Light-triggered NO release from a nanofibrous non-woven

Carbon monoxide – physiology, detection and controlled release

“…For the generation of NORMAs, novel biscarboxamide rutheniumnitrosyl complexes {RuNO} 6 have been synthesised. 197,198 For a photoCORMA, Mn 2 (CO) 10 (CORM-1) was used. 199,200 The metal complexes were non-covalently embedded into the polymer matrices via miniemulsion technique 201 or electrospinning.…”

“…The NORMAs and CORMAs are important for the development of safe NO and CO delivering devices for therapeutic purposes; toxic metabolites after gas release are retained in the biocompatible polymer matrix. 197–200 …”

Unconventional Non‐Aqueous Emulsions for the Encapsulation of a Phototriggerable NO‐Donor Complex in Polymer Nanoparticles

“…This is the case for instance for some ruthenium nitrosyl complexes that are currently investigated as improved phototriggerable NO donor systems . As an example, for an NO donor with low solubility, the ruthenium nitrosyl complex [(mib)Ru(NO)Cl] (mib = N , N ′‐(1,2‐phenylene)bis(1‐methyl‐1 H ‐imidazole‐2‐carboxamide)) has already been presented ( Figure ) . This metal complex is insoluble in water but can be made accessible to water if incorporated into a polymer matrix as electrospun non‐woven.…”

“…However, encapsulation of insoluble substances remains a difficult challenge in colloid science. Ruthenium complexes with the ability to release NO molecules upon light activation were already physically entrapped in various structures, including hydrogels, microparticles, and polymer nanofibers; but not yet within nanoparticles.…”

“…We focused our attention on the solvent hexafluoroisopropanol (HFIP) because it was found to be a good solvent for the [(mib)Ru(NO)Cl] complex, which could be therefore successfully entrapped in poly( l ‐lactide‐ co ‐ d / l ‐lactide) nanofibers by electrospinning . HFIP is an unconventional but interesting solvent in organic chemistry due to its low nucleophilicity and high ionizing power .…”