Light induced cytosolic drug delivery from liposomes with gold nanoparticles

Lajunen, Tatu; Viitala, Lauri; Kontturi, Leena-Stiina; Laaksonen, Timo; Liang, Huamin; Vuorimaa‐Laukkanen, Elina; Viitala, Tapani; Guével, Xavier Le; Yliperttula, Marjo; Murtomäki, Lasse; Urtti, Arto

doi:10.1016/j.jconrel.2015.02.028

Cited by 120 publications

(91 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In all these cases, it is an attractive option to trigger drug release in the back of the eye at defined time and site using external light signal. Previous drug release experiments with light triggering 8, 10 and work running concurrently at the University of Helsinki 16 have confirmed that drugs can, indeed, be released from liposomes and delivered into human retina pigment epithelium cell line (ARPE- 19).…”

Section: Introductionmentioning

confidence: 90%

“…In physiological applications, this window is between 700 and 900 nm as these wavelengths penetrate human tissues deeper. This region can be achieved by using GNPs with shapes like nanorods 6 and nanostars 16 Films of adsorbed liposomes are complex systems also due to the fact that they are anisotropic. In addition to the bound liposome monolayer, these films vary in water sorption, packing density and surface interactions towards the film.…”

Section: Fluidity Change In Liposome Bilayer Due To Light Triggered Nmentioning

confidence: 99%

See 1 more Smart Citation

Detection of Phase Transition in Photosensitive Liposomes by Advanced QCM

et al. 2015

Self Cite

View full text Add to dashboard Cite

In this work an impedance-based quartz crystal microbalance (QCM) is used to detect heat induced changes in the viscoelastic properties in the films of adsorbed liposomes. Liposomes are bound to a polymer-modified QCM surface, and heat is induced in the bilayer via light absorption into gold nanoparticles (GNPs) embedded in the liposomes. Due to very rapid heat transfer at the nanoscale, nanoparticles can reside either in the liposome cavity or within the bilayer to cause changes in the lipid viscoelasticity. The changes are observed as changes in the film relaxation time as well as by mapping the measured resonance frequency vs. resistance. The QCM results indicate that viscoelastic changes occur throughout the vesicle layer, possibly causing fusion between the liposomes. The ultimate goal of the work is to develop a smart drug delivery system for the eye, whereby a drug loaded in the liposome can be released in a controlled manner by light triggering.

show abstract

Section: Introductionmentioning

confidence: 90%

Section: Fluidity Change In Liposome Bilayer Due To Light Triggered Nmentioning

confidence: 99%

Detection of Phase Transition in Photosensitive Liposomes by Advanced QCM

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…The results indicated good intracellular uptake and effective drug release in the cytosol after activation of the carrier by light. 149 …”

Section: Light Activation As a Component Of Dual/multiresponsive Smentioning

confidence: 99%

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

et al. 2017

View full text Add to dashboard Cite

Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, and so forth. Among drug delivery systems (DDSs), smart nanocarriers that respond to specific stimuli in their environment represent a growing field. Nanoplatforms that can be activated by an external application of light can be used for a wide variety of photoactivated therapies, especially light-triggered DDSs, relying on photoisomerization, photo-cross-linking/un-cross-linking, photoreduction, and so forth. In addition, light activation has potential in photodynamic therapy, photothermal therapy, radiotherapy, protected delivery of bioactive moieties, anticancer drug delivery systems, and theranostics (i.e., real-time monitoring and tracking combined with a therapeutic action to different diseases sites and organs). Combinations of these approaches can lead to enhanced and synergistic therapies, employing light as a trigger or for activation. Nonlinear light absorption mechanisms such as two-photon absorption and photon upconversion have been employed in the design of light-responsive DDSs. The integration of a light stimulus into dual/multiresponsive nanocarriers can provide spatiotemporal controlled delivery and release of therapeutic agents, targeted and controlled nanosystems, combined delivery of two or more agents, their on-demand release under specific conditions, and so forth. Overall, light-activated nanomedicines and DDSs are expected to provide more effective therapies against serious diseases such as cancers, inflammation, infections, and cardiovascular disease with reduced side effects and will open new doors toward the treatment of patients worldwide.

show abstract

“…Controlled release has been achieved in response to a change in intracellular environment such as pH 1 or by external stimulation such as light 2 or temperature. 3 Environment-responsive materials such as hydrogels, 4 polymers 5 or liposomes 6 are often used as carriers to deliver drugs.…”

Section: Introductionmentioning

confidence: 99%