Light-to-Moderate Alcohol Intake Is Associated With Enhanced Insulin Sensitivity

Facchini, Francesco; Chen, Y-D. Ida; Reaven, Gerald M.

doi:10.2337/diacare.17.2.115

Cited by 284 publications

(173 citation statements)

References 0 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…Light-to-moderate alcohol consumption is well known to enhance insulin sensitivity. [35][36][37] Furthermore, in our study population, a considerably lower level of serum -carotene compared with other carotenoids, such as -cryptoxanthin or -carotene, might be one of the causes for the discrepancies. The cause of the discrepant results between male and female subjects in the present study should be clarified in further studies.…”

Section: Malementioning

confidence: 70%

The Homeostasis Model Assessment-insulin Resistance Index Is Inversely Associated with Serum Carotenoids in Non-diabetic Subjects

Sugiura

Nakamura

Ikoma

et al. 2006

Journal of Epidemiology

View full text Add to dashboard Cite

BACKGROUND Carotenoids may reduce the risk for diabetes mellitus, but little is known about the association of insulin resistance with serum carotenoids in non-diabetic subjects. This study aimed to investigate whether the homeostasis model assessment-insulin resistance (HOMA-IR) index would be lower in the presence of high serum carotenoid concentrations in non-diabetic subjects. METHODS A total of 812 subjects (256 males and 556 females) who had received health examinations in 2003 participated in the study. The associations of the serum-carotenoid concentrations and HOMA-IR were evaluated cross-sectionally. The multivariate-adjusted geometric means of HOMA-IR by the tertiles of the serum carotenoid concentration were calculated after adjusting for age, body mass index, systolic blood pressure, total cholesterol, triacylglycerols, current tobacco use, regular alcohol intake, exercise habits and total energy intake. Associations among high HOMA-IR (3.0+ mU×mmol/L 2 ) across tertiles of serum carotenoid concentration were assessed by tests for logistic regression analysis. RESULTS In male subjects, the multivariate adjusted geometric mean of HOMA-IR was inversely associated with the serum β -cryptoxanthin concentrations. In female subjects, an inverse association of the serum carotenoid concentration and HOMA-IR was observed in lycopene, β -cryptoxanthin, and zeaxanthin. The confounding factor-adjusted odds ratios (OR) for high HOMA-IR on the highest tertiles of serum α -carotene, β -carotene, β -cryptoxanthin, and zeaxanthin were 0.18 [95% confidence interval (CI): 0.06-0.52], 0.22 (95% CI: 0.07-0.67), 0.34 (95% CI: 0.12-0.96), and 0.30 (95% CI: 0.11-0.79), respectively, in male subjects. On the other hand, in female subjects, the adjusted OR for high HOMA-IR on the highest tertiles of serum lycopene and β -cryptoxanthin were 0.39 (95% CI: 0.21-0.73) and 0.51 (95% CI: 0.28-0.95), respectively. CONCLUSIONS The serum antioxidant carotenoids were inversely associated with HOMA-estimated insulin resistance in non-diabetic subjects.

show abstract

Section: Malementioning

confidence: 70%

The Homeostasis Model Assessment-insulin Resistance Index Is Inversely Associated with Serum Carotenoids in Non-diabetic Subjects

Sugiura

Nakamura

Ikoma

et al. 2006

Journal of Epidemiology

View full text Add to dashboard Cite

show abstract

“…to the observation that alcohol intake reduces insulin resistance (70), which is strongly related to obesity (71) and may be related to a higher risk for colorectal cancer (38,72,73). Thus, among persons with a higher body mass index, the adverse effect of alcohol on risk for colorectal cancer might be offset by the beneficial effects of alcohol on insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Alcohol Intake and Colorectal Cancer: A Pooled Analysis of 8 Cohort Studies

Cho

Smith‐Warner²,

Ritz³

et al. 2004

Ann Intern Med

391

225

View full text Add to dashboard Cite

“…Light to moderate intake is associated with improved insulin sensitivity (Facchini et al, 1994;Kiechl et al, 1996;Lazarus et al, 1997;Davies et al, 2002) and with a lower risk of diabetes (Howard et al, 2004). Because obesity is a risk factor for renal cell cancer (Calle and Kaaks, 2004), and diabetics are at higher risk than those without diabetes (Wideroff et al, 1997;Lindblad et al, 1999), it is possible that improved insulin sensitivity lowers renal cell cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Alcoholic beverages and risk of renal cell cancer

et al. 2007

View full text Add to dashboard Cite

Using a mailed questionnaire, we investigated the risk of renal cell cancer in relation to different types of alcoholic beverages, and to total ethanol in a large population-based case -control study among Swedish adults, including 855 cases and 1204 controls. Compared to non-drinkers, a total ethanol intake of 4620 g month À1 was significantly related to a decreased risk of renal cell cancer (odds ratio (OR) 0.6, 95% confidence interval (CI) 0.4 -0.9; P-value for trend ¼ 0.03). The risk decreased 30 -40% with drinking more than two glasses per week of red wine (OR 0.6, 95% CI 0.4 -0.9), white wine (OR 0.7, 95% CI 0.4 -1.0), or strong beer (OR 0.6, 95% CI 0.4 -1.0); there was a clear linear trend of decreasing risk with increasing consumption of these beverages (P-values for trends o0.05).

show abstract

Light-to-Moderate Alcohol Intake Is Associated With Enhanced Insulin Sensitivity

Cited by 284 publications

References 0 publications

The Homeostasis Model Assessment-insulin Resistance Index Is Inversely Associated with Serum Carotenoids in Non-diabetic Subjects

The Homeostasis Model Assessment-insulin Resistance Index Is Inversely Associated with Serum Carotenoids in Non-diabetic Subjects

Alcohol Intake and Colorectal Cancer: A Pooled Analysis of 8 Cohort Studies

Alcoholic beverages and risk of renal cell cancer

Contact Info

Product

Resources

About