Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy

Liu, Lin; Wang, Ruibo; Wang, Chunran; Wang, Jinze; Chen, Li; Cheng, Jianjun

doi:10.1039/c7bm01114h

Cited by 32 publications

(12 citation statements)

References 28 publications

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“…Additionally, pullulan acts as a natural ligand for the asialoglyco protein receptor (ASGPR) [224], which is often overexpressed by HCC cells. In 2018, Liu and co-workers [225] reported a light-responsive porphyrin-dextranbased polymeric DOX conjugate to control DOX release through ROS-cleavable linker combined with PDT. In 2009, Khdair and co-workers [226] constructed aerosol OT (AOT)-alginate nanoparticles for the co-delivery of DOX and methylene blue (a photo activated dye by 665 nm wavelength) in drug-resistant NCI/ADR-RES cells (a multidrug-resistant cell line in ovarian cancer).…”

Section: Application Of Polymers In Pdtmentioning

confidence: 99%

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

et al. 2022

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This review provides a summary of recent progress in the development of different nano-platforms for the efficient synergistic effect between photodynamic therapy and chemotherapy. In particular, this review focuses on various methods in which photosensitizers and chemotherapeutic agents are co-delivered to the targeted tumor site. In many cases, the photosensitizers act as drug carriers, but this review, also covers different types of appropriate nanocarriers that aid in the delivery of photosensitizers to the tumor site. These nanocarriers include transition metal, silica and graphene-based materials, liposomes, dendrimers, polymers, metal–organic frameworks, nano emulsions, and biologically derived nanocarriers. Many studies have demonstrated various benefits from using these nanocarriers including enhanced water solubility, stability, longer circulation times, and higher accumulation of therapeutic agents/photosensitizers at tumor sites. This review also describes novel approaches from different research groups that utilize various targeting strategies to increase treatment efficacy through simultaneous photodynamic therapy and chemotherapy.

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Section: Application Of Polymers In Pdtmentioning

confidence: 99%

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

et al. 2022

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“…As a commonly used therapy strategy for cancer treatments, chemotherapy helps to kill cancer cells effectively, but simultaneously causes strong toxicity to normal cells, tissues, and organs . Therefore, it is of great importance to reduce the side effects of chemotherapy through controllable release of chemotherapy drugs . Recently, the strategy of combining chemotherapy with PTT has significantly enhanced cancer therapeutic efficiency and reduced the side effects caused by rapid release of chemotherapy drugs .…”

Section: Applications Of Graphitic Nanocapsulesmentioning

confidence: 99%

Recent Advances in Multifunctional Graphitic Nanocapsules for Raman Detection, Imaging, and Therapy

Liu

Zhu

et al. 2019

Small Methods

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To date, a variety of graphitic nanomaterial-based applications have facilitated the development of biomedical applications, such as carbon quantumdot-based biosensors and imaging systems, [14][15][16][17] graphene oxide-based biosensors [18][19][20][21][22] and drug delivery systems, [20,[23][24][25] and carbon nanotube-based therapy applications. [26][27][28][29] Compared with other widely used nanomaterials, graphitic nanomaterials show superior fluorescence quenching performance, larger Raman scattering cross-sections than conventional organic Raman tags, [30] and better biocompatibility. [31] With the goal of broadening their applications, great attention has been focused on integrating graphitic materials with other inorganic nanomaterials such as noble metals [32,33] and magnetic nanomaterials. [34,35] Such graphitic nanomaterial-metal hybrid nanostructures make full use of the excellent properties of both graphitic and metal nanomaterials, and have much wider application prospect in bioanalysis. [36] However, most of the reported hybrid nanostructures, in which metal nanomaterials are exposed on the surface of graphitic nanomaterials encounter difficulty in maintaining their morphologies and stable properties under harsh conditions, such as long-term laser irradiation or strong acidic environments, which might cause inaccurate bioanalytical results and even potential biotoxicity. [37][38][39] Therefore, it is critical to prepare novel graphitic nanomaterials with superstability to meet the demands of reliable bioanalysis and biomedicine.As a type of novel graphite nanomaterial with a core-shell structure, superior physicochemical properties, good biocompatibility, superior stability, and controllable size, graphitic nanocapsules have been extensively applied in biosensing, [40,41] bioimaging, [42,43] drug delivery, [43,44] and cancer treatment. [45] Benefiting from the large surface area of the outside graphitic shell, graphitic nanocapsules supply superior nanoplatforms for drugs and targeting-molecule loading, which further broadens their biomedical applications. [42,44,46] In addition, the graphitic shell of graphitic nanocapsules possesses several unique Raman scattering bands and can act as a Raman signal tag or stable internal standard (IS) for accurate surface enhanced Raman scattering (SERS) analysis. [46,47] Particularly, the 2D band (≈2650 cm −1 ) within the cellular Raman-silent region is beneficial to avoiding the interference signals from Benefiting from their unique physicochemical properties, graphitic nanocapsules with a core-shell structure have attracted tremendous interest in bioanalysis and biomedicine recently. Using rational design, various types of graphitic nanocapsules with controllable properties are prepared to meet the demands of different biomedical applications. Graphitic nanocapsules exhibit excellent stability and superior capacity for loading nucleic acids, proteins, small molecules, and drugs due to the large specific surface area of their graphitic shells. Moreover, usin...

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“…18 Many powerful nanoformulations have been developed by sophisticated design and fabrication, which involves combining many functional molecules to satisfy all the demands. 19–22 However, to our knowledge, the principal characteristics of the nanoformulations approved by the Food and Drug Administration (FDA), such as those of liposomal doxorubicin, albumin-based nanoparticles and paclitaxel-loaded micelles, are simple and have unambiguous structure. 23,24 Despite the remarkable advances achieved in the recent few decades, there are no multifunctional nanotechnology therapeutic products clinically approved by the FDA for cancer therapy so far.…”

Section: Introductionmentioning

confidence: 99%

Effect of the disulfide bond and polyethylene glycol on the degradation and biophysicochemical properties of polyurethane micelles

et al. 2022

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Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy

Cited by 32 publications

References 28 publications

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

Recent Advances in Multifunctional Graphitic Nanocapsules for Raman Detection, Imaging, and Therapy

Effect of the disulfide bond and polyethylene glycol on the degradation and biophysicochemical properties of polyurethane micelles

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