].…”

Section: Non-flavonoidsmentioning

confidence: 95%

Antimicrobial Activities of Natural Bioactive Polyphenols

Mandal,

Domb

2024

Pharmaceutics

View full text Add to dashboard Cite

Secondary metabolites, polyphenols, are widespread in the entire kingdom of plants. They contain one or more hydroxyl groups that have a variety of biological functions in the natural environment. These uses include polyphenols in food, beauty products, dietary supplements, and medicinal products and have grown rapidly during the past 20 years. Antimicrobial polyphenols are described together with their sources, classes, and subclasses. Polyphenols are found in different sources, such as dark chocolate, olive oil, red wine, almonds, cashews, walnuts, berries, green tea, apples, artichokes, mushrooms, etc. Examples of benefits are antiallergic, antioxidant, anticancer agents, anti-inflammatory, antihypertensive, and antimicrobe properties. From these sources, different classes of polyphenols are helpful for the growth of internal functional systems of the human body, providing healthy fats, vitamins, and minerals, lowering the risk of cardiovascular diseases, improving brain health, and rebooting our cellular microbiome health by mitochondrial uncoupling. Among the various health benefits of polyphenols (curcumin, naringenin, quercetin, catechin, etc.) primarily different antimicrobial activities are discussed along with possible future applications. For polyphenols and antimicrobial agents to be proven safe, adverse health impacts must be substantiated by reliable scientific research as well as in vitro and in vivo clinical data. Future research may be influenced by this evaluation.

show abstract

Section: Non-flavonoidsmentioning

confidence: 95%

Antimicrobial Activities of Natural Bioactive Polyphenols

Mandal,

Domb

2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

The therapeutic effect of Loranthus parasiticus lignan derivatives on collagen-induced arthritis in rats through the SHBG/NFκB pathway

Bai,

Zhang,

Liu

et al. 2024

Inflammopharmacol

View full text Add to dashboard Cite

Lignan-rich beans, nuts, and various seeds are the main protective food with antioxidative and hormones modulating activity. However, although the role of lignans in mediating hormone-dependent cancers, and cardiovascular disease is well characterized, the function of lignans in anti-arthritic activity and its actual mechanisms remain unknown. A set of three new lignan derivatives named (-)-nortrachelogenin, trachelogenin, and matairesinol were extracted from Loranthus parasiticus. After the establishment of collagen-induced arthritis (CIA) model by intradermal injection of collagen, rats were treated with the mixed three new lignan derivatives ((-)-nortrachelogenin: 37%; trachelogenin: 27%; matairesinol: 25.7%) at a concentration of 50 mg/kg and 100 mg/kg, or methotrexate of 0.3 mg/kg. The mixed lignan derivatives signi cantly attenuated the immune responses in the joints of CIA rats, resulting in decreased levels of pro-in ammatory cytokine (IL-6, TNF-α) and boosted free androgen in serum compared to the CIA model.The results of molecular docking via the AutoDock Vina showed that lignan derivative (-)nortrachelogenin is the most effective compound for binding to SHBG, then leading to inhibiting the activity of NFκB in LPS-stimulated macrophages. In this study, (-)-nortrachelogenin was identi ed as the previously unrecognized anti-in ammatory activity of natural lignan new derivative, and its molecular mechanism is related to the regulating NFκB/SHBG pathway. Our ndings suggest further application of sex hormone-like compounds in treating rheumatoid arthritis and potential clinical applications of (-)nortrachelogenin.

show abstract

The therapeutic effect of Loranthus parasiticus lignans derivatives on collagen-induced arthritis in rats through SHBG/NFκB pathway

Bai

Zhang

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

Lignan-rich beans, nuts, and various seeds are the main protective food with antioxidative and hormones modulating activity. However, although the role of lignans in mediating hormone-dependent cancers, and cardiovascular disease is well characterized, the function of lignans in anti-arthritic activity and its actual mechanisms remain unknown. A set of three new lignan derivatives named (-)-nortrachelogenin, trachelogenin, and matairesinol were extracted from Loranthus parasiticus. After the establishment of collagen-induced arthritis (CIA) model by intradermal injection of collagen, rats were treated with the mixed three new lignan derivatives ((-)-nortrachelogenin: 37%; trachelogenin: 27%; matairesinol: 25.7%) at a concentration of 50 mg/kg and 100 mg/kg, or methotrexate of 0.3 mg/kg. The mixed lignan derivatives significantly attenuated the immune responses in the joints of CIA rats, resulting in decreased levels of pro-inflammatory cytokine (IL-6, TNF-α) and boosted free androgen in serum compared to the CIA model. The results of molecular docking via the AutoDock Vina showed that lignan derivative (-)-nortrachelogenin is the most effective compound for binding to SHBG, then leading to inhibiting the activity of NFκB in LPS-stimulated macrophages. In this study, (-)-nortrachelogenin was identified as the previously unrecognized anti-inflammatory activity of natural lignan new derivative, and its molecular mechanism is related to the regulating NFκB/SHBG pathway. Our findings suggest further application of sex hormone-like compounds in treating rheumatoid arthritis and potential clinical applications of (-)-nortrachelogenin.

show abstract

Lignans

Cited by 3 publications

References 132 publications

Antimicrobial Activities of Natural Bioactive Polyphenols

Antimicrobial Activities of Natural Bioactive Polyphenols

The therapeutic effect of Loranthus parasiticus lignan derivatives on collagen-induced arthritis in rats through the SHBG/NFκB pathway

The therapeutic effect of Loranthus parasiticus lignans derivatives on collagen-induced arthritis in rats through SHBG/NFκB pathway

Contact Info

Product

Resources

About