Light-triggered carbon monoxide delivery with Al-MCM-41-based nanoparticles bearing a designed manganese carbonyl complex

Gonzales, Margarita A.; Han, Howard; Moyes, Amie J; Radinos, Achilles; Hobbs, Adrian J.; Coombs, Neil; Oliver, Scott R. J.; Mascharak, Pradip K.

doi:10.1039/c3tb21309a

Cited by 47 publications

(71 citation statements)

References 32 publications

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“…These systems show significant absorptions in the visible, with the sulfur-containing ligand 34 giving the most desirable outcome. Notably, there was a marked difference between complexes bearing halide ligands and those featuring other donors: fac-Mn(34)(CO) 3 Br as an absorbption maximum of 535 nm which is shifted to 435 nm in fac-[Mn (34) 72 where broadband illumination leads to the anticipated CO release.…”

Section: Visible Light Photocormsmentioning

confidence: 99%

PhotoCORMs: CO release moves into the visible

Wright

2016

Dalton Trans.

114

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The potential of carbon monoxide to act as a therapeutic agent is now well-established. Controlled delivery of CO is best achieved using 'CORMs': molecules which release known amounts of carbon monoxide in response to a stimulus. Metal carbonyl complexes will release CO if irradiated with ultraviolet light, but it is only in the past five years that development of true 'photoCORMs' has been explored. Recent exciting developments in this area now show that design of photoCORMs operating well into the visible region is achievable. In this Perspective, we examine the growth of photoCORMs from their origins in the photophysics of metal carbonyls to the latest visible-light agents.

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Section: Visible Light Photocormsmentioning

confidence: 99%

PhotoCORMs: CO release moves into the visible

Wright

2016

Dalton Trans.

114

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“…However, there have been few reports on the effects of CO released into cells and tissues by light irradiation of the photoactive CORMs. [36][37][38] To adapt the reactivities of photoactive CORMs to cellular environments,i ti se ssential to design scaffolds with improved biocompatibility such as proteins because several proteins have great potential to deliver CORMs. [39][40][41][42][43] In this work, we developed ap hotoactive CO-releasing protein based on ferritin (Fr), an iron storage protein.…”

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confidence: 99%

A Photoactive Carbon‐Monoxide‐Releasing Protein Cage for Dose‐Regulated Delivery in Living Cells

et al. 2015

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Protein cages can serve as bioinorganic molecular templates for functionalizing metal compounds to regulate cellular signaling. We succeeded in developing a photoactive CO-releasing system by constructing a composite of ferritin (Fr) containing manganese-carbonyl complexes. When Arg52 adjacent to Cys48 of Fr is replaced with Cys, the Fr mutant stabilizes the retention of 48 Mn-carbonyl moieties, which can release the CO ligands under light irradiation, although wild-type Fr retains very few Mn moieties. The amount of released CO is regulated by the extent of irradiation. This could reveal an optimized dose for cooperatively activating the nuclear factor κB (NF-κB) in mammalian cells and the tumor necrosis factor α (TNF-α). These results suggest that construction of a CO-releasing protein cage will advance of research in CO biology.

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“…Tissue-targeting materials. Unlike the micelle-and NP-based carriers of CORMs, dendrimers, 59 copolymers, 60 and porous materials [61][62][63] have been utilized as tissue-targeting scaffolds. These scaffolds are expected to accumulate passively and selectively in tumor tissues as a result of the enhanced permeability and retention effect.…”

Section: Synthetic Polymer Materialsmentioning

confidence: 99%

“…These scaffolds are expected to accumulate passively and selectively in tumor tissues as a result of the enhanced permeability and retention effect. 60,61 Smith et al modified dendritic scaffolds with a [MnBr(bpy)-(CO) 3 ] moiety to obtain CO-releasing metallodendrimers (Fig. 7a).…”

Section: Synthetic Polymer Materialsmentioning

confidence: 99%

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Design of biomaterials for intracellular delivery of carbon monoxide

2015

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Carbon monoxide (CO) is recognized as one of the most important gas signaling molecules involved in governing various therapeutic responses. Intracellular generation of CO is spatiotemporally controlled by catalytic reactions of heme oxygenases (HOs). Thus, the ability to control intracellular CO delivery with modulation of the CO-release rate in specific amounts and locations is expected to improve our fundamental understanding of the functions of CO and the development of clinical applications. For this purpose, CO-releasing molecules (CORMs) have been developed and investigated in vitro and in vivo. Most CORMs are based on transition metal carbonyl complexes. Recently, various biomaterials consisting of metal carbonyls with biomacromolecular scaffolds have been reported to improve the properties of bare metal carbonyls. In this mini-review, current progress in CO delivery, recent strategies for the development of CORMs, and future directions in this field are discussed.

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Light-triggered carbon monoxide delivery with Al-MCM-41-based nanoparticles bearing a designed manganese carbonyl complex

Cited by 47 publications

References 32 publications

PhotoCORMs: CO release moves into the visible

PhotoCORMs: CO release moves into the visible

A Photoactive Carbon‐Monoxide‐Releasing Protein Cage for Dose‐Regulated Delivery in Living Cells

Design of biomaterials for intracellular delivery of carbon monoxide

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