Light-induced β-hydroxy sulfone synthesis in DNA-encoded libraries

Xue, Lijun; Yu, Jiaqing; Zhong, Ying; Chen, Junyun; Li, Chao; Yang, Kexin; Duchemin, Nicolas; Hu, Yun Jin

doi:10.1039/d4cc02193b

Chem. Commun.

2024

DOI: 10.1039/d4cc02193b

|View full text |Cite

Light-induced β-hydroxy sulfone synthesis in DNA-encoded libraries

Lijun Xue,

Jiaqing Yu,

Ying Zhong

et al.

Abstract: Visible-light photooxidation of sulfinate salts with common alkenes to yield β-hydroxy sulfones on DNA for DNA-encoded library synthesis.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 31 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Three-Component Reaction of Cyclopropanols, DABSO, and N-(Sulfonyl)acrylamides: Preparation of Sulfone-Bridged 1,7-Dicarbonyl Compounds

Chen,

Li,

Liu

et al. 2024

Org. Lett.

View full text Add to dashboard Cite

A cascade reaction of cyclopropyl alcohols, DABSO (1,4-diazoniabicyclo[2.2.2]octane-1,4-disulfinate), and N-(sulfonyl)acrylamides has been developed. This tandem process went through a cyclopropanol ring opening and Michael addition sequence. The γ-keto sulfinate generated from the reaction between cyclopropanol and DABSO serves as the nucleophilic reagent, and N-(sulfonyl)acrylamide is used as the Michael addition acceptor. By utilizing this strategy, multitudinous sulfonebridged 1,7-dicarbonyl compounds that contain both a β-sulfonyl amide unit and γ-keto sulfone skeleton were conveniently synthesized.

show abstract

Three-Component Reaction of Cyclopropanols, DABSO, and N-(Sulfonyl)acrylamides: Preparation of Sulfone-Bridged 1,7-Dicarbonyl Compounds

Chen,

Li,

Liu

et al. 2024

Org. Lett.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Light-induced β-hydroxy sulfone synthesis in DNA-encoded libraries

Abstract: Visible-light photooxidation of sulfinate salts with common alkenes to yield β-hydroxy sulfones on DNA for DNA-encoded library synthesis.

Cited by 1 publication

References 31 publications

Three-Component Reaction of Cyclopropanols, DABSO, and N-(Sulfonyl)acrylamides: Preparation of Sulfone-Bridged 1,7-Dicarbonyl Compounds

Three-Component Reaction of Cyclopropanols, DABSO, and N-(Sulfonyl)acrylamides: Preparation of Sulfone-Bridged 1,7-Dicarbonyl Compounds

Contact Info

Product

Resources

About