Light Scattering Study on the Effect of Polymer Composition on the Structural Properties of PEO–PPO–PEO Micelles

Nolan, Stuart L.; Phillips, Ronald J.; Cotts, Patricia M.; Dungan, Stephanie R.

doi:10.1006/jcis.1997.4918

Cited by 116 publications

(149 citation statements)

References 41 publications

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“…This orderliness agrees with Perreura's result in the experiment [61]. Nolan et al have found that the aggregation number of linear triblock copolymers appeared to increase with the increasing molecular weight while keeping the PEO/PPO ratio constant [62]. However, here the branched block polyether has a smaller aggregation number than the linear polyether.…”

Section: Resultssupporting

confidence: 89%

Comparison of aggregation behaviors between branched and linear block polyethers: MesoDyn simulation study

Gong

Shi

et al. 2010

Colloid Polym Sci

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Section: Resultssupporting

confidence: 89%

Comparison of aggregation behaviors between branched and linear block polyethers: MesoDyn simulation study

Gong

Shi

et al. 2010

Colloid Polym Sci

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“…Eq. [8] where the CMC is in wt% of sample PBA-b-PAA, M BA is the molar mass of a monomer BA, X BA/AA is the mass ratio of BA over AA in a hypothetic monodisperse diblock sample considered in this calculation, v is the molecular volume of a BA monomer, N a is the Avogadro number, n is the polymerization number of the PBA block There is no adjustable parameter since interfacial tension PBA/H2O has been measured at 20 mN/m by sessile drop shape analysis. Figure 16 presents the calculated CMC values vs the molar mass of the PBA block for a series of PBA-b-PAA samples with X BA/AA of 0.25.…”

Section: Interfacial Tension As a Control Parameter For Reversibilitymentioning

confidence: 99%

Chemical analysis and aqueous solution properties of charged amphiphilic block copolymers PBA-b-PAA synthesized by MADIX®

Jacquin¹,

Muller

Talingting-Pabalan³

et al. 2007

Journal of Colloid and Interface Science

164

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We have linked the structural and dynamic properties in aqueous solution of amphiphilic charged diblock copolymers poly(butyl acrylate)-b-poly(acrylic acid), PBA-b-PAA, synthesized by controlled radical polymerization, with the physico-chemical characteristics of the samples. Despite product imperfections, the samples self-assemble in melt and aqueous solutions as predicted by monodisperse microphase separation theory. However, the PBA core are abnormally large; the swelling of PBA cores is not due to AA (the Flory parameter PBA/PAA , determined at 0.25, means strong segregation), but to h-PBA homopolymers (content determined by Liquid Chromatography at the Point of Exclusion and Adsorption Transition LC-PEAT). Beside the dominant population of micelles detected by scattering experiments, capillary electrophoresis CE analysis permitted detection of two other populations, one of h-PAA, and the other of free PBA-b-PAA chains, that have very short PBA blocks and never self-assemble. Despite the presence of these free unimers, the self-assembly in solution was found out of equilibrium: the aggregation state is history dependant and no unimer exchange between micelles occurs over months (time-evolution SANS). The high PBA/water interfacial tension, measured at 20 mN/m, prohibits unimer exchange between micelles. PBA-b-PAA solution systems are neither at thermal equilibrium nor completely frozen systems: internal fractionation of individual aggregates can occur.

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“…The approximate micelle aggregation number (N agg ) can be calculated from the ratio of the average molecular weight of the micelle to the molecular weight of the block copolymer [14,15,16]. Dynamic Light Scattering experiments indicated that the average molecular weight of the micelle is ∼ 4.6×10 4 Dalton.…”

Section: Fluorescent Dye Encapsulation and Release From Polymeric Micmentioning

confidence: 99%

Polymeric micelle-based bioassay with femtomolar sensitivity

Mouffouk

Chishti

Jin

et al. 2008

Analytical Biochemistry

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Target specific polymeric micelles loaded with fluorescence dye molecules in their hydrophobic cores were made from block co-polymer of poly(carprolactones) 23 -b-poly(ethylene oxide) 45 (PCL23-b-PEO45). It was found that the micelles are stable against pH changes from 2 to 12 and temperature variation up to 65 °C. The dye molecules can be released to the solution upon exposing the micelles to organic solvents or ultrasound. A rapid and highly sensitive immunoassay based on the above micelles was developed, and the assay can detect specific target proteins in femtomolar range from complex biological samples such as serum mimics and cell lysate. For example, less than 0.15 unit/ml of ovarian cancer specific antigen 125 (CA125), equivalent to 7.5 × 10 -15 M, can be reliably detected in solution. We also demonstrated the assay can detect a cell surface biomarker (SAAE-4) from a single human embryonic stem (hES) cell.

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Light Scattering Study on the Effect of Polymer Composition on the Structural Properties of PEO–PPO–PEO Micelles

Cited by 116 publications

References 41 publications

Comparison of aggregation behaviors between branched and linear block polyethers: MesoDyn simulation study

Comparison of aggregation behaviors between branched and linear block polyethers: MesoDyn simulation study

Chemical analysis and aqueous solution properties of charged amphiphilic block copolymers PBA-b-PAA synthesized by MADIX®

Polymeric micelle-based bioassay with femtomolar sensitivity

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