Light therapy for mood disorders

Bais, Babette; Hoogendijk, Witte J.G.; Berg, Mijke P. Lambregtse–van den

doi:10.1016/b978-0-12-819973-2.00004-6

Cited by 5 publications

(8 citation statements)

References 129 publications

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“…Many zeitgebers known to influence the circadian system, such as light, food, melatonin, and exercise, have been used for this purpose [59]. Light therapy is a widely used adjunct therapy in sleep-wake rhythm and psychiatric disorders (such as depression and bipolar disorder [60]), but also in neurodegenerative disorders (such as Alzheimer's disease and Parkinson's disease [61]). Time-restricted eating, in which food consumption is limited to a window of 8 to 12 hours per day (without caloric restriction), improves glucose regulation, triglyceride levels, blood pressure, and various quality of life measures [62].…”

Section: Targeting the Clockmentioning

confidence: 99%

Foundations of circadian medicine

et al. 2022

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The circadian clock is an evolutionarily highly conserved endogenous timing program that structures physiology and behavior according to the time of day. Disruption of circadian rhythms is associated with many common pathologies. The emerging field of circadian medicine aims to exploit the mechanisms of circadian physiology and clock–disease interaction for clinical diagnosis, treatment, and prevention. In this Essay, we outline the principle approaches of circadian medicine, highlight the development of the field in selected areas, and point out open questions and challenges. Circadian medicine has unambiguous health benefits over standard care but is rarely utilized. It is time for clock biology to become an integrated part of translational research.

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Section: Targeting the Clockmentioning

confidence: 99%

Foundations of circadian medicine

et al. 2022

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“…109 Light therapy, for example, is widely used in psychiatric and neurological diseases. [110][111][112] Bright light in AD has been shown to improve sleep efficacy during the night, decrease napping during the day, improve cognition, and reduce depression. [113][114][115] Moreover, light exposure during evening hours is effective in inducing more solid sleep during the night and more stable rest/activity rhythms.…”

Section: Circadian Medicine Approachesmentioning

confidence: 99%

“…Targeting the clock using zeitgebers such as light, food, and exercise can be used for this purpose 109 . Light therapy, for example, is widely used in psychiatric and neurological diseases 110–112 . Bright light in AD has been shown to improve sleep efficacy during the night, decrease napping during the day, improve cognition, and reduce depression 113–115 .…”

Section: Introductionmentioning

confidence: 99%

Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease

et al. 2023

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Dysfunction of circadian and sleep rhythms is an early feature of many neurodegenerative diseases. Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in cognitive and psychiatric disturbances. Although it is largely unclear whether dysfunctions in sleep and circadian rhythms contribute to the etiology of AD or are a consequence of the disease, there is evidence that these conditions are involved in a complex self‐reinforcing bidirectional relationship. According to the recent studies, dysregulation of the circadian clock already occurs during the asymptomatic stage of the disease and could promote neurodegeneration. Thus, restoration of sleep and circadian rhythms in preclinical AD may represent an opportunity for early intervention to slow the disease course.

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“…Regardless, light therapy appears to be a promising form of therapy with minimal, if any, adverse effects (Simons et al, 2016). Light therapy has also been used to treat Alzheimer's disease, Parkinson's disease, mood disorders, and cancer-related fatigue, highlighting its versatility in treatment applications (van Maanen et al, 2016;Videnovic et al, 2017;Bais et al, 2021;Hung et al, 2021;Kolberg et al, 2021). Future studies should thoroughly investigate the effectiveness of light therapy in a variety of patient groups and settings.…”

Section: Chronopharmacology and Chronotherapeuticsmentioning

confidence: 99%

Circadian Synchrony: Sleep, Nutrition, and Physical Activity

Healy

Morris

Liu

2021

Front. Netw. Physiol.

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The circadian clock in mammals regulates the sleep/wake cycle and many associated behavioral and physiological processes. The cellular clock mechanism involves a transcriptional negative feedback loop that gives rise to circadian rhythms in gene expression with an approximately 24-h periodicity. To maintain system robustness, clocks throughout the body must be synchronized and their functions coordinated. In mammals, the master clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN is entrained to the light/dark cycle through photic signal transduction and subsequent induction of core clock gene expression. The SCN in turn relays the time-of-day information to clocks in peripheral tissues. While the SCN is highly responsive to photic cues, peripheral clocks are more sensitive to non-photic resetting cues such as nutrients, body temperature, and neuroendocrine hormones. For example, feeding/fasting and physical activity can entrain peripheral clocks through signaling pathways and subsequent regulation of core clock genes and proteins. As such, timing of food intake and physical activity matters. In an ideal world, the sleep/wake and feeding/fasting cycles are synchronized to the light/dark cycle. However, asynchronous environmental cues, such as those experienced by shift workers and frequent travelers, often lead to misalignment between the master and peripheral clocks. Emerging evidence suggests that the resulting circadian disruption is associated with various diseases and chronic conditions that cause further circadian desynchrony and accelerate disease progression. In this review, we discuss how sleep, nutrition, and physical activity synchronize circadian clocks and how chronomedicine may offer novel strategies for disease intervention.

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Light therapy for mood disorders

Cited by 5 publications

References 129 publications

Foundations of circadian medicine

Foundations of circadian medicine

Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's disease

Circadian Synchrony: Sleep, Nutrition, and Physical Activity

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