Lightning 12: A new player in the field of pulmonary percutaneous mechanical thrombectomy

Araszkiewicz, Aleksander; Sławek-Szmyt, Sylwia; Jankiewicz, Stanisław; Grygier, Marek; Lesiak, Maciej

doi:10.33963/kp.a2022.0181

Cited by 5 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, a new generation of Lightning 12F system (Penumbra Inc, Alameda, CA, USA) was introduced that includes new innovative mechanisms to prevent blood loss, efficiently regulate aspiration and enable aspiration of larger clots. 12 , 34 What is more, the next-generation highly torqueable Lightning Flash 16 system (Penumbra Inc, Alameda, CA, USA) with dual clot detection algorithms and no necessity for separator use has just been released in the USA. 35 The results of the ongoing STRIKE-PE study will show whether Lightning technology ultimately improves short- and long-term clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Catheter-directed mechanical aspiration thrombectomy in a real-world pulmonary embolism population: a multicenter registry

Sławek-Szmyt

Stępniewski

Kurzyna³

et al. 2023

European Heart Journal: Acute Cardiovascular Care

Self Cite

View full text Add to dashboard Cite

Background High- (HR) and intermediate-high risk (IHR) pulmonary embolisms (PEs) are related to high early mortality and long-term sequelae. We aimed to describe clinical outcomes and adverse events in IHR and HR PE treated with catheter-directed mechanical thrombectomy (CDMT) in a real-world population. Methods This study is a multicenter, prospective registry enrolling 110 PE patients treated with CDMT between 2019 and 2022. The CDMT was performed using the 8F Indigo (Penumbra, Alameda, US) system bilaterally in pulmonary arteries (PAs). The primary safety endpoints included device or PE-related death during the 48-hour after CDMT, procedure-related major bleeding, or other major adverse events. Secondary safety outcomes were all-cause mortality during hospitalization or the follow-up. The primary efficacy outcomes were the reduction of PA pressures and change in the RV-to-left ventricular (RV/L) ratio assessed in the imaging 24-48 hours after the CDMT. Results 71.8% of patients had IHR PE and 28.2% HR PE. 11.8% of patients had a failure and 34.5% had contraindications to thrombolysis, and 2.7% had polytrauma. There was 0.9% intraprocedural death related to RV failure and 5.5% deaths within the first 48 hours. CDMT was complicated by major bleeding in 1.8, pulmonary artery injury in 1.8%, and ischemic stroke in 0.9%. Immediate hemodynamic improvements included a 10.4 ± 7.8 mmHg (19.7%) drop in systolic PAP (p < 0.0001), a 6.1 ± 4.2 mmHg (18.8%) drop in mean PAP, and 0.48 ± 0.4 (36%) drop in RV/LV ratio (p < 0.0001). Conclusions These observational findings suggest that CDMT may improve hemodynamics with an acceptable safety profile in patients with IHR and HR PE.

show abstract

Section: Discussionmentioning

confidence: 99%

Catheter-directed mechanical aspiration thrombectomy in a real-world pulmonary embolism population: a multicenter registry

Sławek-Szmyt

Stępniewski

Kurzyna³

et al. 2023

European Heart Journal: Acute Cardiovascular Care

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, a new Lightning 12, intelligent computer-assisted vacuum aspiration system (Penumbra, Alameda, CA, US) has been introduced, which is thought to more efficiently regulate aspiration, and reduce blood loss in comparison to the previous generation device (Indigo CAT8) [4][5][6]. This study aims to evaluate the outcomes of the Lightning 12 aspiration system.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the 12F catheter's flexibility advantageously improves maneuvers within tortuous vessels and enlarged right heart ventricles. A larger diameter, improved catheter design, and an intelligent control unit allow for the more adequate removal of thrombi from both pulmonary arteries without increasing periprocedural blood loss compared to the previous generation of the device (Indigo CAT8 device) [5,[9][10][11]. Using larger-bore catheters and sheaths seems feasible and effective.…”

mentioning

confidence: 99%

Lightning 12 — an intelligent computer-assisted vacuum aspiration thrombectomy system in the treatment of pulmonary embolism: An initial experience

Araszkiewicz,

Sławek-Szmyt,

Jankiewicz

et al. 2024

Pol Heart J

View full text Add to dashboard Cite

show abstract

“…It may favor a more aggressive approach, including faster utilization of catheter-directed therapies despite the fact the patient is at "intermediate" risk and looks hemodynamically stable [3]. In this context, contemporary large-bore aspiration catheters seem to be a breakthrough in the treatment of patients with PE [4].…”

mentioning

confidence: 99%

To intervene or not to intervene? Catheter-directed mechanical thrombectomy in intermediate-high risk pulmonary embolism with fragmentation of a saddle thrombus

et al. 2023

View full text Add to dashboard Cite

Lightning 12: A new player in the field of pulmonary percutaneous mechanical thrombectomy

Cited by 5 publications

References 4 publications

Catheter-directed mechanical aspiration thrombectomy in a real-world pulmonary embolism population: a multicenter registry

Catheter-directed mechanical aspiration thrombectomy in a real-world pulmonary embolism population: a multicenter registry

Lightning 12 — an intelligent computer-assisted vacuum aspiration thrombectomy system in the treatment of pulmonary embolism: An initial experience

To intervene or not to intervene? Catheter-directed mechanical thrombectomy in intermediate-high risk pulmonary embolism with fragmentation of a saddle thrombus

Contact Info

Product

Resources

About