Light-induced release of DNA from plasmon-resonant nanoparticles: Towards light-controlled gene therapy

Barhoumi, Aoune; Huschka, Ryan; Bardhan, Rizia; Knight, Mark W.; Halas, Naomi J.

doi:10.1016/j.cplett.2009.09.076

Cited by 133 publications

(172 citation statements)

References 78 publications

(81 reference statements)

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“…Halas and coworkers used the nanoheatingrelease approach by using nanorods and nanoshells. 136,[148][149][150] In one particularly interesting example, they functionalized the nanoheaters with complementary nucleic acid strands, which upon light excitation can undergo dehybridization of the complementary strand, i.e., the therapeutic drug siRNA, inducing gene silencing. 136 Other approaches have been employed in organic microparticles (layer-by-layer capsules, 151 liposomes, 152 polymer particles, 75 etc.)…”

Section: Plasmonic Heatingmentioning

confidence: 99%

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Pino¹

2014

J. Biomed. Opt

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Abstract. Continuous advances in the field of bionanotechnology, particularly in the areas of synthesis and functionalization of colloidal inorganic nanoparticles with novel physicochemical properties, allow the development of innovative and/or enhanced approaches for medical solutions. Many of the present and future applications of bionanotechnology rely on the ability of nanoparticles to efficiently interact with electromagnetic (EM) fields and subsequently to produce a response via scattering or absorption of the interacting field. The crosssections of nanoparticles are typically orders of magnitude larger than organic molecules, which provide the means for manipulating EM fields and, thereby, enable applications in therapy (e.g., photothermal therapy, hyperthermia, drug release, etc.), sensing (e.g., surface plasmon resonance, surface-enhanced Raman, energy transfer, etc.), and imaging (e.g., magnetic resonance, optoacoustic, photothermal, etc.). Herein, an overview of the most relevant parameters and promising applications of EM-active nanoparticles for applications in life science are discussed with a view toward tailoring the interaction of nanoparticles with EM fields. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Plasmonic Heatingmentioning

confidence: 99%

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Pino¹

2014

J. Biomed. Opt

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“…Surface plasmon resonance on a metal nanoparticle or nanorod is a promising phenomenon that can provide increased local temperatures around the metal nanostructure. Light-induced dehybridization, or remotely controlled release of single-stranded DNA, has been demonstrated using gold nanoparticles and nanorods [16][17][18]. This method can be extended to the selective release of DNA strands using nanorods of various sizes, which are melted by ultrafast laser irradiation at different resonance wavelengths [19].…”

Section: Introductionmentioning

confidence: 99%

“…To date, optically controlled release has been studied for a variety of molecules, including insulin [11], anticancer drugs [12], angiogenesis inhibitors [13], and DNA [14][15][16]. Controlled release of a single-stranded DNA (ss-DNA) can be realized by dehybridization of a double-stranded DNA (dsDNA).…”

Section: Introductionmentioning

confidence: 99%

Optically controlled release of DNA based on nonradiative relaxation process of quenchers

Ogura

Onishi

Nishimura

et al. 2016

Biomed. Opt. Express

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Abstract:Optically controlled release of a DNA strand based on a nonradiative relaxation process of black hole quenchers (BHQs), which are a sort of dark quenchers, is presented. BHQs act as efficient energy sources because they relax completely via a nonradiative process, i.e., without fluorescent emission-based energy losses. A DNA strand is modified with BHQs and the release of its complementary strand is controlled by excitation of the BHQs. Experimental results showed that up to 50% of the target strands were released, and these strands were capable of inducing subsequent reactions. The controlled release was localized on a substrate within an area of no more than 5 micrometers in diameter.

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“…Barhoumi et al modified gold nanoshells with double-stranded DNA, and when the nanoshells were irradiated with near-IR light, the nanoshells were heated, and single-stranded DNA was released from the particles. 108 Gold nanorods can also be used as a photothermal transducer for DNA release.…”

Section: Controlled Release Systems Using Anisotropic Gold-based Nanomentioning

confidence: 99%

Anisotropic Gold-based Nanoparticles: Preparation, Properties, and Applications

2016

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Among the several types of nanoparticles in existence, anisotropic gold-based nanoparticles demonstrate special advantages because of their unique properties. Gold nanoparticles can be prepared and modified with a wide range of functional materials including polymers, surfactants, ligands, dendrimers, drugs, DNA, RNA, proteins, peptides, and oligonucleotides. Hence, they are a promising vehicle for bioimaging, drug delivery, and other therapies. This review mainly addresses the properties, preparation, and applications of anisotropic gold nanoparticles in biomedical applications and targeted drug delivery.

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Light-induced release of DNA from plasmon-resonant nanoparticles: Towards light-controlled gene therapy

Cited by 133 publications

References 78 publications

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Tailoring the interplay between electromagnetic fields and nanomaterials toward applications in life sciences: a review

Optically controlled release of DNA based on nonradiative relaxation process of quenchers

Anisotropic Gold-based Nanoparticles: Preparation, Properties, and Applications

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