Light-responsive nanomedicine for biophotonic imaging and targeted therapy

Son, Jihwan; Yi, Gawon; Yoo, Jin‐Hong; Park, Changhee; Koo, Heebeom; Choi, Hak

doi:10.1016/j.addr.2018.10.002

Cited by 108 publications

(75 citation statements)

References 96 publications

(181 reference statements)

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“…If the intensity of input radiation is moderate, like in the case of sunlight exposure, the heat produced can be dissipated by biological tissues safely, without causing significant local temperature increase [32]. On the contrary, upon locally controlled and intense light stimulation, the heat generation can be exploited for producing acoustic signals for diagnostic as in PAI or even induce a local hyperthermia and kill cancer cells as in PTT [33]. (2) Antioxidant and free radical scavenging activity.…”

Section: Introductionmentioning

confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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Bioinspired nanomaterials are ideal components for nanomedicine, by virtue of their expected biocompatibility or even complete lack of toxicity. Natural and artificial melanin-based nanoparticles (MNP), including polydopamine nanoparticles (PDA NP), excel for their extraordinary combination of additional optical, electronic, chemical, photophysical, and photochemical properties. Thanks to these features, melanin plays an important multifunctional role in the design of new platforms for nanomedicine where this material works not only as a mechanical support or scaffold, but as an active component for imaging, even multimodal, and simple or synergistic therapy. The number of examples of bio-applications of MNP increased dramatically in the last decade. Here, we review the most recent ones, focusing on the multiplicity of functions that melanin performs in theranostics platforms with increasing complexity. For the sake of clarity, we start analyzing briefly the main properties of melanin and its derivative as well as main natural sources and synthetic methods, moving to imaging application from mono-modal (fluorescence, photoacoustic, and magnetic resonance) to multi-modal, and then to mono-therapy (drug delivery, anti-oxidant, photothermal, and photodynamic), and finally to theranostics and synergistic therapies, including gene- and immuno- in combination to photothermal and photodynamic. Nanomedicine aims not only at the treatment of diseases, but also to their prevention, and melanin in nature performs a protective action, in the form of nanopigment, against UV-Vis radiations and oxidants. With these functions being at the border between nanomedicine and cosmetics nanotechnology, recently examples of applications of artificial MNP in cosmetics are increasing, paving the road to the birth of the new science of nanocosmetics. In the last part of this review, we summarize and discuss these important recent results that establish evidence of the interconnection between nanomedicine and cosmetics nanotechnology.

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Section: Introductionmentioning

confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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“…This treatment strategy could also inhibit the osteoclastic RANKL and Sclerostin expression from tumor cells, thus further attenuating downstream osteoclastogenesis. Notably, the shapes of these nanoparticles can change their photoresponsive properties, and NIR absorbing nanorods and nanocages have been preferred for in vivo applications 4 . The heat released by these nanoparticles under NIR light irradiation would efficiently kill cancer cells via photothermal ablation.…”

Section: Discussionmentioning

confidence: 99%

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Wan¹,

Zhang²,

Lv³

et al. 2020

Theranostics

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Recently, the rapid development of biomaterials has induced great interest in the precisely targeted treatment of bone-related diseases, including bone cancers, infections, and inflammation. Realizing noninvasive therapeutic effects, as well as improving bone tissue regeneration, is essential for the success of bone‑related disease therapies. In recent years, researchers have focused on the development of stimuli-responsive strategies to treat bone-related diseases and to realize bone regeneration. Among the various external stimuli for targeted therapy, near infrared (NIR) light has attracted considerable interests due to its high tissue penetration capacity, minimal damage toward normal tissues, and easy remote control properties. The main objective of this systematic review was to reveal the current applications of NIR light-assisted phototherapy for bone-related disease treatment and bone tissue regeneration. Database collection was completed by June 1, 2020, and a total of 81 relevant studies were finally included. We outlined the various therapeutic applications of photothermal, photodynamic and photobiomodulation effects under NIR light irradiation for bone‑related disease treatment and bone regeneration, based on the retrieved literatures. In addition, the advantages and promising applications of NIR light-responsive drug delivery systems for spatiotemporal-controlled therapy were summarized. These findings have revealed that NIR light-assisted phototherapy plays an important role in bone-related disease treatment and bone tissue regeneration, with significant promise for further biomedical and clinical applications.

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“…According to their pore size, which enables the different membrane processes (pervaporation, reverse osmosis, gas separation, nanofiltration, ultrafiltration, microfiltration, distillation) and component separation (gas, salts, sugars, proteins, bacteria, emulsions, colloids), porous membranes can be distinguished in nonporous (ρ < 0.1 nm), microporous (0.1 < ρ < 2 nm), mesoporous (2 < ρ < 50 nm), and macroporous (ρ > 50 nm) membranes . Separation in sieving processes is strongly dependent on feed components and membrane pore sizes and applied stimuli …”

Section: Membrane Processesmentioning

confidence: 99%

“…High performance magnetic‐responsive membranes are generally filled with magnetic‐active nanoparticles of metals, metal oxides, or ferromagnetic materials. Their main application is the active delivery and release of drugs loaded in small polymer drug delivery systems such as liposomes, niosomes, and vesicles …”

Section: Introductionmentioning

confidence: 99%

Light‐Responsive Polymer Membranes

Pantuso

Filpo

Nicoletta

2019

Advanced Optical Materials

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Stimuli‐responsive polymer membranes have gained particular attention for the ability to tune opportunely their physicochemical properties under the application of an external stimulus. Heat, pH value, ionic strength, pressure, humidity, electric and magnetic fields, antigen/antibody interactions, chemical reactions, and light can be used as triggers for specific responses in polymer membranes. In particular, light is a fascinating stimulus, as it is a green energy, which can be modulated in a precise and convenient way. In addition, it allows remote and contactless interactions without changing the original chemical environment. This review reports recent progresses in light‐responsive polymer membranes with particular attention to chemical groups and responsive mechanisms.

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Light-responsive nanomedicine for biophotonic imaging and targeted therapy

Cited by 108 publications

References 96 publications

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Light‐Responsive Polymer Membranes

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