Light-Triggered Anti-Infective Surfaces

Craig, Rebecca; McCoy, Colin

doi:10.1007/978-3-319-57494-3_10

Cited by 2 publications

(3 citation statements)

References 147 publications

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“…A stimulus of light can be delivered easily using a remote source; it induces a fast response and avoids the risk of unwanted side effects . Light is more attractive among the external stimuli, because its wavelength and intensity (dose) can be precisely controlled as required by medical devices . Surprisingly, currently only a few publications have reported the development of bioresponsive materials capable of switching between bactericidal and bacteria-releasing functions in response to UV or visible light. − A common strategy to synthesize a light-responsive bioresponsive material is to attach a photoswitchable molecule onto a solid substrate.…”

Section: Dual-function Bioresponsive Materialsmentioning

confidence: 99%

Switchable Dual-Function and Bioresponsive Materials to Control Bacterial Infections

Ghasemlou¹,

Daver²,

Ivanova

et al. 2019

ACS Appl. Mater. Interfaces

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The colonization of undesired bacteria on the surface of devices used in biomedical and clinical applications has become a persistent problem. Different types of single-function (cell resistance or bactericidal) bioresponsive materials have been developed to cope with this problem. Even though these materials meet the basic requirements of many biomedical and clinical applications, dual-function (cell resistance and biocidal) bioresponsive materials with superior design and function could be better suited for these applications. The past few years have witnessed the emergence of a new class of dual-function materials that can reversibly switch between cell-resistance and biocidal functions in response to external stimuli. These materials are finding increased applications in biomedical devices, tissue engineering, and drug-delivery systems. This review highlights the recent advances in design, structure, and fabrication of dualfunction bioresponsive materials and discusses translational challenges and future prospects for research involving these materials.

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Section: Dual-function Bioresponsive Materialsmentioning

confidence: 99%

Switchable Dual-Function and Bioresponsive Materials to Control Bacterial Infections

Ghasemlou¹,

Daver²,

Ivanova

et al. 2019

ACS Appl. Mater. Interfaces

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“…Immobilization of PEGSiD in appropriate solid supports to fabricate 'active' solid phases constitute a step further towards developing novel antibacterial surfaces as well as new applications in various fields, such as in water disinfection and optosensing and therapeutic approaches [11,12]. In general, immobilized photosenzitizers in batch and continuous regimes and under reuse have been demonstrated to maintain their antibacterial properties against gram-negative and gram-positive bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…In general, immobilized photosenzitizers in batch and continuous regimes and under reuse have been demonstrated to maintain their antibacterial properties against gram-negative and gram-positive bacteria. The photodynamic properties of immobilized photosenzitizers are retained for longer periods of time as they become more resistant to photobleaching than in their free form [12,13]. However, most reported SiDs applications are restricted to solution assays [14] and mainly photovoltaic uses employ 'as obtained' SiDs in a silicon dioxide matrix [15].…”

Section: Introductionmentioning

confidence: 99%

Staphylococcus aureus biofilm eradication by the synergistic effect exerted by PEG-coated silicon dots immobilized in silica films and light irradiation

et al. 2020

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Immobilization of PEG-covered silicon dots, PEGSiDs, on glass substrates was performed following a simple strategy involving particle embedding by a sol-gel process forming a silica film on glass slides. The obtained films, denoted as fSiO x -PEGSiD, constitute a water-wettable, strongly supported, photoluminescent glass coating. The films showed high capacity for photosensitizing singlet oxygen (1O2) in the UVA when immersed in water. Staphylococcus aureus colonies formed on fSiO x -PEGSiDs modified glasses revealed the inhibition of bacterial adhesion and bacterial growth leading to the formation of loosely-packed and smaller S. aureus colonies. Upon 350 nm light irradiation of the biofilmed fSiO x -PEGSiDs -modified glasses, S. aureus growth was inhibited and bacteria killed reducing the number of living bacteria by three orders of magnitude. Eradication of attached bacteria was achieved by the synergistic effect exerted by a less adherent fSiO x -PEGSiDs surface that inhibits biofilm formation and the ability of the surface to photosensitize 1O2 to kill bacteria.

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Light-Triggered Anti-Infective Surfaces

Cited by 2 publications

References 147 publications

Switchable Dual-Function and Bioresponsive Materials to Control Bacterial Infections

Switchable Dual-Function and Bioresponsive Materials to Control Bacterial Infections

Staphylococcus aureus biofilm eradication by the synergistic effect exerted by PEG-coated silicon dots immobilized in silica films and light irradiation

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