Light transport in tissue: Accurate expressions for one‐dimensional fluence rate and escape function based upon Monte Carlo simulation

Gardner, Craig; Jacques, Steven L.; Welch, A.J.

doi:10.1002/(sici)1096-9101(1996)18:2<129::aid-lsm2>3.3.co;2-k

Cited by 19 publications

(21 citation statements)

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“…Studies have been widely performed to analyze optical propagation in various media. Farrell et al have developed an instrument to estimate penetration depth from the spatially resolved diffuse reflectance [23]. Takatani and Graham developed a two-layer photon diffusion model that was shown to provide a good description of diffuse reflectance from intestinal tissue [24].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Diffuse Reflectance in Multi-layered Tissue for High Intensity Laser Therapy

Lee¹,

Youn²

2013

Journal of the Optical Society of Korea

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Pain is one of the quite common symptoms in clinics and many treatment methods have been applied to relieve pain. Among the treatments, high-intensity light therapy for pain has been introduced, but this therapy has not been fully supported by confirmed efficacy due to the absence of quantitative assessments and treatment feedback data in real time. In this study, the evaluation of light distribution in tissue was performed with current high-intensity light sources quantitatively using light-tissue interaction simulations. The diffuse reflectance in tissue was generated using Monte Carlo simulation that traces photons as they undergo multiple scattering and absorption within each tissue layer (skin, fat, and muscle) and within multi-layered tissue. The results showed that the highest diffuse reflectance and the deepest penetration of tissue were achieved at λ =830 nm when compared with other wavelengths like λ =650 nm, 980 nm and 1064 nm.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Diffuse Reflectance in Multi-layered Tissue for High Intensity Laser Therapy

Lee¹,

Youn²

2013

Journal of the Optical Society of Korea

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“…We have modified the original form ( [6,7] to be Eq. (4) because the term ( ) The objective function for minimization is defined as the least square difference between analytical fit of fluence rate, fit φ , and the MC simulation, MC φ , for a range of tissue optical properties μ a between 0.01 to 1 cm −1 and μ s ' between 2 and 40 cm −1 and beam radius between 0.5 and 8 cm.…”

Section: Analytical Expression and Fitting Algorithmmentioning

confidence: 99%

“…Literature search reveals only analytical expression for broad beams, when the lateral dimension is much larger than the mean-free path [6,7]. The light distribution of broad beams in tissue is only dependent on the two dimensional tissue optical properties ( .…”

Section: Introductionmentioning

confidence: 99%

Analytic function for predicting light fluence rate of circular fields on a semi-infinite turbid medium

Ong¹,

Zhu²

2016

Opt. Express

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Accurate determination of in-vivo light fluence rate is critical for preclinical and clinical studies involving photodynamic therapy (PDT). The light fluence distribution in tissue depends on both the tissue optical properties and the incident field size. This study compares the longitudinal light fluence distribution inside biological tissue in the central axis of circular uniform light field with different radii for a range of in-vivo tissue optical properties (absorption coefficients (µ a ) between 0.01 and 1 cm −1 and reduced scattering coefficients (µ s ') between 2 and 40 cm −1 ). This was done using Monte-Carlo simulations for a semi-infinite turbid medium in an air-tissue interface. The end goal is to develop simple analytical expressions that would fit the results from the Monte Carlo simulation for circular beams with different radii. A 6-parameter model ( can be used to fit MC simulation. Each of these parameters (b, C 2 , C 3 , λ 1 , λ 2 , and λ 3 ) is expressed as a function of tissue optical properties and beam radius. These results can then be compared against the existing expressions in the literature for broad beam for analysis in both accuracy and applicable range. The analytical function can be used as rapid guide in PDT to calculate in vivo light fluence distribution for known tissue optical properties.

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“…Under broad beam irradiance, the light distribution in scattering tissues is described with two exponentials as [12] )]…”

Section: Problem Formulationmentioning

confidence: 99%

Analysis of Thermal Damage in a Laser-Irradiated Based on the Non-Fourier Model

Liu¹,

Cheng²,

Wang³

2014

IJET

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Light transport in tissue: Accurate expressions for one‐dimensional fluence rate and escape function based upon Monte Carlo simulation

Cited by 19 publications

References 0 publications

Evaluation of Diffuse Reflectance in Multi-layered Tissue for High Intensity Laser Therapy

Evaluation of Diffuse Reflectance in Multi-layered Tissue for High Intensity Laser Therapy

Analytic function for predicting light fluence rate of circular fields on a semi-infinite turbid medium

Analysis of Thermal Damage in a Laser-Irradiated Based on the Non-Fourier Model

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