Light-induced cleavage of DNA by metal complexes

Fleisher, M. B.; Waterman, Kenneth C.; Turro, Nicholas J.; Barton, Jacqueline K.

doi:10.1021/ic00240a001

Cited by 150 publications

(109 citation statements)

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“…On the basis of the viscosity results, it seems that these two complexes bind with DNA through groove binding. Although Barton and co-workers have proposed that [Co(phen) 3 ] þ 3 intercalated into double-stranded DNA [36], this viscosity experiment shows that [Co(phen) 3 ] þ 3 is not a DNA-intercalation agent. The order of increase in viscosity of complexes follows the order 4 > 3 > 2 > 1.…”

mentioning

confidence: 66%

DNA-Binding Studies of Mixed-Ligand (Ethylenediamine)ruthenium(II) Complexes

Nagababu

Latha

Satyanarayana

2006

C&B

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A series of mixed-ligand ruthenium(II) complexes of the type [Ru(en)(2)bpy](2+) (bpy=2,2-bipyridine; 1), [Ru(en)(2)phen](2+) (phen=1,10-phenantroline; 2), [Ru(en)(2)IP](2+) (IP=imidazo[4,5-f][1,10]phenanthroline; 3), and [Ru(en)(2)PIP](2+) (PIP=2-phenylimidazo[4,5-f][1,10]phenanthroline; 4) have been isolated and characterized by UV/VIS, IR, and (1)H-NMR spectral methods. The binding of the complexes with calf thymus DNA has been investigated by absorption, emission spectroscopy, viscosity measurements, DNA melting, and DNA photo-cleavage. The spectroscopic studies together with viscosity measurements and DNA melting studies support that complexes 1 and 2 bind to CT DNA (=calf thymus DNA) by groove mode. Complex 2 binds more avidly to CT DNA than complex 1, complexes 3 and 4 bind to CT DNA by intercalation mode, 4 binds more avidly to CT DNA than 3. Noticeably, the four complexes have been found to be efficient photosensitisers for strand scissions in plasmid DNA.

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mentioning

confidence: 66%

DNA-Binding Studies of Mixed-Ligand (Ethylenediamine)ruthenium(II) Complexes

Nagababu

Latha

Satyanarayana

2006

C&B

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“…The absence of faster migrating bands on the gel indicates the absence of frank breaks as it has been reported for other Ru II complexes. [6,40,65] Treatment of the oligonucleotide isolated from the gel after illumination, by piperidine or Fpg enzyme, did not induce the formation of faster migrating species. This strongly suggests that oxidised guanine moieties were not produced.…”

Section: Phen]mentioning

confidence: 90%

Photoreaction of [Ru(hat)₂phen]²⁺ with Guanosine‐5′‐Monophosphate and DNA: Formation of New Types of Photoadducts

Blasius

Nierengarten²,

Luhmer

et al. 2005

Chemistry A European J

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[Ru(hat)2phen]2+ (HAT=1,4,5,8,9,12-hexaazatriphenylene, phen=1,10-phenanthroline) interacts with a good affinity with polynucleotides and DNA by intercalation, despite the presence of a second voluminous ancillary HAT ligand. It photoreacts with guanosine-5'-monophosphate (GMP). From HPLC, ESMS and NMR analyses, it can be concluded that this complex forms photoadducts with GMP. In contrast to the photoadducts isolated with Ru-TAP complexes (TAP=1,4,5,8-tetraazaphenanthrene), the photoadducts with [Ru(hat)2phen]2+ contain a covalent link between the oxygen atom of the guanine unit and a HAT ligand. Formation of oxidised photoadducts and compounds resulting from the addition of two GMP entities to the complex are also detected as side products. In the presence of oligo- and polynucleotides, [Ru(hat)2phen]2+ yields photoadducts when guanine bases are present.

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“…The use of cobalt molecular complexes in the selective homogeneous photocatalytic cleavage of DNA has been known [21][22][23][24][25]. According to these studies, the low-spin Co 3+ complexes, in general, show several types of excited states that include ligand-field (LF), intraligand (IL) and charge-transfer (CT) states.…”

Section: Photocatalytic Investigationsmentioning

confidence: 99%

New photocatalysts based on mixed-metal pyridine dicarboxylates

2007

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New photocatalytically active isostructural two-dimensional mixed metal-pyridine dicarboxylates, [M(H 2 O) 3 Co{C 5 N 1 H 3 (COO) 2 } 3 ]) ¥ ], M = Gd (1), Dy (2) and Y (3) have been prepared under hydrothermal conditions. The structure consists of a network of MO 6 (H 2 O) 3 , CoO 3 N 3 polyhedral units connected by the pyridine dicarboxylates forming two-dimensional layers, which are arranged in an AAAA... fashion. The photocatalytic studies on 1 -3 indicate that they are active catalysts for the degradation of simple organic dyes, such as Remazol brilliant blue R (RBBR) and Orange G (OG) in the presence of UV light. The compounds have also been characterized by powder XRD, IR, TGA, UV-Vis and magnetic studies.

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Light-induced cleavage of DNA by metal complexes

Cited by 150 publications

References 0 publications

DNA-Binding Studies of Mixed-Ligand (Ethylenediamine)ruthenium(II) Complexes

DNA-Binding Studies of Mixed-Ligand (Ethylenediamine)ruthenium(II) Complexes

Photoreaction of [Ru(hat)₂phen]²⁺ with Guanosine‐5′‐Monophosphate and DNA: Formation of New Types of Photoadducts

New photocatalysts based on mixed-metal pyridine dicarboxylates

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Light-induced cleavage of DNA by metal complexes

Cited by 150 publications

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DNA-Binding Studies of Mixed-Ligand (Ethylenediamine)ruthenium(II) Complexes

DNA-Binding Studies of Mixed-Ligand (Ethylenediamine)ruthenium(II) Complexes

Photoreaction of [Ru(hat)2phen]2+ with Guanosine‐5′‐Monophosphate and DNA: Formation of New Types of Photoadducts

New photocatalysts based on mixed-metal pyridine dicarboxylates

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Photoreaction of [Ru(hat)₂phen]²⁺ with Guanosine‐5′‐Monophosphate and DNA: Formation of New Types of Photoadducts