Abstract:Microscale mechanical properties of the extracellular matrix (ECM) and dynamic cell-ECM interactions play an important role in physiological processes and disease. However, it remains a challenge for current mechanical characterization methods to combine quantitative 3D imaging of ECM mechanics with cellular-scale resolution and dynamic monitoring of cell mediated changes to pericellular viscoelasticity. Here, we present light-sheet photonic force optical coherence elastography (LS-pfOCE) to address these chal… Show more
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