Light Prior to Eye Opening Promotes Retinal Waves and Eye-Specific Segregation

Tiriac, Alexandre; Smith, Ben; Feller, Marla B.

doi:10.1016/j.neuron.2018.10.011

Cited by 57 publications

(59 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…increases the frequency of those waves (Tiriac et al, 2018). Our model predicts that this would expedite the emergence of LHCs and that orientation-specific LHCs would be observed earlier than in a normal condition (Fig.…”

mentioning

confidence: 67%

Spontaneous Retinal Waves Can Generate Long-Range Horizontal Connectivity in Visual Cortex

et al. 2020

View full text Add to dashboard Cite

In the primary visual cortex (V1) of higher mammals, long-range horizontal connections (LHCs) are observed to develop, linking iso-orientation domains of cortical tuning. It is unknown how this feature-specific wiring of circuitry develops before eye-opening. Here, we suggest that LHCs in V1 may originate from spatiotemporally structured feedforward activities generated from spontaneous retinal waves. Using model simulations based on the anatomy and observed activity patterns of the retina, we show that waves propagating in retinal mosaics can initialize the wiring of LHCs by coactivating neurons of similar tuning, whereas equivalent random activities cannot induce such organizations. Simulations showed that emerged LHCs can produce the patterned activities observed in V1, matching the topography of the underlying orientation map. The model can also reproduce feature-specific microcircuits in the salt-and-pepper organizations found in rodents. Our results imply that early peripheral activities contribute significantly to cortical development of functional circuits.

show abstract

mentioning

confidence: 67%

Spontaneous Retinal Waves Can Generate Long-Range Horizontal Connectivity in Visual Cortex

et al. 2020

View full text Add to dashboard Cite

show abstract

“…photoreceptor dependent) (Fig. 3B), although a recent study reported light-dependent photoreceptor activity even prior to eye opening (P8-P10) (Tiriac et al, 2018). In contrast, light-responsive activity of intrinsically photosensitive melanopsin ganglion cells occurs from embryonic development (E16.5) into adulthood (Fig.…”

Section: The Relationship Between Neuronal and Glial Specification Anmentioning

confidence: 83%

Neuronal and glial regulation of CNS angiogenesis and barriergenesis

2020

View full text Add to dashboard Cite

Neurovascular pathologies of the central nervous system (CNS), which are associated with barrier dysfunction, are leading causes of death and disability. The roles that neuronal and glial progenitors and mature cells play in CNS angiogenesis and neurovascular barrier maturation have been elucidated in recent years. Yet how neuronal activity influences these processes remains largely unexplored. Here, we discuss our current understanding of how neuronal and glial development affects CNS angiogenesis and barriergenesis, and outline future directions to elucidate how neuronal activity might influence these processes. An understanding of these mechanisms is crucial for developing new interventions to treat neurovascular pathologies.

show abstract

“…Defective synaptic pruning of RGC inputs to the relay neurons in the dLGN leads to incomplete eye‐specific segregation (Schafer et al , ; Chung et al , ; Vainchtein et al , ). To investigate the effects of microglial GPR56 deficiency on eye‐specific segregation, we performed anterograde tracing of RGC inputs with two different colored fluorescent CTB (Fig A) and quantified the extent of segregation with a threshold‐independent method as described (Torborg & Feller, ; Tiriac et al , ). We observed a significantly larger overlap at P10 in CKO mice (Fig EV5A and B), persisting to P30 (Fig B–D) when eye‐specific segregation should be completed, suggesting improper organization of retinogeniculate projections sustained throughout development.…”

Section: Resultsmentioning

confidence: 99%

A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding

et al. 2020

View full text Add to dashboard Cite

Developmental synaptic remodeling is important for the formation of precise neural circuitry, and its disruption has been linked to neurodevelopmental disorders such as autism and schizophrenia. Microglia prune synapses, but integration of this synapse pruning with overlapping and concurrent neurodevelopmental processes, remains elusive. Adhesion G protein‐coupled receptor ADGRG1/GPR56 controls multiple aspects of brain development in a cell type‐specific manner: In neural progenitor cells, GPR56 regulates cortical lamination, whereas in oligodendrocyte progenitor cells, GPR56 controls developmental myelination and myelin repair. Here, we show that microglial GPR56 maintains appropriate synaptic numbers in several brain regions in a time‐ and circuit‐dependent fashion. Phosphatidylserine (PS) on presynaptic elements binds GPR56 in a domain‐specific manner, and microglia‐specific deletion of Gpr56 leads to increased synapses as a result of reduced microglial engulfment of PS+ presynaptic inputs. Remarkably, a particular alternatively spliced isoform of GPR56 is selectively required for microglia‐mediated synaptic pruning. Our present data provide a ligand‐ and isoform‐specific mechanism underlying microglial GPR56‐mediated synapse pruning in the context of complex neurodevelopmental processes.

show abstract

Light Prior to Eye Opening Promotes Retinal Waves and Eye-Specific Segregation

Cited by 57 publications

References 46 publications

Spontaneous Retinal Waves Can Generate Long-Range Horizontal Connectivity in Visual Cortex

Spontaneous Retinal Waves Can Generate Long-Range Horizontal Connectivity in Visual Cortex

Neuronal and glial regulation of CNS angiogenesis and barriergenesis

A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding

Contact Info

Product

Resources

About